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2-catalyzed annulation of 3d with 2a in MeOH gave 7d in 18% yield, which is better than the yield reported in ref 8a.
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3 or a reductant such as Zn resulted in similar or lower conversion of 3a. Furthermore, Pd(II) catalysts 10a-d turned out to be less effective than the Pd(O) catalyst and must not be reduced under the reaction conditions.
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3 or a reductant such as Zn resulted in similar or lower conversion of 3a. Furthermore, Pd(II) catalysts 10a-d turned out to be less effective than the Pd(O) catalyst and must not be reduced under the reaction conditions.
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