Inhibition of human hair follicle growth by endoand exocannabinoids

FASEB Journal

Volumn 21, Issue 13, 2007, Pages 3534-3541

  Telek, Andrea ^a   Bíró, Tamás ^a   Bodó, Eniko ^b   Tóth, Balázs I ^a   Borbíró, István ^a   Kunos, George ^c   Paus, Ralf ^b  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Apoptosis; Cannabinoid receptor; Hair cycle; Proliferation

Indexed keywords

ANANDAMIDE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; DRONABINOL; ENDOCANNABINOID;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; HAIR FOLLICLE; HAIR GROWTH; HAIR LOSS; HUMAN; HUMAN CELL; KERATINOCYTE; ORGAN CULTURE; PRIORITY JOURNAL; REGULATORY MECHANISM; SCALP; SIGNAL TRANSDUCTION; TISSUE INTERACTION;

CANNABINOIDS; HAIR; HUMANS; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; RECEPTOR, CANNABINOID, CB1;

EID: 35948976128     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7689com     Document Type: Article

References (53)

1. Di Marzo, V., Bifulco, M., De Petrocellis, L. (2004) The endocannabinoid system and its therapeutic exploitation. Nat. Rev. Drug Discov. 3, 7712-7784
2. Piomelli, D. (2005) The endocannabinoid system: a drug discovery perspective. Curr. Opin. Investig. Drugs 6, 672-679
3. Pacher, P., Batkai, S., and Kunos, G. (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol. Rev. 58, 389-462
4. Di Marzo, V., and De Petrocellis, L. (2006) Plant, synthetic, and endogenous cannabinoids in medicine. Annu. Rev. Med. 57, 553-574
5. Felder, C. C., Dickason-Chesterfield, A. K., and Moore, S. A. (2006) Cannabinoids biology: the search for new therapeutic targets. Mol. Interv. 6, 149-161
6. De Vries, T. J., Shaham, Y., Homberg, J. R., Crombag, H., Schuurman, K., Dieben, J., Vanderschuren, L. J., and Schoffelmeer, A. N. (2001) A cannabinoid mechanism in relapse to cocaine seeking. Nat. Med. 7, 1151-1154
7. Freund, T. F., Katona, I., and Piomelli, D. (2003) Role of endogenous cannabinoids in synaptic signaling. Physiol. Rev. 83, 1017-1066
8. Jiang, W., Zhang, Y., Xiao, L., Van Cleemput, J., Ji, S. P., Bai, and G., Zhang, X. (2005) Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. J. Clin. Invest. 115, 3104-3416
9. Batkai, S., Jarai, Z., Wagner, J. A., Goparaju, S. K., Varga, K., Liu, J., Wang, L., Mirshahi, F., Khanolkar, A. D., Makriyannis, A., Urbaschek, R., Garcia, N. Jr., Sanyal, A. J., and Kunos, G. (2001) Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nat. Med. 7, 827-832
10. Croxford, J. L., Miller, S. D. (2003) Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212. J. Clin. Invest. 111, 1231-1240
11. Galve-Roperh, I., Sanchez, C., Cortes, M. L., del Pulgar, T. G., Izquierdo, M., Guzman, M. (2000) Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat. Med. 6, 313-319
12. Bifulco, M., Di Marzo, V. (2002) Targeting the endocannabinoid system in cancer therapy: a call for further research. Nat. Med. 8, 547-550
13. Blazquez, C., Casanova, M. L., Planas, A., Del Pulgar, T. G., Villanueva, C., Fernandez-Acenero, M. J., Aragones, J., Huffman, J. W., Jorcano, J. L., and Guzman, M. (2003) Inhibition of tumor angiogenesis by cannabinoids. FASEB J. 17, 529-531
14. Portella, G., Laezza, C., Laccetti, P., De Petrocellis, L., Di Marzo, V., and Bifulco, M. (2003) Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. FASEB J. 17, 1771-1773
15. Bifulco, M., Laezza, C., Valenti, M., Ligresti, A., Portella, G., and DiMarzo, V. (2004) A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. FASEB J. 18, 1606-1608
16. Blazquez, C., Carracedo, A., Barrado, L., Real, P. J., Fernandez-Luna, J. L., Velasco, G., Malumbres, M., and Guzman, M. (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J. 20, 2633-2635
17. Fernandez-Ruiz, J., Romero, J., Velasco, G., Tolon, R. M., Ramos, J. A., and Guzman, M. (2007) Cannabinoid CB(2) receptor: a new target for controlling neural cell survival? Trends. Pharmacol. Sci. 28, 39-45
18. Casanova, M. L., Blazquez, C., Martinez-Palacio, J., Villanueva, C., Fernandez-Acenero, M. J., Huffman, J. W., Jorcano, J. L., and Guzman, M. (2003) Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J. Clin. Invest. 111, 43-50
19. Maccarrone, M., Di Rienzo, M., Battista, N., Gasperi, V., Guerrieri, P., Rossi, A., and Finazzi-Agro, A. (2003) The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. J. Biol. Chem. 278, 33896-33903
20. Ständer, S., Schmelz, M., Metze, D., Luger, T. A., and Rukwied, R. (2005) Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J. Dermatol. Sci. 38, 177-188
21. Wilkinson, J. D., and Williamson, E. M. (2007) Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J. Dermatol. Sci. 45, 87-92
22. Philpott, M. P., Green, M. R., and Kealey, T. (1990) Human hair growth in vitro. J. Cell Sci. 3, 463-471
23. Bodó, E., Bíró, T., Telek, A., Czifra, G., Griger, Z., Tóth, I. B., Mescalchin, A., Ito, T., Bettermann, A., Kovács, L., and Paus, R. (2005) A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. Am. J. Pathol. 166, 985-998
24. Arck, P. C., Handjiski, B., Kuhlmei, A., Peters, E. M., Knackstedt, M., Peter, A., Hunt, S. P., Klapp, B. F., and Paus, R. (2005) Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition. J. Mol. Med. 83, 386-396
25. Peters, E. M., Arck, P. C., and Paus, R. (2006) Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control. Exp. Dermatol. 15, 1-13
26. Uhl, M., and Sachs, H. (2006) Cannabinoids in hair: strategy to prove marijuana/hashish consumption. Forensic. Sci. Int. 145, 143-147
27. Skopp, G., Strohbeck-Kuehner, P., Mann, K., and Hermann, D. (2006) Deposition of cannabinoids in hair after long-term use of cannabis. Forensic. Sci. Int. [Epub ahead of print]
28. Paus, R., Theoharides, T. C., and Arck, P. C. (2006) Neuroimmunoendocrine circuitry of the 'brain-skin connection'. Trends. Immunol. 27, 32-39
29. Botchkarev, V. A. (2003) Stress and the hair follicle: exploring the connections. Am. J. Pathol. 162, 709-712
30. Arck, P. C., Handjiski, B., Peters, E. M., Peter, A. S., Hagen, E., Fischer, A., Klapp, B. F., and Paus, R. (2003) Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. Am. J. Pathol. 162, 803-814
31. Ito, N., Ito, T., Kromminga, A., Bettermann, A., Takigawa, M., Kees, F., Straub, R. H., and Paus, R. (2005) Human hair follicles display a functional equivalent of the hypothalamic-pituitaryadrenal axis and synthesize cortisol. FASEB J. 19, 1332-1334
32. Foitzik, K., Krause, K., Conrad, F., Nakamura, M., Funk, W., and Paus, R. (2006) Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression. Am. J. Pathol. 168, 748-756
33. Paus, R., and Cotsarelis, G. (1999) The biology of hair follicles. N. Engl. J. Med. 341, 491-497
34. Stenn, K. D., and Paus, R. (2001) Controls of hair follicle cycling. Physiol. Rev. 81, 449-494
35. Slominski, A., and Wortsman, J. (2000) Neuroendocrinology of the skin. Endocr. Rev. 21, 457-487
36. Slominski, A., Wortsman, J., Luger, T., Paus, R., and Solomon, S. (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol. Rev. 80, 979-1020
37. Paus, R., Schmelz, M., Bíró, T., and Steinhoff, M. (2006) Frontiers in pruritus research: scratching the brain for more effective itch therapy. J. Clin. Invest. 116, 1174-1186
38. Arck, P. C., Slominski, A., Theoharides, T. C., Peters, E. M., and Paus, R. (2006) Neuroimmunology of stress: skin takes center stage. J. Invest. Dermatol. 126, 1697-1704
39. Slominski, A., Wortsman, J., Tuckey, R. C., and Paus, R. (2007) Differential expression of HPA axis homolog in the skin. Mol. Cell Endocrinol. 265, 143-149
40. Giuffrida, A., Rodriguez de Fonseca, F., and Piomelli, D. (2000) Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry. Anal. Biochem. 280, 87-93
41. Batkai, S., Osei-Hyiaman, D., Pan, H., El-Assal, O., Rajesh, M., Mukhopadhyay, P., Hong, F., Harvey-White, J., Jafri, A., Hasko, G., Huffman, J. W., Gao, B., Kunos, G., and Pacher. P. (2007) Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J. [Epub ahead of print]
42. Kogan, N. M., and Mechoulam, R. (2006) The chemistry of endocannabinoids. J. Endocrinol. Invest. 29, 3-14
43. Di Marzo, V., Blumberg, P. M., and Szallasi, A. (2002) Endovanilloid signaling in pain. Curr. Opin. Neurobiol. 12, 372-379
44. Van Der Stelt, M., and Di Marzo, V. (2004) Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur. J. Biochem. 271, 1827-1834
45. Pacher, P., Batkai, S., Osei-Hyiaman, D., Offertaler, L., Liu, J., Harvey-White, J., Brassai, A., Jarai, Z., Cravatt, B. F., and Kunos, G. (2005) Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. Am. J. Physiol. Heart. Circ. Physiol. 289, H533-541
46. Slominski, A., Paus, R., Plonka, P., Chakraborty, A., Maurer, M., Pruski, D., and Lukiewicz, S. (1994) Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle. J. Invest. Dermatol. 102, 862-869
47. Slominski, A., Tobin, D. J., Shibahara, S., and Wortsman, J. (2004) Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol. Rev. 84, 1155-1228
48. Slominski, A., Wortsman, J., Plonka, P. M., Schallreuter, K. U., Paus, R., and Tobin, D. J. (2005) Hair follicle pigmentation. J. Invest. Dermatol. 124, 13-21
49. Pacher, P., Batkai, S., and Kunos, G. (2004) Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. J. Physiol. 558, 647-657
50. Bíró, T., Bodó, E., Telek, A., Géczy, T., Tychsen, B., Kovács, L., and Paus, R. (2006) Hair cycle control by vanilloid receptor-1 (TRPV1): Evidence from TRPV1 knockout mice. J. Invest. Dermatol. 126, 1909-1912
51. Carrier, E. J., Patel, S., and Hillard, C. J. (2005) Endocannabinoids in neuroimmunology and stress. Curr. Drug. Targets CNS Neurol. Disord. 4, 657-665
52. Paus, R., Ito, N., Takigawa, M., and Ito, T. (2003) The hair follicle and immune privilege. J. Investig. Dermatol. Symp. Proc. 8, 188-194
53. Paus, R., Nickoloff, B. J., Ito, T. (2005) A 'hairy' privilege. Trends Immunol. 26, 32-40