메뉴 건너뛰기




Volumn 21, Issue 3, 2005, Pages 224-229

The role of caspase and calpain in neuronal apoptosis and pathogenesis of Huntington disease

Author keywords

Apoptosis; Calpain; Caspase; Huntingtin; Huntington disease; Neurodegenerative disorders

Indexed keywords

CALPAIN; CALPASTATIN; CASPASE; CYSTAMINE; LEUPEPTIN; MINOCYCLINE; PD 150606; PROTEASOME; PROTEIN BCL 2; UNCLASSIFIED DRUG;

EID: 35948942793     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (24)
  • 1
    • 0034641936 scopus 로고    scopus 로고
    • Yuan J, Yankner BA. Apoptosis in the nervous system. Nature, 2000, 407(6805):802-809.
    • Yuan J, Yankner BA. Apoptosis in the nervous system. Nature, 2000, 407(6805):802-809.
  • 2
    • 3343011970 scopus 로고    scopus 로고
    • Caspase activation, inhibition, and reactivation: A mechanistic view
    • Shi Y. Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci, 2004, 13(8):1979-1987.
    • (2004) Protein Sci , vol.13 , Issue.8 , pp. 1979-1987
    • Shi, Y.1
  • 3
    • 0036581270 scopus 로고    scopus 로고
    • Neural stem cell therapy for neurological diseases: Dreams and reality
    • Rossi F, Cattaneo E. Neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci, 2002, 3(5):401-409.
    • (2002) Nat Rev Neurosci , vol.3 , Issue.5 , pp. 401-409
    • Rossi, F.1    Cattaneo, E.2
  • 4
    • 0034739734 scopus 로고    scopus 로고
    • Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates
    • Yamashima T. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol, 2000, 62(3):273-295.
    • (2000) Prog Neurobiol , vol.62 , Issue.3 , pp. 273-295
    • Yamashima, T.1
  • 5
    • 0031465443 scopus 로고    scopus 로고
    • Conversion of Bcl-2 to a bax-like death effector by caspases
    • Cheng EHY, David G, Kirsch, et al. Conversion of Bcl-2 to a bax-like death effector by caspases. Science, 1997, 278(5345):1966-1968.
    • (1997) Science , vol.278 , Issue.5345 , pp. 1966-1968
    • Cheng, E.H.Y.1    David, G.2    Kirsch3
  • 6
    • 0035026438 scopus 로고    scopus 로고
    • Antiapoptotic proteins: The bcl-2 and inhibitor of apoptosis protein families
    • Deveraux QL, Schendel SL, Reed JC. Antiapoptotic proteins: the bcl-2 and inhibitor of apoptosis protein families. Cardiol Clin, 2001, 19(1):57-74.
    • (2001) Cardiol Clin , vol.19 , Issue.1 , pp. 57-74
    • Deveraux, Q.L.1    Schendel, S.L.2    Reed, J.C.3
  • 7
    • 0035127907 scopus 로고    scopus 로고
    • Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo
    • Leavitt BR, Guttman JA, Hodgson JG, et al. Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo. Am J Hum Genet, 2001, 68(2):313-324.
    • (2001) Am J Hum Genet , vol.68 , Issue.2 , pp. 313-324
    • Leavitt, B.R.1    Guttman, J.A.2    Hodgson, J.G.3
  • 8
    • 0035805504 scopus 로고    scopus 로고
    • Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing
    • Rigamonti D, Sipione S, Goffredo D, et al. Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing. J Biol Chem, 2001, 276(18):14545-14548.
    • (2001) J Biol Chem , vol.276 , Issue.18 , pp. 14545-14548
    • Rigamonti, D.1    Sipione, S.2    Goffredo, D.3
  • 9
    • 11144357398 scopus 로고    scopus 로고
    • Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease
    • Hermel E, Gafni J, Propp SS, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ, 2004, 11(4):424-438.
    • (2004) Cell Death Differ , vol.11 , Issue.4 , pp. 424-438
    • Hermel, E.1    Gafni, J.2    Propp, S.S.3
  • 10
    • 0037096376 scopus 로고    scopus 로고
    • Calpain activation in Huntington's disease
    • Gafni J, Ellerby LM. Calpain activation in Huntington's disease. J Neurosci, 2002, 22(12):4842-4849.
    • (2002) J Neurosci , vol.22 , Issue.12 , pp. 4842-4849
    • Gafni, J.1    Ellerby, L.M.2
  • 11
    • 2442631459 scopus 로고    scopus 로고
    • Inhibition of calpain cleavage of huntingtin reduces toxicity, accumulation of calpain/caspase fragments in the nucleus
    • Gafni JG, Hermel E, Young JE, et al. Inhibition of calpain cleavage of huntingtin reduces toxicity, accumulation of calpain/caspase fragments in the nucleus. J Biol Chem, 2004, 279(19):20211-20220.
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 20211-20220
    • Gafni, J.G.1    Hermel, E.2    Young, J.E.3
  • 12
    • 0037107151 scopus 로고    scopus 로고
    • Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
    • Wellington CL, Ellerby LM, Gutekunst CA, et al. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci, 2002, 22(18):7862-7872.
    • (2002) J Neurosci , vol.22 , Issue.18 , pp. 7862-7872
    • Wellington, C.L.1    Ellerby, L.M.2    Gutekunst, C.A.3
  • 13
    • 0344099572 scopus 로고    scopus 로고
    • Mechanisms of neuronal cell death in Huntington's disease
    • Sawa A, Tomoda T, Bae BI. Mechanisms of neuronal cell death in Huntington's disease. Cytogenet Genome Res, 2003, 100(1-4):287-295.
    • (2003) Cytogenet Genome Res , vol.100 , Issue.1-4 , pp. 287-295
    • Sawa, A.1    Tomoda, T.2    Bae, B.I.3
  • 14
    • 0141891215 scopus 로고    scopus 로고
    • Pathogenesis of polyglutamine disorders: Aggregation revisited
    • Article no. 90002
    • Michalik A, Van Broeckhoven C. Pathogenesis of polyglutamine disorders: aggregation revisited. Hum Mol Genet, 2003, 12(90002):R173-186.
    • (2003) Hum Mol Genet , vol.12
    • Michalik, A.1    Van Broeckhoven, C.2
  • 15
    • 0035940412 scopus 로고    scopus 로고
    • Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
    • Kim YJ, Yi Y, Sapp E, et al. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc Natl Acad Sci USA, 2001, 98(22):12784-12789.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.22 , pp. 12784-12789
    • Kim, Y.J.1    Yi, Y.2    Sapp, E.3
  • 16
    • 0036048873 scopus 로고    scopus 로고
    • Cytochrome C and caspase-9 expression in Huntington's disease
    • Kiechle T, Dedeoglu A, Kubilus J, et al. Cytochrome C and caspase-9 expression in Huntington's disease. Neuromolecular Med, 2002, 1(3):183-195.
    • (2002) Neuromolecular Med , vol.1 , Issue.3 , pp. 183-195
    • Kiechle, T.1    Dedeoglu, A.2    Kubilus, J.3
  • 17
    • 0141891952 scopus 로고    scopus 로고
    • Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity
    • Zhou H, Cao FL, Wang ZS, et al. Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity. J Cell Biol, 2003, 163(1):109-118.
    • (2003) J Cell Biol , vol.163 , Issue.1 , pp. 109-118
    • Zhou, H.1    Cao, F.L.2    Wang, Z.S.3
  • 18
    • 0348013126 scopus 로고    scopus 로고
    • Autophagy regulates processing of amino terminal htuntingtin fragments
    • Qin ZH, Wang Y, Kegel KB, et al. Autophagy regulates processing of amino terminal htuntingtin fragments. Hum Mol Genet, 2003, 12(24):3231-3244.
    • (2003) Hum Mol Genet , vol.12 , Issue.24 , pp. 3231-3244
    • Qin, Z.H.1    Wang, Y.2    Kegel, K.B.3
  • 19
    • 0842322740 scopus 로고    scopus 로고
    • Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction
    • Qin ZH, Wang Y, Sapp E, et al. Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. J Neurosci, 2004, 24(1):269-281.
    • (2004) J Neurosci , vol.24 , Issue.1 , pp. 269-281
    • Qin, Z.H.1    Wang, Y.2    Sapp, E.3
  • 20
    • 15944413899 scopus 로고    scopus 로고
    • The Paradigm of Huntington's disease: Therapeutic opportunities in neurodegeneration
    • Leegwater-Kim J, Cha JHJ. The Paradigm of Huntington's disease: therapeutic opportunities in neurodegeneration. NeuroRx, 2004, 1(1):128-138.
    • (2004) NeuroRx , vol.1 , Issue.1 , pp. 128-138
    • Leegwater-Kim, J.1    Cha, J.H.J.2
  • 21
    • 0347285445 scopus 로고    scopus 로고
    • Why minocycline is helpful in Huntington's disease
    • Bonelli RM, Kapfhammer HP. Why minocycline is helpful in Huntington's disease. J Psychopharmacol, 2003, 17(4):461.
    • (2003) J Psychopharmacol , vol.17 , Issue.4 , pp. 461
    • Bonelli, R.M.1    Kapfhammer, H.P.2
  • 22
    • 0036172346 scopus 로고    scopus 로고
    • Prolonged survival and decreased abnormal movements in transgenic model of Huntington's disease, with administration of the transglutaminase inhibitor cystamine
    • Karpuj MV, Becher MW, Springer JE, et al. Prolonged survival and decreased abnormal movements in transgenic model of Huntington's disease, with administration of the transglutaminase inhibitor cystamine. Nat Med, 2002, 8(2):143-149.
    • (2002) Nat Med , vol.8 , Issue.2 , pp. 143-149
    • Karpuj, M.V.1    Becher, M.W.2    Springer, J.E.3
  • 23
    • 0037423204 scopus 로고    scopus 로고
    • Cystamine inhibits caspase activity: Implications for the treatment of polyglutamine disorders
    • Lesort M, Lee M, Tucholski J, et al. Cystamine inhibits caspase activity: Implications for the treatment of polyglutamine disorders. J Biol Chem, 2003, 278(6):3825-3830.
    • (2003) J Biol Chem , vol.278 , Issue.6 , pp. 3825-3830
    • Lesort, M.1    Lee, M.2    Tucholski, J.3
  • 24
    • 1842504064 scopus 로고    scopus 로고
    • Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration
    • Kieran D, GreensmithL. Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration. Neuroscience, 2004, 125(2):427-439.
    • (2004) Neuroscience , vol.125 , Issue.2 , pp. 427-439
    • Kieran, D.1    GreensmithL2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.