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Volumn 90, Issue 3, 2007, Pages 1506-1515

Feeding rumen-inert fats differing in their degree of saturation decreases intake and increases plasma concentrations of gut peptides in lactating dairy cows

Author keywords

Dietary fat; Gut peptide; Intake; Saturation

Indexed keywords

BOS;

EID: 35748930846     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.S0022-0302(07)71636-3     Document Type: Article
Times cited : (123)

References (47)
  • 1
    • 0034219158 scopus 로고    scopus 로고
    • Effects of diet on short-term regulation of feed intake by lactating dairy cattle
    • Allen, M. S. 2000. Effects of diet on short-term regulation of feed intake by lactating dairy cattle. J. Dairy Sci. 83:1598-1624.
    • (2000) J. Dairy Sci , vol.83 , pp. 1598-1624
    • Allen, M.S.1
  • 2
    • 0022455967 scopus 로고
    • Effect of dietary saturated fatty acids on hormone-sensitive lipolysis in rat adipocytes
    • Awad, A. B., and J. P. Chattopadhyay. 1986. Effect of dietary saturated fatty acids on hormone-sensitive lipolysis in rat adipocytes. J. Nutr. 116:1088-1094.
    • (1986) J. Nutr , vol.116 , pp. 1088-1094
    • Awad, A.B.1    Chattopadhyay, J.P.2
  • 3
    • 0041864180 scopus 로고    scopus 로고
    • Nutritional regulation of milk fat synthesis
    • Bauman, D. E., and J. M. Griinari. 2003. Nutritional regulation of milk fat synthesis. Annu. Rev. Nutr. 23:203-227.
    • (2003) Annu. Rev. Nutr , vol.23 , pp. 203-227
    • Bauman, D.E.1    Griinari, J.M.2
  • 4
    • 22144465559 scopus 로고    scopus 로고
    • Nutrient digestibility of diets with different fiber to starch ratios when fed to lactating dairy cows
    • Beckman, J. L., and W. P. Weiss. 2005. Nutrient digestibility of diets with different fiber to starch ratios when fed to lactating dairy cows. J. Dairy Sci. 88:1015-1023.
    • (2005) J. Dairy Sci , vol.88 , pp. 1015-1023
    • Beckman, J.L.1    Weiss, W.P.2
  • 5
    • 0035374842 scopus 로고    scopus 로고
    • Effects of abomasal infusion of long-chain fatty acids on splanchnic metabolism of pancreatic and gut hormones in lactating dairy cows
    • Benson, J. A., and C. K. Reynolds. 2001. Effects of abomasal infusion of long-chain fatty acids on splanchnic metabolism of pancreatic and gut hormones in lactating dairy cows. J. Dairy Sci. 84:1488-1500.
    • (2001) J. Dairy Sci , vol.84 , pp. 1488-1500
    • Benson, J.A.1    Reynolds, C.K.2
  • 6
    • 0036653396 scopus 로고    scopus 로고
    • Effects of abomasal long chain fatty acid infusion on splanchnic nutrient metabolism in lactating dairy cows
    • Benson, J. A., C. K. Reynolds, P. C. Aikman, B. Lupoli, and D. E. Beever. 2002. Effects of abomasal long chain fatty acid infusion on splanchnic nutrient metabolism in lactating dairy cows. J. Dairy Sci. 85:1804-1814.
    • (2002) J. Dairy Sci , vol.85 , pp. 1804-1814
    • Benson, J.A.1    Reynolds, C.K.2    Aikman, P.C.3    Lupoli, B.4    Beever, D.E.5
  • 7
    • 0035345437 scopus 로고    scopus 로고
    • Effects of abomasal infusion of long-chain fatty acids on intake, feeding behavior and milk production in dairy cows
    • Benson, J. A., C. K. Reynolds, D. J. Humphries, S. M. Rutter, and D. E. Beever. 2001. Effects of abomasal infusion of long-chain fatty acids on intake, feeding behavior and milk production in dairy cows. J. Dairy Sci. 84:1182-1191.
    • (2001) J. Dairy Sci , vol.84 , pp. 1182-1191
    • Benson, J.A.1    Reynolds, C.K.2    Humphries, D.J.3    Rutter, S.M.4    Beever, D.E.5
  • 8
    • 0036434385 scopus 로고    scopus 로고
    • Interaction between specific fatty acids, GLP-I and insulin secretion in humans
    • Beysen, C., F. Karpe, B. A. Fielding, A. Clark, J. C. Levy, and K. N. Frayn. 2002. Interaction between specific fatty acids, GLP-I and insulin secretion in humans. Diabetologia 45:1533-1541.
    • (2002) Diabetologia , vol.45 , pp. 1533-1541
    • Beysen, C.1    Karpe, F.2    Fielding, B.A.3    Clark, A.4    Levy, J.C.5    Frayn, K.N.6
  • 9
    • 4043146461 scopus 로고    scopus 로고
    • Effects of feeding or abomasal infusion of canola oil in Holstein cows. 2. Gene expression and plasma concentrations of cholecystokinin and leptin
    • Chelikani, P. K., D. R. Glimm, D. H. Keisler, and J. J. Kennelly. 2004. Effects of feeding or abomasal infusion of canola oil in Holstein cows. 2. Gene expression and plasma concentrations of cholecystokinin and leptin. J. Dairy Res. 71:288-296.
    • (2004) J. Dairy Res , vol.71 , pp. 288-296
    • Chelikani, P.K.1    Glimm, D.R.2    Keisler, D.H.3    Kennelly, J.J.4
  • 10
    • 0029861846 scopus 로고    scopus 로고
    • High fat diets increase plasma cholecystokinin and pancreatic polypeptide, and decrease plasma insulin and feed intake in lactating cows
    • Choi, B. R., and D. L. Palmquist. 1996. High fat diets increase plasma cholecystokinin and pancreatic polypeptide, and decrease plasma insulin and feed intake in lactating cows. J. Nutr. 126:2913-2919.
    • (1996) J. Nutr , vol.126 , pp. 2913-2919
    • Choi, B.R.1    Palmquist, D.L.2
  • 11
    • 0033758541 scopus 로고    scopus 로고
    • Cholecystokinin mediates depression of feed intake in dairy cattle fed high fat diets
    • Choi, B. R., D. L. Palmquist, and M. S. Allen. 2000. Cholecystokinin mediates depression of feed intake in dairy cattle fed high fat diets. Dornest. Anim. Endocrinol. 19:159-175.
    • (2000) Dornest. Anim. Endocrinol , vol.19 , pp. 159-175
    • Choi, B.R.1    Palmquist, D.L.2    Allen, M.S.3
  • 12
    • 0031991707 scopus 로고    scopus 로고
    • Fatty acid profile and physical properties of milk fat from cows fed calcium salts of fatty acids with varying unsaturation
    • Chouinard, P. Y., V. Girard, and G. J. Brisson. 1998. Fatty acid profile and physical properties of milk fat from cows fed calcium salts of fatty acids with varying unsaturation. J. Dairy Sci. 81:471-481.
    • (1998) J. Dairy Sci , vol.81 , pp. 471-481
    • Chouinard, P.Y.1    Girard, V.2    Brisson, G.J.3
  • 13
    • 0031732608 scopus 로고    scopus 로고
    • Glucagon-likepeptide-1 secretion from canine L-cells is increased by glucosedependent-insulinotropic peptide but unaffected by glucose
    • Damholt, A. B., A. M. Buchan, and H. Kofod. 1998. Glucagon-likepeptide-1 secretion from canine L-cells is increased by glucosedependent-insulinotropic peptide but unaffected by glucose. Endocrinology 139:2085-2091.
    • (1998) Endocrinology , vol.139 , pp. 2085-2091
    • Damholt, A.B.1    Buchan, A.M.2    Kofod, H.3
  • 14
    • 0026876737 scopus 로고
    • Infusion of long-chain fatty acids varying in saturation and chain length into the abomasum of lactating dairy cows
    • Drackley, J. K., T. H. Klusmeyer, A. M. Trusk, and J. H. Clark. 1992. Infusion of long-chain fatty acids varying in saturation and chain length into the abomasum of lactating dairy cows. J. Dairy Sci. 75:1517-1526.
    • (1992) J. Dairy Sci , vol.75 , pp. 1517-1526
    • Drackley, J.K.1    Klusmeyer, T.H.2    Trusk, A.M.3    Clark, J.H.4
  • 15
    • 0033081175 scopus 로고    scopus 로고
    • Insulin secretion and intestinal peptides during lactation in sheep
    • Faulkner, A., and P. A. Martin. 1999. Insulin secretion and intestinal peptides during lactation in sheep. J. Dairy Res. 66:45-52.
    • (1999) J. Dairy Res , vol.66 , pp. 45-52
    • Faulkner, A.1    Martin, P.A.2
  • 16
    • 0028488871 scopus 로고
    • Assessment of the effects of iodine value on fatty acid digestibility, feed intake, and milk production
    • Firkins, J. L., and M. L. Eastridge. 1994. Assessment of the effects of iodine value on fatty acid digestibility, feed intake, and milk production. J. Dairy Sci. 77:2357-2366.
    • (1994) J. Dairy Sci , vol.77 , pp. 2357-2366
    • Firkins, J.L.1    Eastridge, M.L.2
  • 17
    • 0942279569 scopus 로고    scopus 로고
    • Energy homeostasis, obesity and eating disorders: Recent advances in endocrinology
    • Gale, S. M., V. D. Castracane, and C. S. Mantzoros. 2004. Energy homeostasis, obesity and eating disorders: Recent advances in endocrinology. J. Nutr. 134:295-298.
    • (2004) J. Nutr , vol.134 , pp. 295-298
    • Gale, S.M.1    Castracane, V.D.2    Mantzoros, C.S.3
  • 18
    • 0030253688 scopus 로고    scopus 로고
    • Soybeans versus animal sources of rumen-undegradable protein and fat for early lactation dairy cows
    • Grummer, R. R., K. Slark, S. J. Bertics, M. L. Luck, and J. A. Barmore. 1996. Soybeans versus animal sources of rumen-undegradable protein and fat for early lactation dairy cows. J. Dairy Sci. 79:1809-1816.
    • (1996) J. Dairy Sci , vol.79 , pp. 1809-1816
    • Grummer, R.R.1    Slark, K.2    Bertics, S.J.3    Luck, M.L.4    Barmore, J.A.5
  • 19
    • 27644551442 scopus 로고    scopus 로고
    • The effect of production level on feed intake, milk yield, and endocrine responses to two fatty acid supplements in lactating cows
    • Harvatine, K. J., and M. S. Allen. 2005. The effect of production level on feed intake, milk yield, and endocrine responses to two fatty acid supplements in lactating cows. J. Dairy Sci. 88:4018-4027.
    • (2005) J. Dairy Sci , vol.88 , pp. 4018-4027
    • Harvatine, K.J.1    Allen, M.S.2
  • 20
    • 33644844183 scopus 로고    scopus 로고
    • Fat supplements affect fractional rates of ruminal biohydrogenation and passage in dairy cows
    • Harvatine, K. J., and M. S. Allen. 2006. Fat supplements affect fractional rates of ruminal biohydrogenation and passage in dairy cows. J. Nutr. 136:677-685.
    • (2006) J. Nutr , vol.136 , pp. 677-685
    • Harvatine, K.J.1    Allen, M.S.2
  • 22
    • 0030901415 scopus 로고    scopus 로고
    • Enteroglucagon
    • Holst, J. J. 1997. Enteroglucagon. Annu. Rev. Physiol. 59:257-271.
    • (1997) Annu. Rev. Physiol , vol.59 , pp. 257-271
    • Holst, J.J.1
  • 23
    • 0024676739 scopus 로고
    • Techniques for measuring blood flow in splanchnic tissues of cattle
    • Huntington, G. B., C. K. Reynolds, andB. H. Stroud. 1989. Techniques for measuring blood flow in splanchnic tissues of cattle. J. Dairy Sci. 72:1583-1595.
    • (1989) J. Dairy Sci , vol.72 , pp. 1583-1595
    • Huntington, G.B.C.K.1    Reynolds2    andB3    Stroud, H.4
  • 24
    • 0034221867 scopus 로고    scopus 로고
    • Integration of metabolism and intake regulation: A review focusing on periparturient animals
    • Ingvartsen, K. L., and J. B. Andersen. 2000. Integration of metabolism and intake regulation: A review focusing on periparturient animals. J. Dairy Sci. 83:1573-1597.
    • (2000) J. Dairy Sci , vol.83 , pp. 1573-1597
    • Ingvartsen, K.L.1    Andersen, J.B.2
  • 25
    • 0027569848 scopus 로고
    • Technical note: An improved method to quantify nonesterified fatty acids in bovine plasma
    • Johnson, M. M., and J. P. Peters. 1993. Technical note: An improved method to quantify nonesterified fatty acids in bovine plasma. J. Anim. Sci. 71:753-756.
    • (1993) J. Anim. Sci , vol.71 , pp. 753-756
    • Johnson, M.M.1    Peters, J.P.2
  • 26
    • 0030093033 scopus 로고    scopus 로고
    • Nutrientinduced secretion and metabolic effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1
    • Knapper, J. M. E., L. M. Morgan, and J. M. Fletcher. 1996. Nutrientinduced secretion and metabolic effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. Proc. Nutr. Soc. 55:291-305.
    • (1996) Proc. Nutr. Soc , vol.55 , pp. 291-305
    • Knapper, J.M.E.1    Morgan, L.M.2    Fletcher, J.M.3
  • 27
    • 0030661916 scopus 로고    scopus 로고
    • Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on conjugated dienes and total trans fatty acids
    • Kramer, J. K., V. Fellner, M. E. Dugan, F. D. Sauer, M. M. Mossoba, and M. P. Yurawecz. 1997. Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on conjugated dienes and total trans fatty acids. Lipids 32:1219-1228.
    • (1997) Lipids , vol.32 , pp. 1219-1228
    • Kramer, J.K.1    Fellner, V.2    Dugan, M.E.3    Sauer, F.D.4    Mossoba, M.M.5    Yurawecz, M.P.6
  • 28
    • 35748936219 scopus 로고    scopus 로고
    • Cholesytokinin mediates intake regulation of high fat diets in ruminants by acting on the reticulo-omasal sphincter
    • Abstr
    • Kumar, D., M. A. Foetschel, T. D. Pringle, and D. H. Keisler. 2004. Cholesytokinin mediates intake regulation of high fat diets in ruminants by acting on the reticulo-omasal sphincter. J. Dairy Sci. 87(Suppl. 1):309. (Abstr.)
    • (2004) J. Dairy Sci , vol.87 , Issue.SUPPL. 1 , pp. 309
    • Kumar, D.1    Foetschel, M.A.2    Pringle, T.D.3    Keisler, D.H.4
  • 29
    • 15044346747 scopus 로고    scopus 로고
    • Dry matter intake is decreased more by abomasal infusion of unsaturated free fatty acids than by unsaturated triglycerides
    • Litherland, N. B., S. Thire, A. D. Beaulieu, C. K. Reynolds, J. A. Benson, and J. K. Drackley. 2005. Dry matter intake is decreased more by abomasal infusion of unsaturated free fatty acids than by unsaturated triglycerides. J. Dairy Sci. 88:632-643.
    • (2005) J. Dairy Sci , vol.88 , pp. 632-643
    • Litherland, N.B.1    Thire, S.2    Beaulieu, A.D.3    Reynolds, C.K.4    Benson, J.A.5    Drackley, J.K.6
  • 31
    • 4243077616 scopus 로고    scopus 로고
    • Ruminal biohydrogenation in Holstein cows fed soybean fatty acids as amides or calcium salts
    • Lundy, F. P., E. Block, W. C. Bridges, Jr., J. A. Bertrand, and T. C. Jenkins. 2004. Ruminal biohydrogenation in Holstein cows fed soybean fatty acids as amides or calcium salts. J. Dairy Sci. 87:1038-1046.
    • (2004) J. Dairy Sci , vol.87 , pp. 1038-1046
    • Lundy, F.P.1    Block, E.2    Bridges Jr., W.C.3    Bertrand, J.A.4    Jenkins, T.C.5
  • 32
    • 0027260416 scopus 로고
    • Effects of consumption of milk and milk constituents on plasma concentrations of gastric inhibitory polypeptide and metabolites in preruminant goat kids
    • Martin, P. A., A. Faulkner, and J. P. McCarthy. 1993. Effects of consumption of milk and milk constituents on plasma concentrations of gastric inhibitory polypeptide and metabolites in preruminant goat kids. J. Endocrinol. 138:167-173.
    • (1993) J. Endocrinol , vol.138 , pp. 167-173
    • Martin, P.A.1    Faulkner, A.2    McCarthy, J.P.3
  • 33
    • 3242742898 scopus 로고    scopus 로고
    • Gut peptides in the control of food intake: 30 years of ideas
    • Moran, T. H. 2004. Gut peptides in the control of food intake: 30 years of ideas. Physiol. Behav. 82:175-180.
    • (2004) Physiol. Behav , vol.82 , pp. 175-180
    • Moran, T.H.1
  • 34
    • 0017806161 scopus 로고
    • Radioimmunoassay of gastric inhibitory polypeptide
    • Morgan, L. M., B. A. Morris, and V. Marks. 1978. Radioimmunoassay of gastric inhibitory polypeptide. Ann. Clin. Biochem. 15:172-177.
    • (1978) Ann. Clin. Biochem , vol.15 , pp. 172-177
    • Morgan, L.M.1    Morris, B.A.2    Marks, V.3
  • 35
    • 85031438870 scopus 로고    scopus 로고
    • NRC, 7th rev. ed. Natl. Acad. Sci, Washington, DC
    • NRC. 2001. Nutrient Requirements of Dairy Cattle. 7th rev. ed. Natl. Acad. Sci., Washington, DC.
    • (2001) Nutrient Requirements of Dairy Cattle
  • 36
    • 84885693488 scopus 로고    scopus 로고
    • Milk fat: Origin of fatty acids and influence of nutritional factors thereon
    • Lipids. P. F. Fox and P. L. H. McSweeney, ed. Springer, New York, NY
    • Palmquist, D. L. 2006. Milk fat: Origin of fatty acids and influence of nutritional factors thereon. Pages 43-92 in Advanced Dairy Chemistry. Vol. 2: Lipids. P. F. Fox and P. L. H. McSweeney, ed. Springer, New York, NY.
    • (2006) Advanced Dairy Chemistry , vol.2 , pp. 43-92
    • Palmquist, D.L.1
  • 37
    • 29144475885 scopus 로고    scopus 로고
    • Processing whole cottonseed moderates fatty acid metabolism and improves performance by dairy cows
    • Reveneau, C., C. V. D. M. Ribeiro, M. L. Eastridge, N. R. St-Pierre, and J. L. Firkins. 2005. Processing whole cottonseed moderates fatty acid metabolism and improves performance by dairy cows. J. Dairy Sci. 88:4342-4355.
    • (2005) J. Dairy Sci , vol.88 , pp. 4342-4355
    • Reveneau, C.1    Ribeiro, C.V.D.M.2    Eastridge, M.L.3    St-Pierre, N.R.4    Firkins, J.L.5
  • 38
    • 0024676891 scopus 로고
    • Net metabolism of hormones by portaldrained viscera and liver of lactating Holstein cows
    • Reynolds, C. K., G. B. Huntington, T. H. Elsasser, H. F. Tyrrell, and P. J. Reynolds. 1989. Net metabolism of hormones by portaldrained viscera and liver of lactating Holstein cows. J. Dairy Sci. 72:1459-1468.
    • (1989) J. Dairy Sci , vol.72 , pp. 1459-1468
    • Reynolds, C.K.1    Huntington, G.B.2    Elsasser, T.H.3    Tyrrell, H.F.4    Reynolds, P.J.5
  • 39
    • 0036288330 scopus 로고    scopus 로고
    • Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans
    • Robertson, M. D., K. G. Jackson, B. A. Fielding, L. M. Morgan, C. M. Williams, and K. N. Frayn. 2002. Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans. Am. J. Clin. Nutr. 76:232-238.
    • (2002) Am. J. Clin. Nutr , vol.76 , pp. 232-238
    • Robertson, M.D.1    Jackson, K.G.2    Fielding, B.A.3    Morgan, L.M.4    Williams, C.M.5    Frayn, K.N.6
  • 40
    • 0001856929 scopus 로고    scopus 로고
    • Profiles of the hormones somatostatin, gastrin, CCK, prolactin, growth hormone and Cortisol. I. In dairy cows that are milked and fed separately or milked and fed simultaneously
    • Samuelsson, B., K. Uvnäs-Moberg, R. C. Gorewit, and K. Svennersten-Sjaunja. 1996. Profiles of the hormones somatostatin, gastrin, CCK, prolactin, growth hormone and Cortisol. I. In dairy cows that are milked and fed separately or milked and fed simultaneously. Livest. Prod. Sci. 46:49-56.
    • (1996) Livest. Prod. Sci , vol.46 , pp. 49-56
    • Samuelsson, B.1    Uvnäs-Moberg, K.2    Gorewit, R.C.3    Svennersten-Sjaunja, K.4
  • 41
    • 85031436203 scopus 로고    scopus 로고
    • SAS Institute. 2000. The SAS System for Windows. Release 8.1. SAS Institute, Inc, Cary, NC
    • SAS Institute. 2000. The SAS System for Windows. Release 8.1. SAS Institute, Inc., Cary, NC.
  • 42
    • 0026951378 scopus 로고
    • Effects of feeding diets containing calcium salts of long-chain fatty acids to lactating dairy cows
    • Schauff, D. J., and J. H. Clark. 1992. Effects of feeding diets containing calcium salts of long-chain fatty acids to lactating dairy cows. J. Dairy Sci. 75:2990-3002.
    • (1992) J. Dairy Sci , vol.75 , pp. 2990-3002
    • Schauff, D.J.1    Clark, J.H.2
  • 43
    • 0023266561 scopus 로고
    • Identification and localization of glucagon-like peptide-1 and its receptor in rat brain
    • Shimizu, I., M. Hirota, C. Ohboshi, and K. Shima. 1987. Identification and localization of glucagon-like peptide-1 and its receptor in rat brain. Endocrinology 121:1076-1082.
    • (1987) Endocrinology , vol.121 , pp. 1076-1082
    • Shimizu, I.1    Hirota, M.2    Ohboshi, C.3    Shima, K.4
  • 44
    • 0025458372 scopus 로고
    • Dissociation of calcium soaps of long-chain fatty acids in rumen fluid
    • Sukhija, P. S., and D. L. Palmquist. 1990. Dissociation of calcium soaps of long-chain fatty acids in rumen fluid. J. Dairy Sci. 73:1784-1787.
    • (1990) J. Dairy Sci , vol.73 , pp. 1784-1787
    • Sukhija, P.S.1    Palmquist, D.L.2
  • 45
    • 0029083454 scopus 로고
    • Role of endogenous CCK in regulation of interdigestive pancreatic exocrine secretion in sheep (Ovis aries)
    • Tachibana, S., T. Onaga, H. Mineo, and S. Kato. 1995. Role of endogenous CCK in regulation of interdigestive pancreatic exocrine secretion in sheep (Ovis aries). Comp. Biochem. Physiol. A Physiol. 112:103-109.
    • (1995) Comp. Biochem. Physiol. A Physiol , vol.112 , pp. 103-109
    • Tachibana, S.1    Onaga, T.2    Mineo, H.3    Kato, S.4
  • 46
    • 0032975814 scopus 로고    scopus 로고
    • Differential effects of saturated and monounsaturated fatty acids on postprandial Iipemia and incretin responses in healthy subjects
    • Thomsen, C., O. Rasmussen, T. Lousen, J. J. Hoist, S. Fenselau, J. Schrezenmeir, and K. Hermansen. 1999. Differential effects of saturated and monounsaturated fatty acids on postprandial Iipemia and incretin responses in healthy subjects. Am. J. Clin. Nutr. 69:1135-1143.
    • (1999) Am. J. Clin. Nutr , vol.69 , pp. 1135-1143
    • Thomsen, C.1    Rasmussen, O.2    Lousen, T.3    Hoist, J.J.4    Fenselau, S.5    Schrezenmeir, J.6    Hermansen, K.7


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