Immunolocalization of lactoferrin in healthy and inflamed gingival tissues

Journal of Periodontology

Volumn 77, Issue 3, 2006, Pages 472-478

  Eberhard, Jörg ^a   Drosos, Zacharias ^a   Tiemann, Markus ^a   Jepsen, Søren ^b   Schröder, Jens M ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Epithelium; Immune system; Keratinocytes; Lactoferrin

Indexed keywords

LACTOFERRIN; MESSENGER RNA;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL INFILTRATION; CLINICAL ARTICLE; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GINGIVAL BIOPSY; GINGIVITIS; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; IN VITRO STUDY; INFLAMMATION; INNATE IMMUNITY; KERATINOCYTE; MALE; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CHEMISTRY; GINGIVA; METABOLISM; MIDDLE AGED; NEUTROPHIL;

ADULT; AGED; CELLS, CULTURED; FEMALE; GINGIVA; GINGIVAL CREVICULAR FLUID; GINGIVITIS; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; LACTOFERRIN; MALE; MIDDLE AGED; NEUTROPHILS;

EID: 33646349487     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2006.050186     Document Type: Article

References (45)

1. Mandel ID. The functions of saliva. J Dent Res 1987; 66:623-627.
2. Tenovuo J, Lumikari M, Soukka T. Salivary lysozyme, lactoferrin and peroxidases: Antibacterial effects on cariogenic bacteria and clinical applications in preventive dentistry. Proc Finn Dent Soc 1991;87:197-208.
3. Narhi TO, Tenovuo J, Ainamo A, Vilja P. Antimicrobial factors, sialic acid, and protein concentration in whole saliva of the elderly. Scand J Dent Res 1994;102: 120-125.
4. Aisen P, Listowsky I. Iron transport and storage proteins. Annu Rev Biochem 1980;49:357-393.
5. Masson PL, Heremans JF. Lactoferrin in milk from different species. Comp Biochem Physiol B 1971;39: 119-129.
6. Levay PF, Viljoen M. Lactoferrin: A general review. Haematologica 1995;80:252-267.
7. Friedman SA, Mandel ID, Herrera MS. Lysozyme and lactoferrin quantitation in the crevicular fluid. J Periodontol 1983;54:347-350.
8. Masson PL, Heremans JF, Schonne E. Lactoferrin, an iron-binding protein in neutrophilic leukocytes. J Exp Med 1969;130:643-658.
9. Sugi K, Saitoh O, Hirata I, Fecal Katsu K. Lactoferrin as a marker for disease activity in inflammatory bowel disease: Comparison with other neutrophil-derived proteins. Am J Gastroenterol 1996;91:927-934.
10. Thompson AB, Bohling T, Payvandi F, Rennard SI. Lower respiratory tract lactoferrin and lysozyme arise primarily in the airways and are elevated in association with chronic bronchitis. J Lab Clin Med 1990; 115:148-158.
11. Arnold RR, Brewer M, Gauthier JJ. Bactericidal activity of human lactoferrin: Sensitivity of a variety of microorganisms. Infect Immun 1980;28:893-898.
12. Arnold RR, Cole MF, McGhee JR. A bactericidal effect for human lactoferrin. Science 1977;197:263-265.
13. Nemet K, Simonovits I. The biological role of lactoferrin. Haematologia (Budap) 1985;18:3-12.
14. Singh PK, Parsek MR, Greenberg EP, Welsh MJ. A component of innate immunity prevents bacterial biofilm development. Nature 2002;417:552-555.
15. Meyer-Hoffert U, Wichmann N, Schwichtenberg L, White PC, Wiedow O. Supernatants of Pseudomonas aeruginosa induce the Pseudomonas-specific antibiotic elafin in human keratinocytes. Exp Dermatol 2003; 12:418-425.
16. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988;106:761-771.
17. Schroder JM. Epithelial antimicrobial peptides: Innate local host response elements. Cell Mol Life Sci 1999; 56:32-46.
18. Kagnoff MF, Eckmann L. Epithelial cells as sensors for microbial infection. J Clin Invest 1997;100:6-10.
19. Eberhard J, Jepsen S, Pohl L, Albers HK, Acil Y. Bacterial challenge stimulates formation of arachidonic acid metabolites by human keratinocytes and neutrophils in vitro. Clin Diagn Lab Immunol 2002;9: 132-137.
20. Adonogianaki E, Moughal NA, Kinane DF. Lactoferrin in the gingival crevice as a marker of polymorphonuclear leucocytes in periodontal diseases. J Clin Periodontol 1993;20:26-31.
21. Gustafsson A, Asman B, Bergstrom K. Elastase and lactoferrin in gingival crevicular fluid: Possible indicators of a granulocyte-associated specific host response. J Periodontal Res 1994;29:276-282.
22. Miyasaki KT, Voganatsi A, Huynh T, Marcus M, Underwood S. Calprotectin and lactoferrin levels in the gingival crevicular fluid of children. J Periodontol 1998;69:879-883.
23. Mason DY, Taylor CR. Distribution of transferrin, ferritin, and lactoferrin in human tissues. J Clin Pathol 1978;31:316-327.
24. Gillette TE, Allansmith MR. Lactoferrin in human ocular tissues. Am J Ophthalmol 1980;90:30-37.
25. Tedeschi A, Tuccari G, Magazzu G, Arena F, Ricciardi R, Barresi G. Immunohistochemical localization of lactoferrin in duodenojejunal mucosa from celiac children. J Pediatr Gastroenterol Nutr 1987;6:328-334.
26. Ghio AJ, Carter JD, Samet JM, et al. Metal-dependent expression of ferritin and lactoferrin by respiratory epithelial cells. Am J Physiol 1998;274:L728-L736.
27. Nibbering PH, Ravensbergen E, Welling MM, et al. Human lactoferrin and peptides derived from its n terminus are highly effective against infections with antibiotic-resistant bacteria. Infect Immun 2001;69: 1469-1476.
28. Pollanen MT, Hakkinen L, Overman DO, Salonen JI. Lactoferrin impedes epithelial cell adhesion in vitro. J Periodontal Res 1998;33:8-16.
29. Ellison RT 3rd. The effects of lactoferrin on gram-negative bacteria. Adv Exp Med Biol 1994;357:71-90.
30. Longhi C, Conte MP, Seganti L, Polidoro M, Alfsen A, Valenti P. Influence of lactoferrin on the entry process of Escherichia coli HB101 (pri203) into HeLa cells. Med Microbiol Immunol (Berl) 1993;182:25-35.
31. Kawasaki Y, Tazume S, Shimizu K, et al. Inhibitory effects of bovine lactoferrin on the adherence of enterotoxigenic Escherichia coli to host cells. Biosci Biotechnol Biochem 2000;64:348-354.
32. De Araujo AN, Giugliano LG. Lactoferrin and free secretory component of human milk inhibit the adhesion of enteropathogenic Escherichia coli to HeLa cells. BMC Microbiol 2001;1:25. Epub 2001 Oct 9.
33. Gomez HF, Ochoa TJ, Herrera-Insua I, Carlin LG, Cleary TG. Lactoferrin protects rabbits from Shigella flexneri-induced inflammatory enteritis. Infect Immun 2002;70:7050-7053.
34. Fine DH, Furgang D. Lactoferrin iron levels affect attachment of Actinobacillus actinomycetemcomitans to buccal epithelial cells. J Periodontol 2002;73:616-623.
35. Alugupalli KR, Kalfas S. Degradation of lactoferrin by periodontitis-associated bacteria. FEMS Microbiol Lett 1996;145:209-214.
36. Oho T, Mitoma M, Koga T. Functional domain of bovine milk lactoferrin which inhibits the adherence of Streptococcus mutans cells to a salivary film. Infect Immun 2002;70:5279-5282.
37. De Lillo A, Teanpaisan R, Fierro JF, Douglas CW. Binding and degradation of lactoferrin by Porphyromonas gingivalis, Prevotella intermedia and Prevotella nigrescens. FEMS Immunol Med Microbiol 1996;14: 135-143.
38. Grenier D, Goulet V, Mayrand D. The capacity of Porphyromonas gingivalis to multiply under iron-limiting conditions correlates with its pathogenicity in an animal model. J Dent Res 2001;80:1678-1682.
39. Aguila A, Herrera AG, Morrison D, et al. Bacteriostatic activity of human lactoferrin against Staphylococcus aureus is a function of its iron-binding properties and is not influenced by antibiotic resistance. FEMS Immunol Med Microbiol 2001;31:145-152.
40. Dwarakanath AD, Finnie IA, Beesley CM, et al. Differential excretion of leucocyte granule components in inflammatory bowel disease: Implications for pathogenesis. Clin Sci (Lond) 1997;92:307-313.
41. Murray MC, Mooney J, Kinane DF. The relationship between elastase and lactoferrin in healthy, gingivitis and periodontitis sites. Oral Dis 1995;1:106-109.
42. Tsai CC, Kao CC, Chen CC. Gingival crevicular fluid lactoferrin levels in adult periodontitis patients. Aust Dent J 1998;43:40-44.
43. Rudney JD, Krig MA, Neuvar EK, Soberay AH, Iverson L. Antimicrobial proteins in human unstimulated whole saliva in relation to each other, and to measures of health status, dental plaque accumulation and composition. Arch Oral Biol 1991;36:497-506.
44. Martinez-Gomis J, Fernandez-Solanas A, Vinas M, Gonzalez P, Planas ME, Sanchez S. Effects of topical application of free and liposome-encapsulated lactoferrin and lactoperoxidase on oral microbiota and dental caries in rats. Arch Oral Biol 1999;44:901-906.
45. Groenink J, Walgreen-Weterings E, Nazmi K, et al. Salivary lactoferrin and low-Mr mucin MG2 in Actinobacillus actinomycetemcomitans-associated periodontitis. J Clin Periodontol 1999;26:269-275.