Interspecies hybrid HbS: Complete neutralization of Val6(β)-dependent polymerization of human β-chain by pig α-chains

Journal of Molecular Biology

Volumn 300, Issue 5, 2000, Pages 1389-1406

  Rao, M Janardhan ^a   Malavalli, Ashok ^a   Manjula, Belur N ^c   Kumar, Ramesh ^b   Prabhakaran, Muthuchidambaran ^e   Sun, D Philip ^d   Ho, Nancy T ^d   Ho, Chien ^d   Nagel, Ronald L ^a,c   Acharya, A Seetharama ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b DNX Corporation   (United States)

^c Department of Physiology and Biophysics ^*  (United States)

^d CARNEGIE MELLON UNIVERSITY   (United States)

^e Structural Bioinformatics Inc   (United States)

Author keywords

Antisickling globins; Gene therapy; Hybrid Hb; Molecular modeling; Semisynthetic chimeric chains

Indexed keywords

HEMOGLOBIN S; HYBRID PROTEIN;

ALPHA CHAIN; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BETA CHAIN; ELECTRICITY; HUMAN; HUMAN CELL; NONHUMAN; OXYGEN AFFINITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN POLYMERIZATION; PROTEIN PURIFICATION; SPECIES DIFFERENCE; SWINE;

EID: 0034725526     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3898     Document Type: Article

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