Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma

Molecular Immunology

Volumn 45, Issue 4, 2008, Pages 898-909

  Ho, Tsung Chuan ^a   Yang, Yuh Cheng ^a,b,c   Chen, Show Li ^d   Kuo, Ping Chang ^d   Sytwu, Huey Kang ^e   Cheng, Huey Chuan ^a   Tsao, Yeou Ping ^a,e  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Apoptosis; Macrophages; Necrosis; PEDF; PPAR

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CYTOCHROME C; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIGMENT EPITHELIUM DERIVED FACTOR; PROCASPASE 3; PROCASPASE 9; PROTEIN P53; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; MACROPHAGE; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION;

ANILIDES; APOPTOSIS; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; ENZYME ACTIVATION; EYE PROTEINS; HUMANS; MACROPHAGES; NECROSIS; NERVE GROWTH FACTORS; PPAR GAMMA; SERPINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 35549005947     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.08.004     Document Type: Article

References (48)

1. Abe R., Shimizu T., Yamagishi S., Shibaki A., Amano S., Inagaki Y., Watanabe H., Sugawara H., Nakamura H., Takeuchi M., Imaizumi T., and Shimizu H. Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo. Am. J. Pathol. 164 (2004) 1225-1232
2. Auwerx J. The human leukemia cell line, THP-1: a multifaceted model for the study of monocyte-macrophage differentiation. Experientia 47 (1991) 22-31
3. Baba H., Yonemitsu Y., Nakano T., Onimaru M., Miyazaki M., Ikeda Y., Sumiyoshi S., Ueda Y., Hasegawa M., Yoshino I., Maehara Y., and Sueishi K. Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 1938-1944
4. Barlic J., Zhang Y., Foley J.F., and Murphy P.M. Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathway. Circulation 114 (2006) 807-819
5. Barnstable C.J., and Tombran-Tink J. Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Prog. Retin. Eye Res. 23 (2004) 561-577
6. Barreiro R., Schadlu R., Herndon J., Kaplan H.J., and Ferguson T.A. The role of Fas-FasL in the development and treatment of ischemic retinopathy. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1282-1286
7. Bodles A.M., Varma V., Yao-Borengasser A., Phanavanh B., Peterson C.A., McGehee Jr. R.E., Rasouli N., Wabitsch M., and Kern P.A. Pioglitazone induces apoptosis of macrophages in human adipose tissue. J. Lipid Res. 47 (2006) 2080-2088
8. Bonofiglio D., Aquila S., Catalano S., Gabriele S., Belmonte M., Middea E., Qi H., Morelli C., Gentile M., Maggiolini M., and Ando S. Peroxisome proliferator-activated receptor (PPAR) gamma activates p53 gene promoter binding to the NFkB sequence in human MCF7 breast cancer cells. Mol. Endocrinol. 20 (2006) 3083-3092
9. Chawla A., Boisvert W.A., Lee C.H., Laffitte B.A., Barak Y., Joseph S.B., Liao D., Nagy L., Edwards P.A., Curtiss L.K., Evans R.M., and Tontonoz P. PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol. Cell 7 (2001) 161-171
10. Chen Y.C., Wang S.Y., and King C.C. Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. J. Virol. 73 (1999) 2650-2657
11. Chen L., Zhang S.S., Barnstable C.J., and Tombran-Tink J. PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases. Biochem. Biophys. Res. Commun. 348 (2006) 1288-1295
12. Chinetti G., Griglio S., Antonucci M., Torra I.P., Delerive P., Majd Z., Fruchart J.C., Chapman J., Najib J., and Staels B. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J. Biol. Chem. 273 (1998) 25573-25580
13. Chinetti G., Lestavel S., Bocher V., Remaley A.T., Neve B., Torra I.P., Teissier E., Minnich A., Jaye M., Duverger N., Brewer H.B., Fruchart J.C., Clavey V., and Staels B. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. 7 (2001) 53-58
14. Cipollone F., Prontera C., Pini B., Marini M., Fazia M., De Cesare D., Iezzi A., Ucchino S., Boccoli G., Saba V., Chiarelli F., Cuccurullo F., and Mezzetti A. Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability. Circulation 104 (2001) 921-927
15. Dawson D.W., Volpert O.V., Gillis P., Crawford S.E., Xu H., Benedict W., and Bouck N.P. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285 (1999) 245-248
16. de Winther M.P., Kanters E., Kraal G., and Hofker M.H. Nuclear factor kappa B signaling in atherogenesis. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 904-914
17. Doll J.A., Stellmach V.M., Bouck N.P., Bergh A.R., Lee C., Abramson L.P., Cornwell M.L., Pins M.R., Borensztajn J., and Crawford S.E. Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat. Med. 9 (2003) 774-780
18. Filleur S., Volz K., Nelius T., Mirochnik Y., Huang H., Zaichuk T.A., Aymerich M.S., Becerra S.P., Yap R., Veliceasa D., Shroff E.H., and Volpert O.V. Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. Cancer Res. 65 (2005) 5144-5152
19. Fu M., Zhang J., Lin Y., Zhu X., Ehrengruber M.U., and Chen Y.E. Early growth response factor-1 is a critical transcriptional mediator of peroxisome proliferator-activated receptor-gamma 1 gene expression in human aortic smooth muscle cells. J. Biol. Chem. 277 (2002) 26808-26814
20. Geng Y.J., and Libby P. Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme. Am. J. Pathol. 147 (1995) 251-266
21. Gilroy D.W., Colville-Nash P.R., McMaster S., Sawatzky D.A., Willoughby D.A., and Lawrence T. Inducible cyclooxygenase-derived 15-deoxy (Delta) 12-14 PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis. FASEB J. 17 (2003) 2269-2271
22. Gurnell M., Savage D.B., Chatterjee V.K., and O'Rahilly S. The metabolic syndrome: peroxisome proliferator-activated receptor γ and its therapeutic modulation. J. Clin. Endocrinol. Metab. 88 (2003) 2412-2421
23. Jiang C., Ting A.T., and Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391 (1998) 82-86
24. Kast-Woelbern H.R., Dana S.L., Cesario R.M., Sun L., De Grandpre L.Y., Brooks M.E., Osburn D.L., Reifel-Miller A., Klausing K., and Leibowitz M.D. Rosiglitazone induction of INSIG-1 in white adipose tissue reveals a novel interplay of PPARg and SREBP in the regulation of adipogenesis. J. Biol. Chem. 279 (2004) 23908-23915
25. Kim J.S., He L., and Lemasters J.J. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem. Biophys. Res. Commun. 304 (2003) 463-470
26. Law R.E., Goetze S., Xi X.P., Jackson S., Kawano Y., Demer L., Fishbein M.C., Meehan W.P., and Hsueh W.A. Expression and function of PPAR gamma in rat and human vascular smooth muscle cells. Circulation 101 (2000) 1311-1318
27. Li F., Srinivasan A., Wang Y., Armstrong R.C., Tomaselli K.J., and Fritz L.C. Cell specific induction of apoptosis by microinjection of cytochrome c. J. Biol. Chem. 272 (1997) 30299-30305
28. Liu Y., Zhu Y., Rannou F., Lee T.S., Formentin K., Zeng L., Yuan X., Wang N., Chien S., Forman B.M., and Shyy J.Y. Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells. Circulation 110 (2004) 1128-1133
29. Mangelsdorf D.J., and Evans R.M. The RXR heterodimers and orphan receptors. Cell 83 (1995) 841-850
30. Nolte R.T., Wisely G.B., Westin S., Cobb J.E., Lambert M.H., Kurokawa R., Rosenfeld M.G., Willson T.M., Glass C.K., and Milburn M.V. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ. Nature 10 (1998) 137-143
31. Notari L., Baladron V., Aroca-Aguilar J.D., Balko N., Heredia R., Meyer C., Notario P.M., Saravanamuthu S., Nueda M.L., Sanchez-Sanchez F., Escribano J., Laborda J., and Becerra S.P. Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J. Biol. Chem. 281 (2006) 38022-38037
32. Petersen S.V., Valnickova Z., and Enghild J.J. Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization. Biochem. J. 374 (2003) 199-206
33. Polyak K., Xia Y., Zweier J.L., Kinzler K.W., and Vogelstein B. A model for p53-induced apoptosis. Nature 389 (1997) 300-305
34. Ricote M., Li A.C., Willson T.M., Kelly C.J., and Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391 (1998) 79-82
35. Ricote M., Huang J., Fajas L., Li A., Welch J., Najib J., Witztum J.L., Auwerx J., Palinski W., and Glass C.K. Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 7614-7619
36. Rizzo G., and Fiorucci S. PPARs and other nuclear receptors in inflammation. Curr. Opin. Pharmacol. 6 (2006) 421-427
37. Rowe A.H., Argmann C.A., Edwards J.Y., Sawyez C.G., Morand O.H., Hegele R.A., and Huff M.W. Enhanced synthesis of the oxysterol 24(S), 25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation. Circ. Res. 93 (2003) 717-725
38. Stellmach V., Crawford S.E., Zhou W., and Bouck N. Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 2593-2597
39. Tombran-Tink J., and Barnstable C.J. Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor. Trends Mol. Med. 9 (2003) 244-250
40. Tombran-Tink J., Mazuruk K., Rodriguez I.R., Chung D., Linker T., Englander E., and Chader G.J. Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin. Mol. Vis. 4 (1996) 11
41. Tsao Y.P., Ho T.C., Chen S.L., and Cheng H.C. Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells. Life Sci. 79 (2006) 545-550
42. Urade Y., Ujihara M., Horiguchi Y., Ikai K., and Hayaishi O. The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. J. Immunol. 143 (1989) 2982-2989
43. Uriarte S.M., Joshi-Barve S., Song Z., Sahoo R., Gobejishvili L., Jala V.R., Haribabu B., McClain C., and Barve S. Akt inhibition upregulates FasL, downregulates c-FLIPs and induces caspase-8-dependent cell death in Jurkat T lymphocytes. Cell Death Differ. 12 (2005) 233-242
44. Volpert O.V., Zaichuk T., Zhou W., Reiher F., Ferguson T.A., Stuart P.M., Amin M., and Bouck N.P. Inducer-stimulated Fas targets-activated endothelium for destruction by anti-angiogenic thombospondin-1 and pigment epithelium-derived factor. Nat. Med. 8 (2002) 349-357
45. Warny M., and Kelly C.P. Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases. Am. J. Physiol. 276 (1999) C717-C724
46. Worley J.R., Baugh M.D., Hughes D.A., Edwards D.R., Hogan A., Sampson M.J., and Gavrilovic J. Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. J. Biol. Chem. 278 (2003) 51340-51346
47. Zamiri P., Masli S., Streilein J.W., and Taylor A.W. Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation. Invest. Ophthalmol. Vis. Sci. 47 (2006) 3912-3918
48. Zhang S.X., Wang J.J., Gao G., Shao C., Mott R., and Ma J.X. Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. FASEB J. 20 (2006) 323-335