CD8+ T cells in inflammatory demyelinating disease

Journal of Neuroimmunology

Volumn 191, Issue 1-2, 2007, Pages 79-85

  Weiss, Hanne A ^a   Millward, Jason M ^a,b   Owens, Trevor ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

CD8; EAE; Interferon gamma; Interleukin 17; MS; T cells

Indexed keywords

CYTOKINE; GAMMA INTERFERON ANTIBODY; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ALLERGIC ENCEPHALOMYELITIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE COURSE; DRUG EFFICACY; DRUG WITHDRAWAL; HUMAN; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; INTERLEUKIN-17; MULTIPLE SCLEROSIS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 35848945932     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2007.09.011     Document Type: Review

References (42)

1. Arnason B.G. Immunologic therapy of multiple sclerosis. Annu. Rev. Med. 50 (1999) 291-302
2. Babbe H., Roers A., Waisman A., Lassmann H., Goebels N., Hohlfeld R., Friese M., Schroder R., Deckert M., Schmidt S., Ravid R., and Rajewsky K. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 192 (2000) 393-404
3. Becher B., Durell B.G., and Noelle R.J. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110 (2002) 493-497
4. + T cells in a spontaneous model of demyelinating disease. J. Immunol. 177 (2006) 2403-2411
5. Chen Y., Langrish C.L., McKenzie B., Joyce-Shaikh B., Stumhofer J.S., McClanahan T., Blumenschein W., Churakovsa T., Low J., Presta L., Hunter C.A., Kastelein R.A., and Cua D.J. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J. Clin. Invest. 116 (2006) 1317-1326
6. Compston A., and Coles A. Multiple sclerosis. Lancet 359 (2002) 1221-1231
7. Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M., Lira S.A., Gorman D., Kastelein R.A., and Sedgwick J.D. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003) 744-748
8. Feldmann M., and Maini R.N. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?. Annu. Rev. Immunol. 19 (2001) 163-196
9. Feldmann M., and Steinman L. Design of effective immunotherapy for human autoimmunity. Nature 435 (2005) 612-619
10. Ferber I.A., Brocke S., Taylor-Edwards C., Ridgway W., Dinisco C., Steinman L., Dalton D., and Fathman C.G. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156 (1996) 5-7
11. Ford M.L., and Evavold B.D. Specificity, magnitude, and kinetics of MOG-specific CD8(+) T cell responses during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 35 (2005) 76-85
12. Friese M.A., and Fugger L. Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?. Brain 128 (2005) 1747-1763
13. Gold R., Linington C., and Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129 (2006) 1953-1971
14. Hu D., Ikizawa K., Lu L., Sanchirico M.E., Shinohara M.L., and Cantor H. Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat. Immunol. 5 (2004) 516-523
15. Huseby E.S., Liggitt D., Brabb T., Schnabel B., Ohlen C., and Goverman J. A pathogenic role for myelin-specific cd8(+) t cells in a model for multiple sclerosis. J. Exp. Med. 194 (2001) 669-676
16. Ji Q., and Goverman J. Experimental autoimmune encephalomyelitis mediated by CD8+ T Cells. Ann. N.Y. Acad. Sci. 1103 (2007) 157-166
17. Jiang H., Zhang S.I., and Pernis B. Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science 256 (1992) 1213-1215
18. Kelso A., and Gough N.M. Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 9189-9193
19. Koh D.R., Fung-Leung W.P., Ho A., Gray D., Acha-Orbea H., and Mak T.W. Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science 256 (1992) 1210-1213
20. Komiyama Y., Nakae S., Matsuki T., Nambu A., Ishigame H., Kakuta S., Sudo K., and Iwakura Y. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177 (2006) 566-573
21. Krakowski M., and Owens T. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 26 (1996) 1641-1646
22. Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., McClanahan T., Kastelein R.A., and Cua D.J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201 (2005) 233-240
23. Linker R.A., Rott E., Hofstetter H.H., Hanke T., Toyka K.V., and Gold R. EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responses. Neurobiol. Dis. 19 (2005) 218-228
24. McKenzie B.S., Kastelein R.A., and Cua D.J. Understanding the IL-23-IL-17 immune pathway. Trends Immunol. 27 (2006) 17-23
25. Najafian N., Chitnis T., Salama A.D., Zhu B., Benou C., Yuan X., Clarkson M.R., Sayegh M.H., and Khoury S.J. Regulatory functions of CD8+ CD28- T cells in an autoimmune disease model. J. Clin. Invest. 112 (2003) 1037-1048
26. Owens T., Wekerle H., and Antel J. Genetic models for CNS inflammation. Nat. Med. 7 (2001) 161-166
27. Panitch H.S., Hirsch R.L., Haley A.S., and Johnson K.P. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1 (1987) 893-895
28. Popko B., Corbin J.G., Baerwald K.D., Dupree J., and Garcia A.M. The effects of interferon-gamma on the central nervous system. Mol. Neurobiol. 14 (1997) 19-35
29. Samoilova E.B., Horton J.L., Hilliard B., Liu T.S., and Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161 (1998) 6480-6486
30. Skurkovich S., Boiko A., Beliaeva I., Buglak A., Alekseeva T., Smirnova N., Kulakova O., Tchechonin V., Gurova O., Deomina T., Favorova O.O., Skurkovic B., and Gusev E. Randomized study of antibodies to IFN-gamma and TNF-alpha in secondary progressive multiple sclerosis. Mult. Scler. 7 (2001) 277-284
31. Steinman L. Myelin-specific cd8 t cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis. J. Exp. Med. 194 (2001) F27-F30
32. Steinman L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat. Med. 13 (2007) 139-145
33. Sun D., Whitaker J.N., Huang Z., Liu D., Coleclough C., Wekerle H., and Raine C.S. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J. Immunol. 166 (2001) 7579-7587
34. Suryani S., and Sutton I. An interferon-gamma-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis. J. Neuroimmunol. 183 (2007) 96-103
35. Sutton C., Brereton C., Keogh B., Mills K.H., and Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203 (2006) 1685-1691
36. TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology 53 (1999) 457-465
37. van Oosten B.W., Barkhof F., Truyen L., Boringa J.B., Bertelsmann F.W., von Blomberg B.M., Woody J.N., Hartung H.P., and Polman C.H. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2. Neurology 47 (1996) 1531-1534
38. Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
39. Wheeler R.D., Zehntner S.P., Kelly L.M., Bourbonniere L., and Owens T. Elevated interferon gamma expression in the central nervous system of tumour necrosis factor receptor 1-deficient mice with experimental autoimmune encephalomyelitis. Immunology 118 (2006) 527-538
40. Willenborg D.O., Fordham S., Bernard C.C., Cowden W.B., and Ramshaw I.A. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157 (1996) 3223-3227
41. Zeine R., and Owens T. Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RB(low) CD4+ T cells that induce experimental allergic encephalomyelitis. J. Neuroimmunol. 40 (1992) 57-69
42. Zeine R., and Owens T. Loss rather than downregulation of CD4+ T cells as a mechanism for remission from experimental allergic encephalomyelitis. J. Neuroimmunol. 44 (1993) 193-198