Spinal cord compression

European Journal of Cancer, Supplement

Volumn 5, Issue 5, 2007, Pages 359-370

  Rades, Dirk ^a   Schild, Steven E ^b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CORTICOSTEROID; DEXAMETHASONE; IBANDRONIC ACID; PAMIDRONIC ACID; PARATHYROID HORMONE; ZOLEDRONIC ACID;

ARTICLE; BLEEDING; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; DRUG MEGADOSE; GERM CELL TUMOR; HEMATOLOGIC MALIGNANCY; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LOADING DRUG DOSE; LONG TERM CARE; LOW DRUG DOSE; MALIGNANT NEOPLASTIC DISEASE; PERFORATION; PRIORITY JOURNAL; PROGNOSIS; RADIOSURGERY; SCORING SYSTEM; SHORT COURSE THERAPY; SINGLE DRUG DOSE; SPINAL CORD COMPRESSION; SPINAL CORD DECOMPRESSION; TREATMENT OUTCOME; ULCER;

EID: 35549002765     PISSN: 13596349     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6349(07)70064-2     Document Type: Article

References (83)

1. Prasad D., and Schiff D. Malignant spinal-cord compression. Lancet, Oncol 6 (2005) 15-24
2. Spiller W. Rapidly progressive paralysis associated with carcinoma. AMA Arch Neurol Psychiatry 13 (1925) 471-477
3. Harrington K. Metastatic tumors of the spine: diagnosis and treatment. J Am Acad Orthop Surg 1 (1993) 76-86
4. Bohm P., and Huber J. The surgical treatment of bony metastases of the spine and limbs. J Bone Joint Surg Br 84 (2002) 521-529
5. Wong D., Fornasier V., and MacNab I. Spinal metastases: the obvious, the occult, and the impostors. Spine 15 (1990) 1-4
6. Pigott K., Baddeley H., and Maher E. Pattern of disease in spinal cord compression on MRI scan and implications for treatment. Clin Oncol 6 (1994) 7-10
7. Heldmann U., Myschetzky P., and Thomsen H. Frequency of unexpected multifocal metastasis in patients with acute spinal cord compression. Evaluation of low-field MR imaging in cancer patients. Acta Radiol 38 (1997) 372-375
8. Cook A., Lau T., Tomlinson M., Vaidya M., Wakeley C., and Goddard P. Magnetic resonance imaging of the whole spine in suspected malignant spinal cord compression: impact on management. Clin Oncol 10 (1998) 39-43
9. Schiff D., O'Neill B., Wang C., and O'Fallon J. Neuroimaging and treatment implications of patients with multiple epidural spinal metastases. Cancer 83 (1998) 1593-1601
10. Loblaw D., Laperriere N., and Mackillop W. A population-based study of malignant spinal cord compression in Ontario. Clin Oncol 15 (2003) 211-217
11. Bach F., Larsen B., Rohde K., et al. Metastatic spinal cord compression. Occurrence, symptoms, clinical presentations, and prognosis in 398 patients with spinal cord compression. Acta Neurochir 107 (1990) 37-43
12. Rades D., Fehlauer F., Schulte R., et al. Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression. J Clin Oncol 24 (2006) 3388-3393
13. Arguello F., Baggs R., Duerst R., Johnstone L., McQueen K., and Frantz C. Pathogenesis of vertebral metastasis and epidural spinal cord compression. Cancer 65 (1990) 98-106
14. Ushio Y., Posner R., Posner J., and Shapiro W. Experimental spinal cord compression by epidural neoplasms. Neurology 27 (1977) 422-429
15. Kato A., Ushio Y., Hayakawa T., Yamada K., Ikeda H., and Mogami H. Circulatory disturbance of the spinal cord with epidural neoplasms in rats. J Neurosurg 63 (1985) 260-265
16. Manabe S., Tanaka H., Hogo Y., Park P., Ohno T., and Tateishi A. Experimental analysis of the spinal cord compressed by spinal metastasis. Spine 14 (1989) 1308-1315
17. Tarlov I., Klinger H., and Vitale S. Spinal cord compression studies. I. Experimental techniques to produce acute and gradual compression. AMA Arch Neurol Psychiatry 70 (1953) 813-819
18. Tarlov I., and Klinger H. Spinal cord compression studies. II. Time limits for recovery after acute compression in dogs. AMA Arch Neurol Psychiatry 71 (1954) 271-290
19. Rades D., Heidenreich F., and Karstens J. Final results of a prospective study of the prognostic value of the time to develop motor deficits before irradiation in metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 53 (2002) 975-979
20. Li K., and Poon P. Sensitivity and specificity of MRI in detecting malignant spinal cord compression and in distinguishing malignant from benign compression fractures of vertebrae. Magn Reson Imaging 6 (1988) 547-556
21. Colletti P., Siegel H., Woo M., Young H., and Terk M. The impact on treatment planning of MRI of the spine in patients suspected of vertebral metastasis: an efficacy study. Comput Med Imaging Graph 20 (1996) 159-162
22. Rades D., Bremer M., Goehde S., Joergensen M., and Karstens J. Spondylodiscitis in patients with spinal cord compression: a possible pitfall in radiation oncology. Radiother Oncol 59 (2001) 307-309
23. Gilbert R., Kim J., and Posner R. Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 3 (1978) 40-51
24. Kovner F., Spigel S., Rider I., et al. Radiation therapy of metastatic spinal cord compression. Multidisciplinary team diagnosis and treatment. J Neurooncol 42 (1999) 85-92
25. Helweg-Larsen S., Sørensen P., and Kreiner S. Prognostic factors in metastatic spinal cord compression: a prospective study using multivariate analysis of variables influencing survival and gait function in 153 patients. Int J Radiat Oncol Biol Phys 46 (2000) 1163-1169
26. Maranzano E., and Latini P. Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial. Int J Radiat Oncol Biol Phys 32 (1995) 959-967
27. Husband D. Malignant spinal cord compression: prospective study of delays in referral and treatment. BMJ 317 (1998) 18-21
28. Gilbert H., Apuzzo M., Marshall L., et al. Neoplastic epidural spinal cord compression. A current perspective. JAMA 240 (1978) 2771-2773
29. Tomita T., Galicich J., and Sundaresan N. Radiation therapy for spinal epidural metastases with complete block. Acta Radiol Oncol 22 (1983) 135-143
30. Baskin D. Spinal cord injury. In: Ewans R. (Ed). Neurology and trauma (1996), Saunders, Philadelphia 276-299
31. Patchell R., Tibbs P., Regine W., et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366 (2005) 643-648
32. Rades D., Stalpers L., Veninga T., et al. Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression. J Clin Oncol 23 (2005) 3366-3375
33. Kim R., Smith J., Spencer S., Meredith R., and Salter M. Malignant epidural spinal cord compression associated with a paravertebral mass: its radiotherapeutic outcome on radiosensitivity. Int J Radiat Oncol Biol Phys 27 (1993) 1079-1083
34. Rades D., Fehlauer F., Stalpers L., et al. A prospective evaluation of two radiation schedules with 10 versus 20 fractions for the treatment of metastatic spinal cord compression: final results of a multi-center study. Cancer 101 (2004) 2687-2692
35. Maranzano E., Bellavita R., Rossi R., et al. Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial. J Clin Oncol 23 (2005) 3358-3365
36. Koswig S., and Budach V. Remineralization and pain relief in bone metastases after after different radiotherapy fractions (10 times 3 Gy vs. 1 time 8 Gy). A prospective study. Strahlenther Onkol 175 (1999) 500-508
37. Steenland E., Leer J., van Houwelingen H., et al. The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study. Radiother Oncol 52 (1999) 101-109
38. Sørensen P., Børgesen S., Rohde K., et al. Metastatic epidural spinal cord compression. Cancer 65 (1990) 1502-1509
39. Helweg-Larsen, Hansen S., and Sørensen P. Second occurrence of symptomatic metastatic spinal cord compression and findings of multiple spinal epidural metastases. Int J Radiat Oncol Biol Phys 33 (1995) 595-598
40. Maranzano E., Latini P., Perrucci E., Beneventi S., Lupattelli M., and Corgna E. Short-course radiotherapy (8 Gy ×2) in metastatic spinal cord compression: an effective and feasible treatment. Int J Radiat Oncol Biol Phys 38 (1997) 1037-1044
41. Rades D., Heidenreich F., Bremer M., and Karstens J. Time of developing motor deficits before radiotherapy as a new and relevant prognostic factor in metastatic spinal cord compression: final results of a retrospective analysis. Eur Neurol 45 (2001) 266-269
42. Hoskin P., Grover A., and Bhana R. Metastatic spinal cord compression: radiotherapy outcome and dose fractionation. Radiother Oncol 68 (2003) 175-180
43. Nielsen O., Bentzen S., Sandberg E., et al. Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases. Radiother Oncol 47 (1998) 233-240
44. Bone Pain Trial Working Party. 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain (randomised comparison with a multifraction schedule over 12 months of patient follow-up). Radiother Oncol 52 (1999) 111-121
45. Sze W., Shelley M., Held I., Wilt T., and Mason M. Palliation of metastatic bone pain (Single fraction versus multifraction radiotherapy-a systematic review of randomised trials). Clin, Oncol 15 (2003) 345-352
46. Klimo Jr. P., Kestle J., and Schmidt M. Treatment of metastatic spinal epidural disease: a review of the literature. Neurosurg, Focus 15 (2003) 1-9
47. Maranzano E., Latini P., Beneventi S., et al. Comparison of two different radiotherapy schedules for spinal cord compression in prostate cancer. Tumori 84 (1998) 472-477
48. Rades D., Karstens J., and Alberti W. The role of radiotherapy in the treatment of motor dysfunction due to metastatic spinal cord compression: a comparison of three different fractionation schedules. Int J Radiat Oncol Biol Phys 54 (2002) 1160-1164
49. Rades D., Stalpers L., Hulshof M., et al. Comparison of 1×8 Gy and 10×3 Gy for functional outcome in patients with metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 62 (2005) 514-518
50. Rades D., Veninga T., Stalpers L., et al. Prognostic factors predicting functional outcome, recurrence-free survival, and overall survival after radiotherapy of metastatic spinal cord compression in breast cancer patients. Int J Radiat Oncol Biol, Phys 64 (2006) 182-188
51. Rades D., Stalpers L., Veninga T., et al. Evaluation of functional outcome and local control after radiotherapy for metastatic spinal cord compression in prostate cancer patients. J Urol 175 (2006) 552-556
52. Rades D., Stalpers L., Schulte R., et al. Defining the appropriate radiotherapy regimen for metastatic spinal cord compression (MSCC) in non-small cell lung cancer (NSCLC) patients. Eur, J Cancer 42 (2006) 1052-1056
53. Rades D., Hoskin P., Stalpers L., et al. Short-course radiotherapy is not optimal for spinal cord compression due to myeloma. Int J Radiat Oncol Biol Phys 64 (2006) 1452-1457
54. Rades D., Fehlauer F., Veninga T., et al. Functional outcome and survival after radiotherapy of metastatic spinal cord compression in patients with cancer of unknown primary. Int J Radiat Oncol, Biol Phys 67 (2007) 532-537
55. Rades D., Walz J., Stalpers L., et al. Short-course radiotherapy (RT) for metastatic spinal cord compression (MSCC) due to renal cell carcinoma: results of a retrospective multi-center study. Eur, Urol 49 (2006) 846-852
56. Rades D., Dahm-Daphi J., Rudat V., et al. Is short-course radiotherapy with high doses per fraction the appropriate regimen for metastatic spinal cord compression in colorectal cancer patients?. Strahlenther Onkol 182 (2006) 708-712
57. Kaminski H., Diwan, and Ruff R. Second occurrence of spinal epidural metastases. Neurology 41 (1991) 744-746
58. Joiner M., and Van der Kogel A. The linear-quadratic approach to fractionation and calculation of isoeffect relationships. In: Steel G. (Ed). Basic clinical radiobiology (1997), Oxford University Press, New York 106-112
59. Rades D., Stalpers L., Veninga T., and Hoskin P. Spinal reirradiation after short-course RT for metastatic spinal cord compression. Int, J Radiat Oncol Biol Phys 63 (2005) 872-875
60. Nieder C., Grosu A., Andratschke N., and Molls M. Update of human spinal cord reirradiation tolerance based on additional data from 38 patients. Int J Radiat Oncol Biol Phys 66 (2006) 1446-1449
61. Ryu S., Yin F., Rock J., et al. Image-guided and intensity- modulated radiosurgery for patients with spinal metastasis. Cancer 97 (2002) 2013-2018
62. Milker-Zabel S., Zabel A., Thilmann C., Schlegel W., Wannenmacher M., and Debus J. Clinical results of retreatment of vertebral bone metastases by stereotactic conformal radiotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 55 (2003) 162-167
63. Brown P., Stafford S., Schild S., Martenson J., and Schiff D. Metastatic spinal cord compression in patients with colorectal cancer. J Neuro-Oncol 44 (1999) 175-180
64. Rades D., Dunst J., and Schild S. The first score predicting overall survival in patients with metastatic spinal cord compression. Cancer (2007) in press.
65. Findley G. The role of vertebral body collapse in the management of malignant spinal cord compression. J Neurol Neurosurg Psychiatry 50 (1987) 151-154
66. Klimo Jr. P., Dailey A., and Fessler R. Posterior surgical approaches and outcomes in metastatic spine-disease. Neurosurg Clin N Am 15 (2004) 425-435
67. Yen D., Kuriachan V., Yach J., and Howard A. Long-term outcome of anterior decompression and spinal fixation after placement of the Welesley Wedge for thoracic and lumbar spinal metastasis. J Neurosurg 96 suppl 1 (2002) 6-9
68. Klimo Jr. P., Thompson C., Kestle J., and Schmidt M. A meta- analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro-Oncol 7 (2004) 64-76
69. Kunkler I. Surgical resection in metastatic spinal cord compression. Lancet 367 (2006) 109
70. Knisely J., and Strugar J. Can decompressive surgery improve outcome in patients with metastatic epidural spinal-cord compression?. Nat Clin Pract Oncol 3 (2006) 14-15
71. Young R., Post E., and King G. Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. J Neurosurg 53 (1980) 741-748
72. Sørensen P., Borgesen S., Rohde K., et al. Metastatic epidural spinal cord compression: results of treatment and survival. Cancer 65 (1990) 1502-1508
73. Amar A., and Levy M. Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury. Neurosurgery 44 (1999) 1027-1040
74. Loblaw D., and Laperriere N. Emergency treatment of malignant extradural spinal cord compression: an evidence-based guideline. J Clin Oncol 16 (1998) 1613-1624
75. Sørensen P., Helweg-Larsen S., Mouridsen H., and Hansen H. Effect of high-dose dexamethasone in carcinomatous metastatic spinal cord compression treated with radiotherapy: a randomized trial. Eur J Cancer 30A (1994) 22-27
76. Heimdal K., Hirschberg H., Slettebo H., Watne K., and Nome O. High incidence of serious side effects of high-dose dexamethasone treatment in patients with epidural spinal cord compression. J Neurooncol 12 (1992) 141-144
77. Saad F., Gleason D., Murrey R., et al. A randomized, placebo- controlled trial of zoledronic acid in patients with hormone- refractory metastatic prostate carcinoma. J Natl Cancer Inst 94 (2002) 1458-1468
78. Rosen L., Gordon D., Tchekmedyian S., et al. Zoledronic acid versus placebo in the treatment of skeletal metastases in patients with lung cancer and other solid tumors: a phase II, double- blind, randomized trial - The Zoledronic Acid Lung Cancer and Other Solid Tumors Study Group. Rosen. J Clin Oncol 21 (2003) 3150-3157
79. Rosen L., Gordon D., Dugan W., et al. Zoledronic acid is superior to pamidronate for the treatment of bone metastases in breast carcinoma patients with at least one osteolytic lesion. Cancer 100 (2004) 36-43
80. Aviles A., Fernandez R., Gonzalez J., et al. Spinal cord compression as a primary manifestation of aggressive malignant lymphomas: long-term analysis of treatments with radiotherapy, chemotherapy or combined therapy. Leuk Lymphoma 43 (2002) 355-359
81. Wallington M., Mendis S., Premawardhana U., Sanders P., and Shahsavar-Haghighi K. Local control and survival in spinal cord compression from lymphoma and myeloma. Radiother Oncol 42 (1997) 43-47
82. Higgins S., and Peschel R. Hodgkin's disease with spinal cord compression. A case report and a review of the literature. Cancer 75 (1995) 94-98
83. Rades D., Veninga T., Stalpers L., et al. Excellent outcome after radiotherapy alone for metastatic spinal cord compression (MSCC) in patients with oligometastases. J Clin Oncol 25 (2007) 50-56