-
1
-
-
2442534283
-
Finding New drugs
-
Koppal T. Finding New drugs. Drug Disc. Dev. 9 (2003) 22-28
-
(2003)
Drug Disc. Dev.
, vol.9
, pp. 22-28
-
-
Koppal, T.1
-
2
-
-
19944422452
-
Key aspects of the Novartis Compound Collection Enhancement Project for the compilation of a comprehensive chemogenomics drug discovery screening collection
-
Jacoby E., et al. Key aspects of the Novartis Compound Collection Enhancement Project for the compilation of a comprehensive chemogenomics drug discovery screening collection. Curr. Topics Med. Chem. 5 (2005) 397-411
-
(2005)
Curr. Topics Med. Chem.
, vol.5
, pp. 397-411
-
-
Jacoby, E.1
-
3
-
-
33749234216
-
Drugs, their targets and the nature and number of drug targets
-
Imming P., et al. Drugs, their targets and the nature and number of drug targets. Nat. Rev. Drug Disc. 5 (2006) 821-834
-
(2006)
Nat. Rev. Drug Disc.
, vol.5
, pp. 821-834
-
-
Imming, P.1
-
4
-
-
33751547539
-
How many drug targets are there?
-
Overington J.P., et al. How many drug targets are there?. Nat. Rev. Drug Disc. 5 (2006) 993-998
-
(2006)
Nat. Rev. Drug Disc.
, vol.5
, pp. 993-998
-
-
Overington, J.P.1
-
6
-
-
0038656734
-
G protein coupled receptors: from ligand identification to drug targets
-
Chantry D. G protein coupled receptors: from ligand identification to drug targets. Exp. Opin. Emerg. Drugs 8 (2003) 273-276
-
(2003)
Exp. Opin. Emerg. Drugs
, vol.8
, pp. 273-276
-
-
Chantry, D.1
-
7
-
-
0037267313
-
Knockouts model the 100 best-selling drugs- will they model the next 100?
-
Zambrowicz B.P., and Sands A.T. Knockouts model the 100 best-selling drugs- will they model the next 100?. Nat. Rev. Drug Disc. 2 (2003) 38-51
-
(2003)
Nat. Rev. Drug Disc.
, vol.2
, pp. 38-51
-
-
Zambrowicz, B.P.1
Sands, A.T.2
-
8
-
-
33646754515
-
Therapeutic targets: Progress of their exploration and investigation of their characteristics
-
Zheng C., et al. Therapeutic targets: Progress of their exploration and investigation of their characteristics. Pharmacol. Rev. 58 (2006) 259-279
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 259-279
-
-
Zheng, C.1
-
9
-
-
0038512037
-
Molecular shape diversity of combinatorial libraries: A prerequisite for broad bioactivity
-
Sauer W.H.B., and Schwarz M.K. Molecular shape diversity of combinatorial libraries: A prerequisite for broad bioactivity. J. Chem. Inf. Comput. Sci. 43 (2003) 987-1003
-
(2003)
J. Chem. Inf. Comput. Sci.
, vol.43
, pp. 987-1003
-
-
Sauer, W.H.B.1
Schwarz, M.K.2
-
10
-
-
0038719648
-
Size doesn't matter: Scaffold diversity, shape diversity and biological activity of combinatorial libraries
-
Sauer W.H.B., and Schwarz M.K. Size doesn't matter: Scaffold diversity, shape diversity and biological activity of combinatorial libraries. Chimia 57 (2003) 276-283
-
(2003)
Chimia
, vol.57
, pp. 276-283
-
-
Sauer, W.H.B.1
Schwarz, M.K.2
-
11
-
-
35748945205
-
-
Pipeline Pilot, SciTegic, Inc. 10188 Telesis Court, Suite 100, San Diego, CA 92121, USA, http://www.scitegic.com/products_services/pipeline_pilot.htm
-
-
-
-
12
-
-
29144483936
-
Predicting protein druggability
-
Hajduk P.J., et al. Predicting protein druggability. Drug Discov. Today 10 (2005) 1675-1681
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1675-1681
-
-
Hajduk, P.J.1
-
13
-
-
0037666888
-
Implications of protein flexibility for drug discovery
-
Teague S.J. Implications of protein flexibility for drug discovery. Nat. Rev. Drug Disc. 2 (2003) 527-541
-
(2003)
Nat. Rev. Drug Disc.
, vol.2
, pp. 527-541
-
-
Teague, S.J.1
-
14
-
-
0032112610
-
Conformational energy penalties of protein-bound ligands
-
Bostrom J., et al. Conformational energy penalties of protein-bound ligands. J. Comput. Aided Mol. Des. 12 (1998) 383-396
-
(1998)
J. Comput. Aided Mol. Des.
, vol.12
, pp. 383-396
-
-
Bostrom, J.1
-
15
-
-
0347627364
-
Sequential Ugi/Heck cyclization strategies for the facile construction of highly functionalized N-heterocyclic scaffolds
-
Gracias V., et al. Sequential Ugi/Heck cyclization strategies for the facile construction of highly functionalized N-heterocyclic scaffolds. Tetrahedron Lett. 45 (2004) 417-420
-
(2004)
Tetrahedron Lett.
, vol.45
, pp. 417-420
-
-
Gracias, V.1
-
16
-
-
1842637394
-
Synthesis of novel fused isoxazoles and isoxazolines by sequential Ugi/INOC reactions
-
Akritopoulou-Zanze I., et al. Synthesis of novel fused isoxazoles and isoxazolines by sequential Ugi/INOC reactions. Tetrahedron Lett. 45 (2004) 3421-3423
-
(2004)
Tetrahedron Lett.
, vol.45
, pp. 3421-3423
-
-
Akritopoulou-Zanze, I.1
-
17
-
-
4644245828
-
Synthesis of diazepinones via intramolecular transamidation
-
Vasudevan A., et al. Synthesis of diazepinones via intramolecular transamidation. Org. Lett. 6 (2004) 3361-3364
-
(2004)
Org. Lett.
, vol.6
, pp. 3361-3364
-
-
Vasudevan, A.1
-
18
-
-
0036254461
-
A novel approach to combinatorial library design
-
Nilakantan R., et al. A novel approach to combinatorial library design. Comb. Chem. High Throughput Screen. 5 (2002) 105-110
-
(2002)
Comb. Chem. High Throughput Screen.
, vol.5
, pp. 105-110
-
-
Nilakantan, R.1
-
19
-
-
1542724421
-
Design of a compound screening collection for use in high throughput screening
-
Harper G., et al. Design of a compound screening collection for use in high throughput screening. Comb. Chem. High Throughput Screen. 7 (2004) 63-71
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, pp. 63-71
-
-
Harper, G.1
-
20
-
-
0037119336
-
From protein domains to drug candidates
-
Breinbauer R., et al. From protein domains to drug candidates. Angew. Chem., Int. Ed. 41 (2002) 2878-2890
-
(2002)
Angew. Chem., Int. Ed.
, vol.41
, pp. 2878-2890
-
-
Breinbauer, R.1
-
21
-
-
28944443244
-
Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC)
-
Balamurugan R., et al. Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC). Molecular BioSystems 1 (2005) 36-45
-
(2005)
Molecular BioSystems
, vol.1
, pp. 36-45
-
-
Balamurugan, R.1
-
22
-
-
34547673017
-
Comparison of topological, shape, and docking methods in virtual screening
-
McGaughey G.B., et al. Comparison of topological, shape, and docking methods in virtual screening. J. Chem. Inf. Model. 47 (2007) 1504-1519
-
(2007)
J. Chem. Inf. Model.
, vol.47
, pp. 1504-1519
-
-
McGaughey, G.B.1
-
23
-
-
19544389524
-
Real spherical harmonic expansion coefficients as 3D shape descriptors for protein binding pocket and ligand comparisons
-
Morris R.J., et al. Real spherical harmonic expansion coefficients as 3D shape descriptors for protein binding pocket and ligand comparisons. Bioinformatics 21 (2005) 2347-2355
-
(2005)
Bioinformatics
, vol.21
, pp. 2347-2355
-
-
Morris, R.J.1
-
24
-
-
35748978272
-
-
ROCS, version 2.2, OpenEye Scientific Software, Inc., Santa Fe, NM, USA, 2007 http://www.eyesopen.com
-
-
-
-
25
-
-
35748963283
-
-
EON version 1.1, OpenEye Scientific Software, Inc., Santa Fe, NM, USA, 2007 http://www.eyesopen.com
-
-
-
-
26
-
-
35748975452
-
-
PARASURF, Clark, T. et al. ParaSurf'06, Universitaet Erlangen-Nuernberg and Cepos InSilico Ltd., Ryde, UK, 2006, http://www.ceposinsilico.de/
-
-
-
|