메뉴 건너뛰기




Volumn 102, Issue 4, 2007, Pages 811-819

All in the family: Using inherited cancer syndromes to understand de-regulated cell signaling in brain tumors

Author keywords

Brain tumor signaling; Merlin; Neurofibromatosis 1; Neurofibromatosis 2; Neurofibromin; NF1; NF2; Schwannomin; TSC1 hamartin; TSC2 tuberin; Tuberous sclerosis complex

Indexed keywords

BRAIN TUMOR; CARCINOGENESIS; CELL DEATH; CELL GROWTH; CELL MOTILITY; CELL MOTION; CELL PROLIFERATION; HUMAN; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUBEROUS SCLEROSIS; TUMOR GROWTH;

EID: 35648959295     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21506     Document Type: Review
Times cited : (10)

References (50)
  • 1
    • 0036293742 scopus 로고    scopus 로고
    • Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
    • Bajenaru ML, Zhu Y, Hedrick NM, Donahoe J, Parada LF, Gutmann DH. 2002. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol 22:5100-5113.
    • (2002) Mol Cell Biol , vol.22 , pp. 5100-5113
    • Bajenaru, M.L.1    Zhu, Y.2    Hedrick, N.M.3    Donahoe, J.4    Parada, L.F.5    Gutmann, D.H.6
  • 6
    • 34447320760 scopus 로고    scopus 로고
    • Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth
    • Daginakatte GC, Gutmann DH. 2007. Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth. Hum Mol Genet 16:1098-1112.
    • (2007) Hum Mol Genet , vol.16 , pp. 1098-1112
    • Daginakatte, G.C.1    Gutmann, D.H.2
  • 7
    • 0141529951 scopus 로고    scopus 로고
    • The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes
    • Dasgupta B, Dugan LL, Gutmann DH. 2003. The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes. J Neurosci 23:8949-8954.
    • (2003) J Neurosci , vol.23 , pp. 8949-8954
    • Dasgupta, B.1    Dugan, L.L.2    Gutmann, D.H.3
  • 8
    • 16844375160 scopus 로고    scopus 로고
    • Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors
    • Dasgupta B, Yi Y, Chen DY, Weber JD, Gutmann DH. 2005. Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors. Cancer Res 65:2755-2760.
    • (2005) Cancer Res , vol.65 , pp. 2755-2760
    • Dasgupta, B.1    Yi, Y.2    Chen, D.Y.3    Weber, J.D.4    Gutmann, D.H.5
  • 9
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • European Chromosome 16 Tuberous Sclerosis Consortium
    • European Chromosome 16 Tuberous Sclerosis Consortium. 1993. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75:1305-1315.
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 12
    • 0033605484 scopus 로고    scopus 로고
    • Epidemiology of neurofibromatosis type 1
    • Friedman JM. 1999. Epidemiology of neurofibromatosis type 1. Am J Med Genet 89:1-6.
    • (1999) Am J Med Genet , vol.89 , pp. 1-6
    • Friedman, J.M.1
  • 18
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17:1829-1834.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 20
    • 33746722720 scopus 로고    scopus 로고
    • Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
    • Jin H, Sperka T, Herrlich P, Morrison H. 2006. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 442:576-579.
    • (2006) Nature , vol.442 , pp. 576-579
    • Jin, H.1    Sperka, T.2    Herrlich, P.3    Morrison, H.4
  • 23
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AG, Jr. 1971. Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823.
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 820-823
    • Knudson Jr., A.G.1
  • 24
    • 0033559663 scopus 로고    scopus 로고
    • Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
    • Kobayashi T, Minowa O, Kuno J, Mitani H, Hino O, Noda T. 1999. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 59:1206-1211.
    • (1999) Cancer Res , vol.59 , pp. 1206-1211
    • Kobayashi, T.1    Minowa, O.2    Kuno, J.3    Mitani, H.4    Hino, O.5    Noda, T.6
  • 25
    • 0035902509 scopus 로고    scopus 로고
    • A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
    • Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H, Kobayashi E, Noda T, Hino O. 2001. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci USA 98:8762-8767.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8762-8767
    • Kobayashi, T.1    Minowa, O.2    Sugitani, Y.3    Takai, S.4    Mitani, H.5    Kobayashi, E.6    Noda, T.7    Hino, O.8
  • 26
    • 27744588780 scopus 로고    scopus 로고
    • Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
    • Kwiatkowski DJ, Manning BD. 2005. Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways. Hum Mol Genet 14:251-258.
    • (2005) Hum Mol Genet , vol.14 , pp. 251-258
    • Kwiatkowski, D.J.1    Manning, B.D.2
  • 27
    • 0038077566 scopus 로고    scopus 로고
    • NF2 deficiency promotes tumori-genesis and metastasis by destabilizing adherens junctions
    • Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI. 2003. NF2 deficiency promotes tumori-genesis and metastasis by destabilizing adherens junctions. Genes Dev 17:1090-1100.
    • (2003) Genes Dev , vol.17 , pp. 1090-1100
    • Lallemand, D.1    Curto, M.2    Saotome, I.3    Giovannini, M.4    McClatchey, A.I.5
  • 28
    • 0031044804 scopus 로고    scopus 로고
    • Optic pathway gliomas in children with neurofibromatosis 1: Consensus statement from the NF1 Optic Pathway Glioma Task Force
    • Listernick R, Louis DN, Packer RJ, Gutmann DH. 1997. Optic pathway gliomas in children with neurofibromatosis 1: Consensus statement from the NF1 Optic Pathway Glioma Task Force. Ann Neurol 41:143-149.
    • (1997) Ann Neurol , vol.41 , pp. 143-149
    • Listernick, R.1    Louis, D.N.2    Packer, R.J.3    Gutmann, D.H.4
  • 30
    • 0030924657 scopus 로고    scopus 로고
    • The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation
    • McClatchey AI, Saotome I, Ramesh V, Gusella JF, Jacks T. 1997. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev 11:1253-1265.
    • (1997) Genes Dev , vol.11 , pp. 1253-1265
    • McClatchey, A.I.1    Saotome, I.2    Ramesh, V.3    Gusella, J.F.4    Jacks, T.5
  • 32
    • 33744722469 scopus 로고    scopus 로고
    • Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells
    • Munchhof AM, Li F, White HA, Mead LE, Krier TR, Fenoglio A, Li X, Yuan J, Yang FC, Ingram DA. 2006. Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Hum Mol Genet 15: 1858-1869.
    • (2006) Hum Mol Genet , vol.15 , pp. 1858-1869
    • Munchhof, A.M.1    Li, F.2    White, H.A.3    Mead, L.E.4    Krier, T.R.5    Fenoglio, A.6    Li, X.7    Yuan, J.8    Yang, F.C.9    Ingram, D.A.10
  • 33
    • 0027937181 scopus 로고
    • Neurofibromatosis 2 (NF2): Clinical characteristics of 63 affected individuals and clinical evidence for heterogeneity
    • Parry DM, Eldridge R, Kaiser-Kupfer MI, Bouzas EA, Pikus A, Patronas N. 1994. Neurofibromatosis 2 (NF2): Clinical characteristics of 63 affected individuals and clinical evidence for heterogeneity. Am J Med Genet 52:450-461.
    • (1994) Am J Med Genet , vol.52 , pp. 450-461
    • Parry, D.M.1    Eldridge, R.2    Kaiser-Kupfer, M.I.3    Bouzas, E.A.4    Pikus, A.5    Patronas, N.6
  • 34
    • 0035805162 scopus 로고    scopus 로고
    • Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
    • Potter CJ, Huang H, Xu T. 2001. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105:357-368.
    • (2001) Cell , vol.105 , pp. 357-368
    • Potter, C.J.1    Huang, H.2    Xu, T.3
  • 35
    • 9144234897 scopus 로고    scopus 로고
    • Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression
    • Rong R, Surace EI, Haipek CA, Gutmann DH, Ye K. 2004. Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression. Oncogene 23:8447-8454.
    • (2004) Oncogene , vol.23 , pp. 8447-8454
    • Rong, R.1    Surace, E.I.2    Haipek, C.A.3    Gutmann, D.H.4    Ye, K.5
  • 37
    • 0036897927 scopus 로고    scopus 로고
    • Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling
    • Scoles DR, Nguyen VD, Qin Y, Sun CX, Morrison H, Gutmann DH, Pulst SM. 2002. Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Hum Mol Genet 11:3179-3189.
    • (2002) Hum Mol Genet , vol.11 , pp. 3179-3189
    • Scoles, D.R.1    Nguyen, V.D.2    Qin, Y.3    Sun, C.X.4    Morrison, H.5    Gutmann, D.H.6    Pulst, S.M.7
  • 40
    • 0036860545 scopus 로고    scopus 로고
    • Protein 4.1 tumor suppressors: Getting a FERM grip on growth regulation
    • Sun CX, Robb VA, Gutmann DH. 2002. Protein 4.1 tumor suppressors: Getting a FERM grip on growth regulation. J Cell Sci 115:3991-4000.
    • (2002) J Cell Sci , vol.115 , pp. 3991-4000
    • Sun, C.X.1    Robb, V.A.2    Gutmann, D.H.3
  • 41
    • 0035805180 scopus 로고    scopus 로고
    • The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
    • Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK. 2001. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105:345-355.
    • (2001) Cell , vol.105 , pp. 345-355
    • Tapon, N.1    Ito, N.2    Dickson, B.J.3    Treisman, J.E.4    Hariharan, I.K.5
  • 42
    • 0141733228 scopus 로고    scopus 로고
    • Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
    • Tee AR, Anjum R, Blenis J. 2003. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J Biol Chem 278:37288-37296.
    • (2003) J Biol Chem , vol.278 , pp. 37288-37296
    • Tee, A.R.1    Anjum, R.2    Blenis, J.3
  • 43
    • 0036159132 scopus 로고    scopus 로고
    • Neurofibromin regulates G protein-stimulated adenylyl cyclase activity
    • Tong J, Hannan F, Zhu Y, Bernards A, Zhong Y. 2002. Neurofibromin regulates G protein-stimulated adenylyl cyclase activity. Nat Neurosci 5:95-96.
    • (2002) Nat Neurosci , vol.5 , pp. 95-96
    • Tong, J.1    Hannan, F.2    Zhu, Y.3    Bernards, A.4    Zhong, Y.5
  • 49
    • 0025244911 scopus 로고
    • The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae
    • Xu GF, Lin B, Tanaka K, Dunn D, Wood D, Gesteland R, White R, Weiss R, Tamanoi F. 1990. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63:835-841.
    • (1990) Cell , vol.63 , pp. 835-841
    • Xu, G.F.1    Lin, B.2    Tanaka, K.3    Dunn, D.4    Wood, D.5    Gesteland, R.6    White, R.7    Weiss, R.8    Tamanoi, F.9
  • 50
    • 0037012848 scopus 로고    scopus 로고
    • Neurofibromas in N F1:Schwann cell origin and role of tumor environment
    • Zhu Y, Ghosh P, Charnay P, Burns DK, Parada LF. 2002. Neurofibromas in N F1:Schwann cell origin and role of tumor environment. Science 296:920-922.
    • (2002) Science , vol.296 , pp. 920-922
    • Zhu, Y.1    Ghosh, P.2    Charnay, P.3    Burns, D.K.4    Parada, L.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.