Roles of α114 and β87 amino acid residues in the polymerization of hemoglobin S: Implications for gene therapy

Journal of Molecular Biology

Volumn 263, Issue 3, 1996, Pages 475-485

  Ho, Chien ^a   Willis, Barbara F ^a,d   Shen, Tong Jian ^a   Ho, Nancy T ^a   Sun, Dazhen Philip ^a   Tam, Ming F ^b   Suzuka, Sandra M ^c   Fabry, Mary E ^c   Nagel, Ronald L ^c  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Gene therapy; Inhibition of Hb S polymerization; Intermolecular contact sites in Hb S polymer; Recombinant mutants of Hb S

Indexed keywords

ALPHA AMINO ACID; BETA AMINO ACID; HEMOGLOBIN S; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE MUTATION; GENE THERAPY; HUMAN; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; SICKLE CELL ANEMIA;

ESCHERICHIA COLI;

EID: 0030298199     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0590     Document Type: Article

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