Short-Course Radiotherapy (RT) for Metastatic Spinal Cord Compression (MSCC) Due to Renal Cell Carcinoma: Results of a Retrospective Multi-Center Study

European Urology

Volumn 49, Issue 5, 2006, Pages 846-852

  Rades, Dirk ^a   Walz, Jochen ^a   Stalpers, Lukas J A ^b   Veninga, Theo ^c   Schulte, Rainer ^d   Obralic, Nermina ^e   Wildfang, Ingeborg ^f   Engenhart Cabilic, Rita ^g   Hoskin, Peter J ^h   Schild, Steven E ⁱ  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c DR BERNARD VERBEETEN INSTITUTE   (Netherlands)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e University in Sarajevo   (Bosnia and Herzegovina)

^f Hannover Hospital Siloah   (Germany)

^g PHILIPPS UNIVERSITY MARBURG   (Germany)

^h MOUNT VERNON CANCER CENTRE   (United Kingdom)

ⁱ MAYO CLINIC   (United States)

Author keywords

Metastatic spinal cord compression; Radiation therapy; Renal cell carcinoma

Indexed keywords

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER SURGERY; CONTROLLED STUDY; DETERIORATION; FEMALE; HUMAN; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOBILIZATION; MOTOR DYSFUNCTION; PERFORMANCE; PRIORITY JOURNAL; PROGNOSIS; SPINAL CORD COMPRESSION; SPINAL CORD METASTASIS; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SPINAL CORD COMPRESSION; SPINAL CORD NEOPLASMS; TREATMENT OUTCOME;

EID: 33645769291     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2005.11.004     Document Type: Article

References (26)

1. Patchell R., Tibbs P.A., Regine W.F., et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366 (2005) 643-648
2. Tatsui H., Onomura T., Morishita S., Oketa M., and Inoue T. Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation. Spine 21 (1996) 2143-2148
3. Van der Linden Y.M., Dijkstra S.P.D.S., Vonk E.J.A., Marijnen C.A.M., and Leer J.W.H. Prediction of survival in patients with metastases in the spinal column. Results based on a randomized trial of radiotherapy. Cancer 103 (2005) 320-328
4. Hoskin P.J., Grover A., and Bhana R. Metastatic spinal cord compression: radiotherapy outcome and dose fractionation. Radiother Oncol 68 (2003) 175-180
5. Sioutos P.J., Arbit E., Meshulam C.F., and Galicich J.H. Spinal metastases from solid tumors. Analysis of factors affecting survival. Cancer 76 (1995) 1453-1459
6. Prasad D., and Schiff D. Malignant spinal cord compression. Lancet Oncol 6 (2005) 15-24
7. Wilson D., Hiller L., Gray L., Grainger M., Stirling A., and James N. The effect of biological effective dose on time to symptom progression in metastatic renal cell carcinoma. Clin Oncol (R Coll Radiol) 15 (2003) 400-407
8. Tomita T., Galicich J.H., and Sundaresan N. Radiation therapy for spinal epidural metastases with complete block. Acta Radiol Oncol 22 (1983) 135-143
9. Trotti A., Byhardt R., Stetz J., et al. Common toxicity criteria: version 2.0. An improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys 47 (2000) 13-47
10. Koswig S., and Budach V. Re-calcification and pain relief following radiotherapy for bone metastases. A randomised trial of 2 different fractionation schedules (10 × 3 Gy vs. 1 × 8 Gy). Strahlenther Onkol 175 (1999) 500-508
11. Nielsen O.S., Bentzen S.M., Sandberg E., Gadeberg C.C., and Timothy A.R. Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases. Radiother Oncol 47 (1998) 233-240
12. On behalf of the Bone Pain Trial Working Party. 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomised comparison with a multifraction schedule over 12 months of patient follow-up. Radiother Oncol 52 (1999) 111-121
13. Steenland E., Leer J., van Houwelingen H., et al. The effect of a single fraction compared to multiple fraction on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study. Radiother Oncol 52 (1999) 101-109
14. Maranzano E., Latini P., Beneventi S., et al. Comparison of two different radiotherapy schedules for spinal cord compression in prostate cancer. Tumori 84 (1998) 472-477
15. Maranzano E., Bellavita R., Rossi R., et al. Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial. J Clin Oncol 23 (2005) 3358-3365
16. Rades D., Stalpers L.J.A., Hulshof M.C., et al. Comparison of 1 × 8 Gy and 10 × 3 Gy for functional outcome in patients with metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 62 (2005) 514-518
17. Barendsen G.W. Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 8 (1982) 1981-1997
18. Joiner M.C., and Van der Kogel A.J. The linear-quadratic approach to fractionation and calculation of isoeffect relationships. In: Steel G.G. (Ed). Basic clinical radiobiology. 2nd edition (1997), Oxford University Press, New York 106-112
19. Emami B., Lyman J., Brown A., et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21 (1991) 109-122
20. Rades D., Stalpers L.J.A., Veninga T., Schulte R., Hoskin P.J., and Alberti W. Effektivität und Toxizität einer Re-Bestrahlung (Re-RT) bei metastatisch bedingter Rückenmarkkompression (MBRK). Strahlenther Onkol 181 (2005) 595-600
21. Nieder C., Grosu A.L., Andtratschke N.H., and Molls M. Proposal of human spinal cord reirradiation dose based on collection of data from 40 patients. Int J Radiat Oncol Biol Phys 61 (2005) 851-855
22. Manabe S., Tanaka H., Higo Y., Park P., Ohno T., and Tateishi A. Experimental analysis of the spinal cord compressed by spinal metastasis. Spine 14 (1989) 1308-1315
23. Junker K., Romies I., Szendroi A., et al. Genetic profile of bone metastases in renal cell carcinoma. Eur Urol 45 (2004) 320-324
24. Patchell R.A., Tibbs P.A., Regine W.F., et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366 (2005) 643-648
25. Van den Bent M.J. Surgical resection improves outcome in metastatic epidural spinal cord compression. Lancet 366 (2005) 609-610
26. Maranzano E., Bellavita R., Rossi R., et al. Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial. J Clin Oncol 23 (2005) 3358-3365