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Volumn 6, Issue 5, 1997, Pages 483-488

Hyperhomocysteinemia: Detection, risk assessment, and treatment

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID;

EID: 0030929483     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199709000-00013     Document Type: Review
Times cited : (27)

References (48)
  • 2
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J Am Med Assoc 1995, 274:1049-1057.
    • (1995) J Am Med Assoc , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 3
    • 0029911977 scopus 로고    scopus 로고
    • Homocysteinemia and vascular disease in end-stage renal disease
    • Dennis VW, Robinson K: Homocysteinemia and vascular disease in end-stage renal disease. Kidney Int 1997, 50(suppl):S11-S17.
    • (1997) Kidney Int , vol.50 , Issue.SUPPL.
    • Dennis, V.W.1    Robinson, K.2
  • 4
    • 0030058721 scopus 로고    scopus 로고
    • Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia
    • Kang SS, Wong PW: Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia. Atherosclerosis 1996, 119:135-138. Hyperhomocysteinemia can be classified as moderate, intermediate or severe, on the basis of the basal homocysteine level. A single genetic defect without a second one or a nongenetic factor (e.g. folic acid deficiency) might not be sufficient to produce overt hyperhomocysteinemia. A genetic defect might be essential for persistent hyperhomocysteinemia.
    • (1996) Atherosclerosis , vol.119 , pp. 135-138
    • Kang, S.S.1    Wong, P.W.2
  • 5
    • 0029939676 scopus 로고    scopus 로고
    • Homocysteine and vascular disease
    • McCully KS: Homocysteine and vascular disease. Nature Med 1996, 2:386-389.
    • (1996) Nature Med , vol.2 , pp. 386-389
    • McCully, K.S.1
  • 6
    • 0029029934 scopus 로고
    • Plasma homocyst(e)ine or homocysteine?
    • Mudd SH, Levy HL: Plasma homocyst(e)ine or homocysteine? [Letter]. N Engl J Med 1995, 333:325.
    • (1995) N Engl J Med , vol.333 , pp. 325
    • Mudd, S.H.1    Levy, H.L.2
  • 11
    • 10544252271 scopus 로고    scopus 로고
    • Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations
    • Robinson K, Gupta A, Dennis VW, Arheart K, Chaudhary D, Green R, Vigo P, Mayer EL, Selhub J, Kutner M, Jacobsen D: Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations. Circulation 1996, 94:2743-2748. This is an extensive and comprehensive analysis of the problem of hyperhomocysteinemia in ESRD patients.
    • (1996) Circulation , vol.94 , pp. 2743-2748
    • Robinson, K.1    Gupta, A.2    Dennis, V.W.3    Arheart, K.4    Chaudhary, D.5    Green, R.6    Vigo, P.7    Mayer, E.L.8    Selhub, J.9    Kutner, M.10    Jacobsen, D.11
  • 14
    • 0029847109 scopus 로고    scopus 로고
    • Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR
    • Goyette P, Christensen B, Rosenblatt DS, Rozen R: Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR. Am J Hum Genet 1996, 59:1268-1275.
    • (1996) Am J Hum Genet , vol.59 , pp. 1268-1275
    • Goyette, P.1    Christensen, B.2    Rosenblatt, D.S.3    Rozen, R.4
  • 15
    • 0029948013 scopus 로고    scopus 로고
    • Homocysteine response to methionine challenge in four obligate heterozygotes for homocystinuria and relationship with cystathionine beta-synthase mutations
    • Sperandeo MP, Candito M, Sebastio G, Rolland MO, Turc-Carel C, Giudicelli H, Dellamonica P, Andria G: Homocysteine response to methionine challenge in four obligate heterozygotes for homocystinuria and relationship with cystathionine beta-synthase mutations. J Inherit Metab Dis 1996, 19:351-356.
    • (1996) J Inherit Metab Dis , vol.19 , pp. 351-356
    • Sperandeo, M.P.1    Candito, M.2    Sebastio, G.3    Rolland, M.O.4    Turc-Carel, C.5    Giudicelli, H.6    Dellamonica, P.7    Andria, G.8
  • 16
    • 0023696435 scopus 로고
    • Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
    • Kang SS, Zhou J, Wong PW, Kowalisyn J, Strokosch G: Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 1988, 43:414-421.
    • (1988) Am J Hum Genet , vol.43 , pp. 414-421
    • Kang, S.S.1    Zhou, J.2    Wong, P.W.3    Kowalisyn, J.4    Strokosch, G.5
  • 17
    • 0026034240 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase: An inherited risk factor for coronary artery disease
    • Kang SS, Wong PWK, Susmano A, Sora J, Norusis M, Ruggie N: Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease. Am J Hum Genet 1991, 48:536-545.
    • (1991) Am J Hum Genet , vol.48 , pp. 536-545
    • Kang, S.S.1    Wong, P.W.K.2    Susmano, A.3    Sora, J.4    Norusis, M.5    Ruggie, N.6
  • 18
    • 0027421353 scopus 로고
    • Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease
    • Kang SS, Passen EL, Ruggie N, Wong PW, Sora H: Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1993, 88:1463-1469.
    • (1993) Circulation , vol.88 , pp. 1463-1469
    • Kang, S.S.1    Passen, E.L.2    Ruggie, N.3    Wong, P.W.4    Sora, H.5
  • 20
    • 0026034240 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase: An inherited risk factor for coronary artery disease
    • Kang SS, Wong PW, Susmano A, Sora J, Norusis M, Ruggie N: Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease. Am J Hum Genet 1991, 48:536-545.
    • (1991) Am J Hum Genet , vol.48 , pp. 536-545
    • Kang, S.S.1    Wong, P.W.2    Susmano, A.3    Sora, J.4    Norusis, M.5    Ruggie, N.6
  • 21
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R: Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996, 93:7-9. The strong association between hyperhomocysteinemia, low folate and homozygosity for thermolabile MTHFR indicate that the mutated enzyme might not be under normal regulation.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3    Ellison, R.C.4    Eckfeldt, J.H.5    Rosenberg, I.H.6    Selhub, J.7    Rozen, R.8
  • 23
    • 0029974036 scopus 로고    scopus 로고
    • Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study
    • Guttormsen AB, Ueland PM, Nesthus I, Nygard O, Schneede J, Vollset SE, Refsum H: Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study. J Clin Invest 1996, 98:2174-2183. Based on the Hordaland Homocysteine Study, the authors identified a group with intermediate homocysteine levels who responded to a low dose of folic acid with substantial reduction and even normalization of their elevated homocysteine levels.
    • (1996) J Clin Invest , vol.98 , pp. 2174-2183
    • Guttormsen, A.B.1    Ueland, P.M.2    Nesthus, I.3    Nygard, O.4    Schneede, J.5    Vollset, S.E.6    Refsum, H.7
  • 24
    • 0029968008 scopus 로고    scopus 로고
    • Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study
    • Schmitz C, Lindpaintner K, Verhoef P, Gaziano JM, Buring J: Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study. Circulation 1996, 94:1812-1814.
    • (1996) Circulation , vol.94 , pp. 1812-1814
    • Schmitz, C.1    Lindpaintner, K.2    Verhoef, P.3    Gaziano, J.M.4    Buring, J.5
  • 25
    • 0029806746 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, plasma tolate, homocysteine, and risk of myocardial infarction in US physicians
    • Ma J, Stampfer MJ, Hennekens CH, Frosst P, Selhub J, Horsford J, Malinow MR, Willett WC, Rozen R: Methylenetetrahydrofolate reductase polymorphism, plasma tolate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 1996, 94:2410-2416. The highlight of this study was the lack of increased risk for myocardial infarction associated with MTHFR polymorphism, in spite of higher homocysteine levels.
    • (1996) Circulation , vol.94 , pp. 2410-2416
    • Ma, J.1    Stampfer, M.J.2    Hennekens, C.H.3    Frosst, P.4    Selhub, J.5    Horsford, J.6    Malinow, M.R.7    Willett, W.C.8    Rozen, R.9
  • 28
    • 0030934392 scopus 로고    scopus 로고
    • Correlation ot a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease
    • Christensen B, Frosst P, Lussier-Cacan S, Selhub J, Goyette P, Rosenblatt DS, Genest J, Rozen R: Correlation ot a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler Thromb Vasc Biol 1997, 17:569-573.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 569-573
    • Christensen, B.1    Frosst, P.2    Lussier-Cacan, S.3    Selhub, J.4    Goyette, P.5    Rosenblatt, D.S.6    Genest, J.7    Rozen, R.8
  • 31
    • 0029938389 scopus 로고    scopus 로고
    • Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine
    • Matthias D, Becker CH, Riezler R, Kindling PH: Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine. Atherosclerosis 1996, 122:201-216. The direct angiotoxic effects of homocysteine are again demonstrated. The more pronounced effects observed in spontaneous hypertensive rats suggest an interrelation between cardiovascular risk factors.
    • (1996) Atherosclerosis , vol.122 , pp. 201-216
    • Matthias, D.1    Becker, C.H.2    Riezler, R.3    Kindling, P.H.4
  • 32
    • 0030015522 scopus 로고    scopus 로고
    • Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia
    • Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, Heistad DD: Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest 1996, 98:24-29 This study provides in-vivo data that hyperhomocystinemia alters endothelial and vascular function without morphologic changes. In addition to altered vasoactive responsiveness, thrombomodulin anticoagulant activity was decreased.
    • (1996) J Clin Invest , vol.98 , pp. 24-29
    • Lentz, S.R.1    Sobey, C.G.2    Piegors, D.J.3    Bhopatkar, M.Y.4    Faraci, F.M.5    Malinow, M.R.6    Heistad, D.D.7
  • 33
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans
    • Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA: Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 1997, 95:1119-1121.
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 34
    • 0029866820 scopus 로고    scopus 로고
    • Homocysteine, EDRF, and endothelial function
    • Upchurch GR Jr, Welch GN, Loscalzo J: Homocysteine, EDRF, and endothelial function. J Nutr 1996, 126(suppl):1290S-1294S.
    • (1996) J Nutr , vol.126 , Issue.SUPPL.
    • Upchurch Jr., G.R.1    Welch, G.N.2    Loscalzo, J.3
  • 35
    • 0030188563 scopus 로고    scopus 로고
    • The oxidant stress of hyperhomocyst(e)inemia
    • Loscalzo J: The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest 1996, 98:5-7.
    • (1996) J Clin Invest , vol.98 , pp. 5-7
    • Loscalzo, J.1
  • 36
    • 0342624737 scopus 로고    scopus 로고
    • Homocysteine mediated endothelial cell toxicity and its amelioration
    • Blundell G, Jones BG, Rose FA, Tudball N: Homocysteine mediated endothelial cell toxicity and its amelioration. Atherosclerosis 1996, 122:163-172.
    • (1996) Atherosclerosis , vol.122 , pp. 163-172
    • Blundell, G.1    Jones, B.G.2    Rose, F.A.3    Tudball, N.4
  • 37
    • 0029860742 scopus 로고    scopus 로고
    • Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes
    • Kokame K, Kato H, Miyata T: Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J Biol Chem 1996, 271:29659-29665. This study shows direct effects of homocysteine on endothelial cells and their gene regulation. It extends the range of mechanisms by which homocysteine might disturb cellular metabolism.
    • (1996) J Biol Chem , vol.271 , pp. 29659-29665
    • Kokame, K.1    Kato, H.2    Miyata, T.3
  • 41
    • 0029869178 scopus 로고    scopus 로고
    • Increased cyclin dependent kinase in aortic tissue of rats fed homocysteine
    • Lubec B, Arbeiter K, Hoeger H, Lubec G: Increased cyclin dependent kinase in aortic tissue of rats fed homocysteine. Thromb Haemost 1996, 75:542-545.
    • (1996) Thromb Haemost , vol.75 , pp. 542-545
    • Lubec, B.1    Arbeiter, K.2    Hoeger, H.3    Lubec, G.4
  • 43
    • 0030022202 scopus 로고    scopus 로고
    • The effect of reduced glomerular filtration rate on plasma total homocysteine concentration
    • Arnadottir M, Hultberg B, Nilsson-Ehle P, Thysell H: The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Lab Invest 1996, 56:41-46.
    • (1996) Scand J Clin Lab Invest , vol.56 , pp. 41-46
    • Arnadottir, M.1    Hultberg, B.2    Nilsson-Ehle, P.3    Thysell, H.4
  • 44
    • 0027163587 scopus 로고
    • Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading
    • Guttormsen AB, Mansoor AM, Fiskerstrand T, Ueland PM, Refsum H: Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading. Clin Chem 1993, 39:1390-1397.
    • (1993) Clin Chem , vol.39 , pp. 1390-1397
    • Guttormsen, A.B.1    Mansoor, A.M.2    Fiskerstrand, T.3    Ueland, P.M.4    Refsum, H.5
  • 45
    • 0023949170 scopus 로고
    • Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: Possible implications for prevention of vascular disease
    • Wilcken DEL, Dudman NPB, Tyrrell PA, Robertson MR: Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease. Metabolism 1988, 37:697-701.
    • (1988) Metabolism , vol.37 , pp. 697-701
    • Wilcken, D.E.L.1    Dudman, N.P.B.2    Tyrrell, P.A.3    Robertson, M.R.4
  • 47
    • 0029655771 scopus 로고    scopus 로고
    • Long-term folic acid (but not pyridoxine) supplementation lowers elevated plasma homocysteine level in chronic renal failure
    • Chauveau P, Chadefaux B, Coude M, Aupetit J, Kamoun P, Jungers P: Long-term folic acid (but not pyridoxine) supplementation lowers elevated plasma homocysteine level in chronic renal failure. Miner Electrolyte Metab 1996, 22:106-109.
    • (1996) Miner Electrolyte Metab , vol.22 , pp. 106-109
    • Chauveau, P.1    Chadefaux, B.2    Coude, M.3    Aupetit, J.4    Kamoun, P.5    Jungers, P.6


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