Neuroimaging: Technologies at the Interface of Genes, Brain, and Behavior

Neuroimaging Clinics of North America

Volumn 17, Issue 4, 2007, Pages 459-467

  Bigos, Kristin L ^a   Hariri, Ahmad R ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN PROTEIN; CATECHOL METHYLTRANSFERASE; GLUTAMATE RECEPTOR 3; PROTEIN KIBRA; SEROTONIN; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG;

ALLELE; ANTISOCIAL BEHAVIOR; ANXIETY DISORDER; BEHAVIOR CHANGE; BRAIN FUNCTION; DEPRESSION; DNA SEQUENCE; EPISODIC MEMORY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC POLYMORPHISM; HIPPOCAMPUS; HUMAN; MOOD DISORDER; NERVE CELL PLASTICITY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSESSIVE COMPULSIVE DISORDER; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

BEHAVIOR; BRAIN; BRAIN MAPPING; GENE EXPRESSION; HUMANS; POLYMORPHISM, GENETIC;

EID: 35649022177     PISSN: 10525149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nic.2007.09.005     Document Type: Review

References (54)

1. Plomin R., Owen M.J., and McGuffin P. The genetic basis of complex human behaviors. Science 264 5166 (1994) 1733-1739
2. Moldin S.O., and Gottesman II. At issue: genes, experience, and chance in schizophrenia-positioning for the 21st century. Schizophr Bull 23 4 (1997) 547-561
3. Hariri A.R., and Weinberger D.R. Imaging genomics. Br Med Bull 65 (2003) 259-270
4. Hariri A.R., Drabant E.M., and Weinberger D.R. Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol Psychiatry 59 10 (2006) 888-897
5. Brown S.M., Peet E., Manuck S.B., et al. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 10 9 (2005) 805
6. Devlin B., Roeder K., and Wasserman L. Genomic control, a new approach to genetic-based association studies. Theor Popul Biol 60 3 (2001) 155-166
7. Egan M.F., Kojima M., Callicott J.H., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 2 (2003) 257-269
8. Hariri A.R., Goldberg T.E., Mattay V.S., et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23 17 (2003) 6690-6694
9. Pezawas L., Verchinski B.A., Mattay V.S., et al. The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24 45 (2004) 10099-10102
10. Saunders A.M., Strittmatter W.J., Schmechel D., et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43 8 (1993) 1467-1472
11. Corder E.H., Saunders A.M., Strittmatter W.J., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261 5123 (1993) 921-923
12. Reiman E.M., Caselli R.J., Yun L.S., et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334 12 (1996) 752-758
13. Small G.W., Mazziotta J.C., Collins M.T., et al. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. JAMA 273 12 (1995) 942-947
14. Papassotiropoulos A., Stephan D.A., Huentelman M.J., et al. Common Kibra alleles are associated with human memory performance. Science 314 5798 (2006) 475-478
15. Sesack S.R., Hawrylak V.A., Matus C., et al. Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 18 7 (1998) 2697-2708
16. Weinshilboum R.M., Otterness D.M., and Szumlanski C.L. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol 39 (1999) 19-52
17. Goldman-Rakic P.S. Regional and cellular fractionation of working memory. Proc Natl Acad Sci USA 93 24 (1996) 13473-13480
18. Egan M.F., Goldberg T.E., Kolachana B.S., et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98 12 (2001) 6917-6922
19. Caspi A., Moffitt T.E., Cannon M., et al. Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry 57 10 (2005) 1117-1127
20. Egan M.F., Straub R.E., Goldberg T.E., et al. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci USA 101 34 (2004) 12604-12609
21. Callicott J.H., Straub R.E., Pezawas L., et al. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci USA 102 24 (2005) 8627-8632
22. Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44 3 (1998) 151-162
23. Manuck S.B., Flory J.D., McCaffery J.M., et al. Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 19 4 (1998) 287-299
24. Lesch K.P., Bengel D., Heils A., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 5292 (1996) 1527-1531
25. Heinz A., Jones D.W., Mazzanti C., et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 47 7 (2000) 643-649
26. Parsey R.V., Hastings R.S., Oquendo M.A., et al. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry 163 1 (2006) 48-51
27. Shioe K., Ichimiya T., Suhara T., et al. No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET. Synapse 48 4 (2003) 184-188
28. David S.P., Murthy N.V., Rabiner E.A., et al. A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci 25 10 (2005) 2586-2590
29. Lee M., Bailer U.F., Frank G.K., et al. Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women. Mol Psychiatry 10 8 (2005) 715-716
30. Fisher P.M., Meltzer C.C., Ziolko S.K., et al. Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity. Nat Neurosci 9 11 (2006) 1362-1363
31. Hariri A.R., and Holmes A. Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci 10 4 (2006) 182-191
32. Munafo M.R., Clark T., and Flint J. Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Mol Psychiatry 10 4 (2005) 415-419
33. Schinka J.A., Busch R.M., and Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 9 2 (2004) 197-202
34. Sen S., Burmeister M., and Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet 127B 1 (2004) 85-89
35. Garpenstrand H., Annas P., Ekblom J., et al. Human fear conditioning is related to dopaminergic and serotonergic biological markers. Behav Neurosci 115 2 (2001) 358-364
36. Caspi A., Sugden K., Moffitt T.E., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 5631 (2003) 386-389
37. Kendler K.S., Kuhn J.W., Vittum J., et al. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 62 5 (2005) 529-535
38. Hariri A.R., Mattay V.S., Tessitore A., et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 297 5580 (2002) 400-403
39. Canli T., Qiu M., Omura K., et al. Neural correlates of epigenesis. Proc Natl Acad Sci USA 103 43 (2006) 16033-16038
40. Brown S.M., and Hariri A.R. Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain, and behavior. Cogn Affect Behav Neurosci 6 1 (2006) 44-52
41. Canli T., Omura K., Haas B.W., et al. Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc Natl Acad Sci USA 102 34 (2005) 12224-12229
42. Hariri A.R., Drabant E.M., Munoz K.E., et al. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 62 2 (2005) 146-152
43. Heinz A., Smolka M., and Braus D. Amygdala activation, prefrontal metabolism and the serotonin transporter. Biol Psychiatry 55 8(S1) (2004) 43
44. Heinz A., Smolka M.N., Braus D.F., et al. Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation. Biol Psychiatry 61 8 (2007) 1011-1014
45. Domschke K., Braun M., Ohrmann P., et al. Association of the functional -1019C/G 5-HT1A polymorphism with prefrontal cortex and amygdala activation measured with 3 T fMRI in panic disorder. Int J Neuropsychopharmacol 9 3 (2006) 349-355
46. Furmark T., Tillfors M., Garpenstrand H., et al. Serotonin transporter polymorphism linked to amygdala excitability and symptom severity in patients with social phobia. Neurosci Lett 362 1 (2004) 1-4
47. Pezawas L., Meyer-Lindenberg A., Drabant E.M., et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8 6 (2005) 828-834
48. Meyer-Lindenberg A., Buckholtz J.W., Kolachana B., et al. Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci USA 103 16 (2006) 6269-6274
49. Maier S.F., and Watkins L.R. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev 29 4-5 (2005) 829-841
50. Canli T., Congdon E., Gutknecht L., et al. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm 112 11 (2005) 1479-1485
51. Pezawas L, A Meyer-Lindenberg, BS Kolachana, et al. Genetic epistasis at the level of neural circuitry. Nature Neuroscience, in press.
52. Luellen B.A., Bianco L.E., Schneider L.M., et al. Reduced brain-derived neurotrophic factor is associated with a loss of serotonergic innervation in the hippocampus of aging mice. Genes Brain Behav 6 5 (2007) 482-490
53. Ren-Patterson R.F., Cochran L.W., Holmes A., et al. Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies. Cell Mol Neurobiol 26 4-6 (2006) 753-778
54. Caspi A., and Moffitt T.E. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci 7 7 (2006) 583-590