Synthesis of novel fused isoxazoles and isoxazolines by sequential Ugi/INOC reactions

Tetrahedron Letters

Volumn 45, Issue 17, 2004, Pages 3421-3423

  Akritopoulou Zanze, Irini ^a   Gracias, Vijaya ^a   Moore, Joel D ^a   Djuric, Stevan W ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Fused rings; INOC; Isoxazoles; Isoxazolines; Sequential multicomponent reactions; Ugi

Indexed keywords

ISOXAZOLE DERIVATIVE; ISOXAZOLINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; REACTION ANALYSIS; SYNTHESIS;

EID: 1842637394     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.03.016     Document Type: Article

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22. 6 ): δ ppm 8.68 (s, 1H, H3), 8.23 (d, J=7.80 Hz, 1H, NH), 7.42-7.34 (m, 3H, H2″, H3″), 7.25-7.23 (m, 2H, H1″), 6.32 (s, 1H, H2), 4.67 (d, J=14.97 Hz, 1H, H4), 3.84 (d, J=15 Hz, 1H, H4), 3.82 (s, 2H, H7), 3.65-3.59 (m, 1H, H1′), 1.80-1.63 (m, 4H, H2′, H3′), 1.56-1.53 (m, 1H, H4′), 1.27-1.06 (m, 5H, H2′, H3′, H4′). MS (ESI, M + H) 354. NOEs were observed between H3/H4, H4/H1″, H4/H2, H2/NH and H2/H1″