Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects

American Journal of Clinical Nutrition

Volumn 69, Issue 6, 1999, Pages 1135-1143

  Thomsen, Claus ^a   Rasmussen, Ole ^b   Lousen, Thea ^b   Holst, Jens J ^b   Fenselau, Susanne ^b   Schrezenmeir, Jürgen ^b   Hermansen, Kjeld ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

Adults; Gastric inhibitory polypeptide; GIP; GLP 1; Glucagon like peptide 1; HDL cholesterol; Humans; Incretins; Lipemia; Monounsaturated fat; Oleic acid; Olive oil; Postprandial phase; Saturated fat; Triacylglycerol

Indexed keywords

CHYLOMICRON; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LIPOPROTEIN; MONOUNSATURATED FATTY ACID; OLEIC ACID; OLIVE OIL; RETINOL PALMITATE; SATURATED FATTY ACID; TRIACYLGLYCEROL;

ADULT; ARTICLE; BUTTER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FAT INTAKE; FATTY ACID METABOLISM; FEMALE; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; HYPERLIPIDEMIA; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL; TEST MEAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0032975814     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/69.6.1135     Document Type: Article

References (48)

1. 2 into high density lipoprotein, by hepatic lipase. J Clin Invest 1984;74:2017-23.
2. Patsch JR, Miesenböck G, Hopherwieser T, et al. Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler Thromb 1992;12:1336-45.
3. Miesenböck G, Patsch JR. Synergy of triglyceride-rich lipoproteins and HDL. Cardiovasc Risk Factors 1991;1:293-9.
4. Schrezenmeir J, Keppler I, Fenselau S, et al. The phenomenon of a high triglyceride response to an oral lipid load in healthy subjects and its link to the metabolic syndrome. In: Dietary lipids and insulin action. Ann N Y Acad Sci 1993;683:302-14.
5. Schrezenmeir J, Fenselau S, Keppler I, et al. Postprandial triglyceride high response and the metabolic syndrome. In: Lipids and syndromes of insulin resistance. Ann N Y Acad Sci 1997;827:353-68.
6. Grundy SM. Comparison of monounsaturated fatly acids and carbohydrates for lowering plasma cholesterol. N Engl J Med 1986;314:745-8.
7. Mensink RP, Katan MB. Effects of monounsaturated fatty acids vs. complex carbohydrates on high-density lipoproteins in healthy men and women. Lancet 1987;1:122-5.
8. Mattson FH, Grundy SM. Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J Lipid Res 1985;26:194-202.
9. Grundy SM, Florentin L, Nix D, Whelan MF. Comparison of monounsaturated fatty acids and carbohydrates for reducing raised levels of plasma cholesterol in man. Am J Clin Nutr 1988;47:965-9.
10. Grundy SM, Vega GL. Plasma cholesterol responsiveness to saturated fatty acids. Am J Clin Nutr 1988;47:822-4.
11. de Bruin TWA, Brouwer CB, Gimpel JA, Erkelens DW. Postprandial decrease in HDL cholesterol and HDL apo A-I in normal subjects in relation to triglyceride metabolism. Am J Physiol 1991;260:E492-8.
12. de Bruin TWA, Brouwer CB, van Linde-Sibenius Trip M, Jansen H, Erkelens DW. Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil. Am J Clin Nutr 1993;58:477-83.
13. Higashi K, Ishikawa T, Shige H, et al. Olive oil increases the magnitude of postprandial chylomicron remnants compared to milk and safflower oil. J Am Coll Nutr 1997;16:429-34.
14. Rasmussen O, Lauszus FF, Christiansen C, Thomsen C, Hermansen K. Differential effects of saturated and monounsaturated fat on blood glucose and insulin responses in subjects with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1996;63:249-53.
15. Egan JM, Montrose Rafizadeh C, Wang Y, Bernier M, Roth J. Glucagon-like peptide-1 (7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action. Endocrinology 1994;135:2070-5.
16. Rocca AS, Brubaker PL. Stereospecific effects of fatty acids on proglucagon-derived peptide secretion in fetal rat intestinal cultures. Endocrinology 1995;136:5593-9.
17. Pellett PL. Food energy requirements in humans. Am J Clin Nutr 1990;51:711-22.
18. Blomhoff R, Green MH, Green JB, Berg T, Norum KR. Vitamin A metabolism: new perspectives on absorption, transport and storage. Physiol Rev 1991;71:951-90.
19. Chen YD, Reaven GM. Intestinally derived lipoproteins; metabolism and clinical significance. Diabetes Metab Rev 1991;7:191-208.
20. Ross A, Zilbersmit DB. Use of esterified retinol to trace the degradation of chylomicrons in cholesterol-fed rabbits. Adv Exp Med Biol 1977;82:142-5.
21. Hazzard WR, Bierman EL. Delayed clearance of chylomicron remnants following vitamin A-containing oral fat loads in broad-β disease (type in hyperlipoproteinemia). Metabolism 1976;25:777-801.
22. Andersen L, Dinesen B, Jørgensen PN, Poulsen F, Røder ME. Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem 1993;39:578-82.
23. Krarup T, Madsbad S, Mody AJ, et al. Diminished immunoreactive gastric inhibitory polypeptide response to a meal in newly diagnosed type 1 (insulin dependent) diabetics. J Clin Endocrinol Metab 1983;56:1306-12.
24. Hvidberg A, Nielsen MT, Hilsted J, Ørskov C, Hoist JJ. Effect of glucagon-like peptide-1 (proglucagon 78-107 amide) on hepatic glucose production in healthy man. Metabolism 1994;43:104-8.
25. Ørskov C, Jeppesen J, Madsbad S, Hoist JJ. Proglucagon products in plasma from non-insulin dependent diabetics and non-diabetic controls in the fasting state and following oral glucose and intravenous arginine. J Clin Invest 1991;87:415-23.
26. Ørskov C, Kofod H, Rabenhøj L. Structure of human GLP-1 (glucagon-like peptide-1) containing peptides. Diabetologia 1992;35:A109 (abstr).
27. Biesalki HK. Separation of retinyl esters and their geometric isomers by isocratic adsorption high-performance liquid chromatography. Methods Enzymol 1997;189:83-91.
28. Schrezenmeir J, Weber P, Probst R, et al. Postprandial pattern of triglyceride-rich lipoprotein in normal-weight humans after an oral lipid load: exaggerated triglycerides and altered insulin response in some subjects. Ann Nutr Metab 1992;36:186-96.
29. Matthews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. Br Med J 1990;300:230-5.
30. Gatti E, Noe' D, Pazzucconi F, et al. Differential effects of unsaturated oils and butter on blood glucose and insulin response to carbohydrate in normals. Eur J Clin Nutr 1992;46:161-5.
31. Dupre J, Ross A, Watson D, Brown JC. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 1973;37:826-8.
32. Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987;2:1300-4.
33. Knapper JM, Heath A, Fletcher JM, Morgan LM, Marks V. GIP and GLP-1(7-36)amide secretion in response to intraduodenal infusions of nutrients in pigs. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1995;111:445-50.
34. Hunt JN, Knox MT. Regulation of gastric emptying. Section 6: alimentary canal. In: Cook CF, ed. Handbook of physiology. Washington, DC: American Physiological Society, 1968;1917-36.
35. Chait A, Lewis B, February AW, Mattock M. Functional overlap between 'chylomicra' and 'VLDL' of human plasma during alimentary lipemia. Atherosclerosis 1973;17:455-62.
36. Krasinski SD, Conn JS, Russell RM, Schaefer EJ. Postprandial plasma vitamin A metabolism in humans: a reassessment of the use of plasma retinyl esters as markers for intestinally derived chylomicrons and their remnants. Metabolism 1990;39:357-65.
37. Karpe F, Bell M, Björkegren J, Hamsten A. Quantification of post-prandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of lipoproteins of apolipoproteins B-48 and B-100. Arterioscler Thromb Vase Biol 1995;15:199-207.
38. Knapper JM, Puddicombe SM, Morgan LM, Fletcher JM. Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (7-36) amide on lipoprotein lipase activity in explants of rat adipose tissue. J Nutr 1995;125:183-8.
39. Murphy MC, Isherwood SG, Sehti S, et al. Postprandial lipid and hormone responses to meals of varying fat contents: modulatory role of lipoprotein lipase? Eur J Clin Nutr 1995;49:579-88.
40. Cohn JS, McNamara JR, Krasinski SD, Russell RM, Schaefer EJ. Role of triglyceride-rich lipoproteins from the liver and intestine on the etiology of postprandial peaks in plasma triglyceride concentration. Metabolism 1989;38:484-90.
41. 13P-labeled stearic, oleic and linoleic acids in humans: applications to breath tests. J Lab Clin Med 1985;105:541-51.
42. Miesenböck G, Patsch JR. Postprandial hypelipidemia: the search for the atherogenetic lipoprotein. Curr Opin Lipidol 1992;3:196-201.
43. Brown MS, Herz J, Kowal RC, Goldstein JL. The low-density lipoprotein receptor-related protein: double agent or decoy? Curr Opin Lipidol 1991;2:65-72.
44. Patsch W, Gotto AMJ, Patsch JR. The effects of insulin on lipoprotein secretion in rat hepatocyte cultures: the role of the insulin receptor. J Biol Chem 1986;261:9603-6.
45. Ørskov L, Holst JJ, Møller J, et al. GLP-1 does not acutely affect insulin sensitivity in healthy man. Diabetologia 1996;39:1227-32.
46. Brunzell JD, Hazzard WR, Porte D, Bierman EL. Evidence for a common, saturable triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man. J Clin Invest 1973;52:1578-85.
47. Grundy SM, Mok HYI. Chylomicron clearance in normal and hyperlipidemic man. Metabolism 1976;25:1225-39.
48. Griffiths J, Humphreys SH, Clark ML, Fielding BA, Frayn KN. Immediate metabolic availability of dietary fat in combination with carbohydrate. Am J Clin Nutr 1994;59:53-9.