HbS-Savaria: The anti-polymerization effect of a single mutation in human α-chains

Protein Journal

Volumn 26, Issue 8, 2007, Pages 523-532

  Srinivasulu, Sonati ^a   Acharya, A Seetharama ^a   Prabhakaran, Muthuchidambaran ^a   Fabry, Mary E ^a   Alami, Raouf ^a   Fiering, Steven N ^b   Bouhasirra, Eric E ^a   Nagel, Ronald L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

Gene therapy; Hemoglobin S; Hemoglobin Savaria; Polymerization inhibition; Sickle cell anemia

Indexed keywords

BETA GLOBIN; HEMOGLOBIN S; RECOMBINANT HEMOGLOBIN S SAVARIA; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PEPTIDE MAPPING; POLYMERIZATION; SICKLE CELL ANEMIA;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; HEME; HEMOGLOBINS, ABNORMAL; HUMANS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, MOLECULAR; MUTATION; OOCYTES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 35848930778     PISSN: 15723887     EISSN: 15734943     Source Type: Journal    
DOI: 10.1007/s10930-007-9089-9     Document Type: Article

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