Apolactoferrin inhibits the catalytic domain of matrix metalloproteinase-2 by zinc chelation

Biochemistry and Cell Biology

Volumn 85, Issue 5, 2007, Pages 563-572

  Newsome, Anthony L ^a   Johnson, Jon Paul ^a   Seipelt, Rebecca L ^a   Thompson, Michael W ^a  

^a Middle Tennesee State University   (United States)

Author keywords

Gelatinase; Iron; Lactoferrin; Matrix metalloproteinase; Metalloprotease; MMP 2; Zinc

Indexed keywords

APOLACTOFERRIN; GELATINASE; MATRIX METALLOPROTEINASES (MMP); METALLOPROTEINASE;

BINDING SITES; CHELATION; HYDROLYSIS; PROTEINS; PROTEOLYSIS; ZINC COMPOUNDS;

CATALYST ACTIVITY;

APOLACTOFERRIN; COLLAGENASE 3; FERROUS CHLORIDE; GELATINASE A; GELATINASE B; HOLOLACTOFERRIN; INTERSTITIAL COLLAGENASE; IRON; LACTOFERRIN; NEUTROPHIL COLLAGENASE; UNCLASSIFIED DRUG; ZINC; ZINC CHLORIDE;

ARTICLE; CHELATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROLYSIS; IN VIVO STUDY; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; TEMPERATURE;

APOPROTEINS; CATALYTIC DOMAIN; CHELATING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LACTOFERRIN; MATRIX METALLOPROTEINASE 2; TEMPERATURE; ZINC;

EID: 35948932575     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/O07-073     Document Type: Article

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