Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration

Neuroscience

Volumn 125, Issue 2, 2004, Pages 427-439

  Kieran, D ^a   Greensmith, L ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

amino 3 hydroxy 5 methyl 4 isoxazole propionic acid; ABC; AMPA; Apoptosis; Avidin biotin complex; Bovine serum albumin; BSA; Calpains; Days in vitro; DIV; EDL; Extensor digitorum longus muscle; Fatigue index; FI; Motor unit; MTT; Nerve injury

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CALPAIN; CALPASTATIN; LEUPEPTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LUMBAR SPINAL CORD; MOTONEURON; MOTOR UNIT; MUSCLE FUNCTION; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SOLEUS MUSCLE;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANIMALS, NEWBORN; CALPAIN; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID AGENTS; FEMALE; IMMUNOHISTOCHEMISTRY; ISOMETRIC CONTRACTION; LEUPEPTINS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MOTOR NEURON DISEASE; MOTOR NEURONS; MUSCLE FATIGUE; MUSCLE FIBERS; MUSCLE, SKELETAL; MYOSINS; NERVE CRUSH; NERVE DEGENERATION; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NEUROPATHY; SPINAL CORD; STAINING AND LABELING; TIME FACTORS;

EID: 1842504064     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2004.01.046     Document Type: Article

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