-
1
-
-
0036148405
-
Development of bisphosphonates
-
Fleisch H. Development of bisphosphonates. Breast Cancer Res 2002; 4: 30-34.
-
(2002)
Breast Cancer Res
, vol.4
, pp. 30-34
-
-
Fleisch, H.1
-
2
-
-
0032942599
-
Bisphosphonates: Pharmacology, mechanisms of action and clinical uses
-
Russell RG, Croucher PI, Rogers MJ. Bisphosphonates: Pharmacology, mechanisms of action and clinical uses. Osteoporosis Int 1999; 9 (Suppl 2): S66-S80.
-
(1999)
Osteoporosis Int
, vol.9
, Issue.SUPPL. 2
-
-
Russell, R.G.1
Croucher, P.I.2
Rogers, M.J.3
-
3
-
-
0032996153
-
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: Biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
-
Benford HL, Frith JC, Auriola S et al. Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: Biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. Mol Pharmacol 1999; 56: 131-140.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 131-140
-
-
Benford, H.L.1
Frith, J.C.2
Auriola, S.3
-
4
-
-
0031754521
-
Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: Evidence from structure-activity relationships in J774 macrophages
-
Luckman SP, Coxon FP, Ebetino FH et al. Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: Evidence from structure-activity relationships in J774 macrophages. J Bone Miner Res 1998; 13: 1668-1678.
-
(1998)
J Bone Miner Res
, vol.13
, pp. 1668-1678
-
-
Luckman, S.P.1
Coxon, F.P.2
Ebetino, F.H.3
-
5
-
-
0031977199
-
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
-
Luckman SP, Hughes DE, Coxon FP et al. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 1998; 13: 581-589.
-
(1998)
J Bone Miner Res
, vol.13
, pp. 581-589
-
-
Luckman, S.P.1
Hughes, D.E.2
Coxon, F.P.3
-
6
-
-
0032859149
-
The pharmacology of bisphosphonates and new insights into their mechanisms of action
-
Russell RG, Rogers MJ, Frith JC et al. The pharmacology of bisphosphonates and new insights into their mechanisms of action. J Bone Miner Res 1999; 14 (Suppl 2): 53-65.
-
(1999)
J Bone Miner Res
, vol.14
, Issue.SUPPL. 2
, pp. 53-65
-
-
Russell, R.G.1
Rogers, M.J.2
Frith, J.C.3
-
7
-
-
0033620684
-
Farnesyltransferase inhibitors: Targeting the molecular basis of cancer
-
Oliff A. Farnesyltransferase inhibitors: Targeting the molecular basis of cancer. Biochim Biophys Acta 1999; 1423: C19-C30.
-
(1999)
Biochim Biophys Acta
, vol.1423
-
-
Oliff, A.1
-
8
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang FL, Casey PJ. Protein prenylation: Molecular mechanisms and functional consequences. Annu Rev Biochem 1996; 65: 241-269.
-
(1996)
Annu Rev Biochem
, vol.65
, pp. 241-269
-
-
Zhang, F.L.1
Casey, P.J.2
-
9
-
-
0036238837
-
Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite
-
Lehenkari PP, Kellinsalmi M, Napankangas JP et al. Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol 2002; 61: 1255-1262.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 1255-1262
-
-
Lehenkari, P.P.1
Kellinsalmi, M.2
Napankangas, J.P.3
-
10
-
-
0029829704
-
Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages
-
Selander KS, Monkkonen J, Karhukorpi EK et al. Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol 1996; 50: 1127-1138.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 1127-1138
-
-
Selander, K.S.1
Monkkonen, J.2
Karhukorpi, E.K.3
-
11
-
-
33845299812
-
Zoledronic acid in the management of metastatic bone disease
-
Santini D, Fratto ME, Vincenzi B et al. Zoledronic acid in the management of metastatic bone disease. Expert Opin Biol Ther 2006; 6: 1333-1348.
-
(2006)
Expert Opin Biol Ther
, vol.6
, pp. 1333-1348
-
-
Santini, D.1
Fratto, M.E.2
Vincenzi, B.3
-
12
-
-
33845529993
-
Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signalling pathways
-
Hasmin M, Bieler G, Ruegg G. Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signalling pathways. J Thromb Haemost 2007; 5: 166-173.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 166-173
-
-
Hasmin, M.1
Bieler, G.2
Ruegg, G.3
-
13
-
-
0035360867
-
The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases
-
Hiraga T, Williams PJ, Mundy GR, Yoneda T. The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases. Cancer Res 2001; 61: 4418-4424.
-
(2001)
Cancer Res
, vol.61
, pp. 4418-4424
-
-
Hiraga, T.1
Williams, P.J.2
Mundy, G.R.3
Yoneda, T.4
-
14
-
-
0034107048
-
Bisphosphonates induce apoptosis in human breast cancer cell lines
-
Senaratne SG, Pirianov G, Mansi JL et al. Bisphosphonates induce apoptosis in human breast cancer cell lines. Br J Cancer 2000; 82: 1459-1468.
-
(2000)
Br J Cancer
, vol.82
, pp. 1459-1468
-
-
Senaratne, S.G.1
Pirianov, G.2
Mansi, J.L.3
-
15
-
-
0030931858
-
Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity
-
Shipman CM, Rogers MJ, Apperley JF et al. Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity, Br J Haematol 1997; 98: 665-672.
-
(1997)
Br J Haematol
, vol.98
, pp. 665-672
-
-
Shipman, C.M.1
Rogers, M.J.2
Apperley, J.F.3
-
16
-
-
0032404144
-
The bisphosphonate incadronate [YM175] causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway
-
Shipman CM, Croucher PI, Russell RG et al. The bisphosphonate incadronate [YM175] causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Res 1998; 58: 5294-5297.
-
(1998)
Cancer Res
, vol.58
, pp. 5294-5297
-
-
Shipman, C.M.1
Croucher, P.I.2
Russell, R.G.3
-
17
-
-
0035179684
-
A newly developed bisphosphonate, YM529, is a potent apoptosis inducer of human myeloma cells
-
Takahashi R, Shimazaki C, Inaba T et al. A newly developed bisphosphonate, YM529, is a potent apoptosis inducer of human myeloma cells. Leuk Res 2001; 25: 77-83.
-
(2001)
Leuk Res
, vol.25
, pp. 77-83
-
-
Takahashi, R.1
Shimazaki, C.2
Inaba, T.3
-
18
-
-
0038235983
-
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro
-
Tassone P, Tagliaferri P, Viscomi C et al. Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br J Cancer 2003; 88: 1971-1978.
-
(2003)
Br J Cancer
, vol.88
, pp. 1971-1978
-
-
Tassone, P.1
Tagliaferri, P.2
Viscomi, C.3
-
19
-
-
0035051719
-
Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro
-
Benford HL, McGowan NWA, Helfrich MH et al. Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro. Bone 2001; 28: 465-473.
-
(2001)
Bone
, vol.28
, pp. 465-473
-
-
Benford, H.L.1
McGowan, N.W.A.2
Helfrich, M.H.3
-
20
-
-
0033783227
-
Bisphosphonates induce breast cancer cell death in vitro
-
Fromigue O, Lagneaux L, Body JJ. Bisphosphonates induce breast cancer cell death in vitro. J Bone Miner Res 2000; 15: 2211-2221.
-
(2000)
J Bone Miner Res
, vol.15
, pp. 2211-2221
-
-
Fromigue, O.1
Lagneaux, L.2
Body, J.J.3
-
21
-
-
0037277846
-
The antitumor potential of bisphosphonates
-
Clezardin P. The antitumor potential of bisphosphonates. Semin Oncol 2002; 29: 33-42.
-
(2002)
Semin Oncol
, vol.29
, pp. 33-42
-
-
Clezardin, P.1
-
22
-
-
0242308942
-
Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: Evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival
-
Croucher PI, De Hendrik R, Perry MJ et al. Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival. J Bone Miner Res 2003; 18: 482-492.
-
(2003)
J Bone Miner Res
, vol.18
, pp. 482-492
-
-
Croucher, P.I.1
De Hendrik, R.2
Perry, M.J.3
-
23
-
-
0034660687
-
Stimulation of gamma/delta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma
-
Kunzmann V, Bauer E, Feurle J et al. Stimulation of gamma/delta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 2000; 96: 384-392.
-
(2000)
Blood
, vol.96
, pp. 384-392
-
-
Kunzmann, V.1
Bauer, E.2
Feurle, J.3
-
24
-
-
0141567513
-
Induction of gamma/delta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo
-
Dieli F, Gebbia N, Poccia F et al. Induction of gamma/delta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo. Blood 2003; 102: 2310-2311.
-
(2003)
Blood
, vol.102
, pp. 2310-2311
-
-
Dieli, F.1
Gebbia, N.2
Poccia, F.3
-
25
-
-
0037029682
-
-
Senaratne SG, Mansi JL, Colston KW. The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells. Br J Cancer 2002; 86: 1479-1486erratum in Br J Cancer 2002; 87: 1340.
-
Senaratne SG, Mansi JL, Colston KW. The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells. Br J Cancer 2002; 86: 1479-1486erratum in Br J Cancer 2002; 87: 1340.
-
-
-
-
26
-
-
0034214362
-
Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
-
Boissier S, Ferreras M, Peyruchaud O et al. Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res 2000; 60: 2949-2954.
-
(2000)
Cancer Res
, vol.60
, pp. 2949-2954
-
-
Boissier, S.1
Ferreras, M.2
Peyruchaud, O.3
-
27
-
-
0030826872
-
Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices
-
Boissier S, Magnetto S, Frappart L et al. Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices. Cancer Res 1997; 57: 3890-3894.
-
(1997)
Cancer Res
, vol.57
, pp. 3890-3894
-
-
Boissier, S.1
Magnetto, S.2
Frappart, L.3
-
28
-
-
0032881209
-
Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone
-
Magnetto S, Boissier S, Delmas PD, Clezardin P. Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone. Int J Cancer 1999 83: 263-269.
-
(1999)
Int J Cancer
, vol.83
, pp. 263-269
-
-
Magnetto, S.1
Boissier, S.2
Delmas, P.D.3
Clezardin, P.4
-
29
-
-
0029916052
-
Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro
-
van der Pluijm G, Vloedgraven H, van Beek E et al. Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro. J Clin Invest 1996; 98: 698-705.
-
(1996)
J Clin Invest
, vol.98
, pp. 698-705
-
-
van der Pluijm, G.1
Vloedgraven, H.2
van Beek, E.3
-
30
-
-
0242353251
-
Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: Evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt
-
Bezzi M, Hasmim M, Bieler G et al. Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: Evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt. J Biol Chem 2003; 278: 43603-43614.
-
(2003)
J Biol Chem
, vol.278
, pp. 43603-43614
-
-
Bezzi, M.1
Hasmim, M.2
Bieler, G.3
-
31
-
-
0036093899
-
Pamidronate induces modifications of circulating angiogenetic factors in cancer patients
-
Santini D, Vincenzi B, Avvisati G et al. Pamidronate induces modifications of circulating angiogenetic factors in cancer patients. Clin Cancer Res 2002; 8: 1080-1084.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1080-1084
-
-
Santini, D.1
Vincenzi, B.2
Avvisati, G.3
-
32
-
-
10744227993
-
Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients
-
Santini D, Vincenzi B, Dicuonzo G et al. Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients. Clin Cancer Res 2003; 9: 2893-2897.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2893-2897
-
-
Santini, D.1
Vincenzi, B.2
Dicuonzo, G.3
-
33
-
-
20144381765
-
Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients
-
Vincenzi B, Santini D, Dicuonzo G et al. Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients. J Interferon Cytokine Res 2005; 25: 144-1451.
-
(2005)
J Interferon Cytokine Res
, vol.25
, pp. 144-1451
-
-
Vincenzi, B.1
Santini, D.2
Dicuonzo, G.3
-
34
-
-
33746337357
-
Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival
-
Gouin F, Gory B, Redini F, Heymann D. Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival. Int J Cancer 2006; 119: 980-984.
-
(2006)
Int J Cancer
, vol.119
, pp. 980-984
-
-
Gouin, F.1
Gory, B.2
Redini, F.3
Heymann, D.4
-
35
-
-
0036181668
-
Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
-
Yaccoby S, Pearse RN, Johnson CL et al. Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol 2002; 116: 278-290.
-
(2002)
Br J Haematol
, vol.116
, pp. 278-290
-
-
Yaccoby, S.1
Pearse, R.N.2
Johnson, C.L.3
-
36
-
-
3042729728
-
Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model
-
Hiraga T, Williams PJ, Ueda A et al. Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clin Cancer Res 2004; 10: 4559-4567.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4559-4567
-
-
Hiraga, T.1
Williams, P.J.2
Ueda, A.3
-
37
-
-
24044553904
-
Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro
-
Woodward JK, Neville-Webbe HL, Coleman RE, Holen I. Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro. Anticancer Drugs 2005; 16: 845-854.
-
(2005)
Anticancer Drugs
, vol.16
, pp. 845-854
-
-
Woodward, J.K.1
Neville-Webbe, H.L.2
Coleman, R.E.3
Holen, I.4
-
38
-
-
12844285156
-
Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines
-
Algur E, Macklis RM, Hafeli UO. Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines, Int J Radiat Oncol Biol Phys 2005; 61: 535-542.
-
(2005)
Int J Radiat Oncol Biol Phys
, vol.61
, pp. 535-542
-
-
Algur, E.1
Macklis, R.M.2
Hafeli, U.O.3
-
39
-
-
21344462168
-
Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor r115777 in human epithelial cancer cells
-
Caraglia M, Giuberti G, Marra M et al. Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor r115777 in human epithelial cancer cells. Front Biosci 2005; 10: 2566-2575.
-
(2005)
Front Biosci
, vol.10
, pp. 2566-2575
-
-
Caraglia, M.1
Giuberti, G.2
Marra, M.3
-
40
-
-
0842278680
-
Antiproliferative efficacy of the third-generation bisphosphonate, zoledronic acid, combined with other anticancer drugs in leukemic cell lines
-
Kimura S, Kuroda J, Segawa H et al. Antiproliferative efficacy of the third-generation bisphosphonate, zoledronic acid, combined with other anticancer drugs in leukemic cell lines. Int J Hematol 2004; 79: 37-43.
-
(2004)
Int J Hematol
, vol.79
, pp. 37-43
-
-
Kimura, S.1
Kuroda, J.2
Segawa, H.3
-
41
-
-
33646793674
-
Management of cancer-treatment-induced bone loss in postmenopausal women undergo in adjuvant breast cancer therapy: A Z-FAST update
-
Brufsky A. Management of cancer-treatment-induced bone loss in postmenopausal women undergo in adjuvant breast cancer therapy: A Z-FAST update. Semin. Oncol 2006; 33: S13-S17.
-
(2006)
Semin. Oncol
, vol.33
-
-
Brufsky, A.1
-
42
-
-
33144467615
-
Improving bone health in patients with early breast cancer by adding bisphosphonates to letrozole: The Z-ZO-E-ZO-FAST program
-
Aapro M. Improving bone health in patients with early breast cancer by adding bisphosphonates to letrozole: The Z-ZO-E-ZO-FAST program. Breast 2006; 15: S30-S340.
-
(2006)
Breast
, vol.15
-
-
Aapro, M.1
-
43
-
-
33947524592
-
Zoledronic acid inhibits adjuvant letrozole-induced bone loss in postmenopausal women with early breast cancer
-
Brufsky A, Harker WG, Beck JT et al. Zoledronic acid inhibits adjuvant letrozole-induced bone loss in postmenopausal women with early breast cancer. J Clin Oncol 2007; 25: 829-836.
-
(2007)
J Clin Oncol
, vol.25
, pp. 829-836
-
-
Brufsky, A.1
Harker, W.G.2
Beck, J.T.3
-
44
-
-
5444253259
-
Toward new horizons: The future of bisphosphonate therapy
-
Lipton A. Toward new horizons: The future of bisphosphonate therapy. Oncologist 2004; S4: 38-47.
-
(2004)
Oncologist
, vol.S4
, pp. 38-47
-
-
Lipton, A.1
-
45
-
-
22344455489
-
Randomized, open label, prospective study on the effect of zoledronic acid on the prevention of bone metastases in patients with recurrent solid tumors that did not present with bone metastases at baseline
-
Mystakidou K, Katsouda E, Parpa E et al. Randomized, open label, prospective study on the effect of zoledronic acid on the prevention of bone metastases in patients with recurrent solid tumors that did not present with bone metastases at baseline. Med Oncol 2005; 22: 195-201.
-
(2005)
Med Oncol
, vol.22
, pp. 195-201
-
-
Mystakidou, K.1
Katsouda, E.2
Parpa, E.3
|