Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: Assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms

European Journal of Pharmaceutical Sciences

Volumn 32, Issue 4-5, 2007, Pages 261-270

  Lind, Marianne L ^a   Jacobsen, Jette ^a   Holm, René ^b   Müllertz, Anette ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

Caco 2 cell culture; Intestinal absorption; Simulated intestinal fluid; Transport medium

Indexed keywords

CARBON DIOXIDE; ESTRADIOL; ETOPOSIDE; GLYCEROL OLEATE; LACTATE DEHYDROGENASE; LYSOPHOSPHATIDYLCHOLINE; OLEIC ACID; PHOSPHATIDYLCHOLINE; TAUROCHOLIC ACID;

ARTICLE; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL STRAIN CACO 2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PENETRATION; DRUG TRANSPORT; ELECTRIC RESISTANCE; ENZYME RELEASE; HUMAN; HUMAN CELL; INTESTINE FLUID; LIPOLYSIS; NUTRITION; PRIORITY JOURNAL; PROTEIN CONTENT;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA; DRUG STABILITY; ESTRADIOL; ETOPOSIDE; FOOD; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL SECRETIONS; L-LACTATE DEHYDROGENASE; LYSOPHOSPHATIDYLCHOLINES; MEMBRANE PROTEINS; MICELLES; OSMOLAR CONCENTRATION; PERMEABILITY; PHOSPHATIDYLCHOLINES; SOLUBILITY; SURFACE-ACTIVE AGENTS; TAUROCHOLIC ACID; WATER;

EID: 35748980571     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.08.002     Document Type: Article

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