Epithelial mesenchymal transition during the neoplastic transformation of human breast epithelial cells by estrogen

International Journal of Oncology

Volumn 31, Issue 4, 2007, Pages 823-827

  Tiezzi, Daniel G ^a   Fernandez, Sandra V ^a   Russo, Jose ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Breast cancer; Epithelial mesenchymal transition; Estrogen

Indexed keywords

COLLAGEN; ESTRADIOL; MESSENGER RNA; TUMOR PROTEIN;

ARTICLE; BREAST TUMOR; CANCER INVASION; CELL ADHESION; CELL TRANSFORMATION; DRUG EFFECT; ENZYME IMMUNOASSAY; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MESODERM; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BREAST NEOPLASMS; CELL ADHESION; CELL TRANSFORMATION, NEOPLASTIC; COLLAGEN; EPITHELIUM; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; MESODERM; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 35848937146     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.31.4.823     Document Type: Article

References (27)

1. Yang J, Mani SA, Donaher JL, et al: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117: 927-939, 2004. (Pubitemid 38798858)
2. Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
3. Nelson CM, Vanduijn MM, Inman JL, Fletcher DA and Bissell MJ: Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science 314: 298-300, 2006.
4. Kang Y and Massague J: Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118: 277-279, 2004. (Pubitemid 39061108)
5. Lee JM, Dedhar S, Kalluri R and Thompson EW: The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172: 973-981, 2006.
6. Wheelock MJ and Johnson KR: Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol 19: 207-235, 2003.
7. Hay ED: An overview of epithelio-mesenchymal transformation. Acta Anat 154: 8-20, 1995.
8. Debnath J and Brugge JS: Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 5: 675-688, 2005. (Pubitemid 41486361)
9. Grunert S, Jechlinger M and Beug H: Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 4: 657-665, 2003. (Pubitemid 36934968)
10. Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, Beug H and Grunert S: Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol 156: 299-313, 2002. (Pubitemid 34839911)
11. Russo J, Fernandez SV, Russo PA, Fernbaugh R, Sheriff FS, Lareef HM, Garber J and Russo IH: 17-Beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells. FASEB J 20: 1622-1634, 2006. (Pubitemid 44943799)
12. Schock F and Perrimon N: Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol 18: 463-493, 2002.
13. Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006.
14. Oft M, Peli J, Rudaz C, Schwarz H, Beug H and Reichmann E: TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10: 2462-2477, 1996. (Pubitemid 26341881)
15. Miettinen PJ, Ebner R, Lopez AR and Derynck R: TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 127: 2021-2036, 1994.
16. Massague J and Wotton D: Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19: 1745-1754, 2000. (Pubitemid 30204386)
17. Itoh S, Itoh F, Goumans MJ and ten Dijke P: Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 267: 6954-6967, 2000.
18. Flanders KC: Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 85: 47-64, 2004.
19. Zavadil J, Cermak L, Soto-Nieves N and Bottinger EP: Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J 23: 1155-1165, 2004.
20. Korchynskyi O, Landstrom M, Stoika R, Funa K, Heldin CH, ten Dijke P and Souchelnytskyi S: Expression of Smad proteins in human colorectal cancer. Int J Cancer 82: 197-202, 1999.
21. Van Beijnum JR, Moerkerk PT, Gerbers AJ, De Bruine AP, Arends JW, Hoogenboom HR and Hufton SE: Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer. Int J Cancer 101: 118-127, 2002.
22. Kwok WK, Ling MT, Lee TW, et al: Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res 65: 5153-5162, 2005.
23. Lee TK, Poon RT, Yuen AP, et al: Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 12: 5369-5376, 2006.
24. Leptin M: Twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev 5: 1568-1576, 1991.
25. Nieto MA: The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3: 155-166, 2002.
26. Blanco MJ, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, Palacios J and Nieto MA: Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 21: 3241-3246, 2002.
27. Huang J, Hardy JD, Sun Y and Shively JE: Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J Cell Sci 112: 4193-4205, 1999.