Synthesis and evaluation of the antioxidant and antiinflammatory activities of some benzo[l]khellactone derivatives and analogues

European Journal of Medicinal Chemistry

Volumn 39, Issue 4, 2004, Pages 323-332

  Nicolaides, Demetrios N ^a   Gautam, Daman R ^a   Litinas, Konstantinos E ^a   Hadjipavlou Litina, Dimitra J ^a   Fylaktakidou, Konstantina C ^b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Antiinflammatory activity; Antioxidant activity; Benzo f seselin; Benzo l khellactones; Wittig reaction

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2 DIMETHYL 2H,6H BENZO[F]PYRANO[2,3 H]CHROMEN 6 ONE; 3 HYDROXY 2,2 DIMETHYL 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMEN 6 ONE; 3 HYDROXY BETA LAPACHONE; BENZENE DERIVATIVE; CARRAGEENAN; COUMARIN DERIVATIVE; DIMETHYL SULFOXIDE; ETHYL 2,2 DIMETHYL 3 [(3 METHYL 2 BUTENOYL)OXY] 6 OXO 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 2,2 DIMETHYL 3,6 DIOXO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 2,2 DIMETHYL 6 OXO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 2,2 DIMETHYL 6 OXO 3 [[(4,7,7 TRIMETHYL 3 OXO 2 OXABICYCLO[2.2.1]HEPT 1 YL)CARBONYL]OXY] 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 2,2 DIMETHYL 6 OXO 3,4 BIS[[(4,7,7 TRIMETHYL 3 OXO 2 OXABICYCLO[2.2.1]HEPT 1 YL)CARBONYL]OXY] 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 3 HYDROXY 2,2 DIMETHYL 6 OXO 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 3 HYDROXY 4 [[(4,7,7 TRIMETHYL 3 OXO 2 OXABICYCLO[2.2.1]HEPT 1 YL)CARBONYL]OXY] 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 3,4 DIHYDROXY 2,2 DIMETHYL 6 OXO 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 3,4 DIHYDROXY 2,2 DIMETHYL 6 OXO 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 9 CARBOXYLATE; ETHYL 4 [(3 CHLOROBENZOYL)OXY] 2,2 DIMETHYL 6 OXO 3 [[(4,7,7 TRIMETHYL 3 OXO 2 OXABICYCLO[2.2.1]HEPT 1 YL)CARBONYL]OXY] 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; ETHYL 4 [(3 CHLOROBENZOYL)OXY] 3 HYDROXY 2,2 DIMETHYL 6 OXO 3,4 DIHYDRO 2H,6H BENZO[F]PYRANO[2,3 H]CHROMENE 8 CARBOXYLATE; HALIDE; HYDROXYL GROUP; KHELLACTONE; LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CIS ISOMER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; EXPERIMENTAL TEST; NONHUMAN; PAW EDEMA; RAT; SOYBEAN; TRANS ISOMER;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CARRAGEENAN; EDEMA; LACTONES; MODELS, CHEMICAL; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1842505240     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.01.003     Document Type: Article

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