Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: Evidence for the involvement of nuclear factor-κB, a nitrosative stress-sensitive transcription factor, in the regulation

Drug Metabolism and Disposition

Volumn 35, Issue 11, 2007, Pages 1996-2005

  Maeng, Han Joo ^a   Kim, Mi Hwa ^a   Jin, Hyo Eon ^a   Sang, Mi Shin ^a   Tsuruo, Takasi ^b   Sang, Geon Kim ^a   Kim, Dae Duk ^a   Shim, Chang Koo ^a   Chung, Suk Jae ^a  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CYCLOSPORIN A; GLYCOPROTEIN P; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; METHYLENE BLUE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DNA BINDING; DRUG ADSORPTION; DRUG CLEARANCE; DRUG DETERMINATION; DRUG METABOLISM; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NITROSATIVE STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; TRANSCRIPTION INITIATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIOXIDANTS; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD GLUCOSE; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; FREE RADICAL SCAVENGERS; GENE EXPRESSION; MALE; MICE; NF-KAPPA B; NITRIC OXIDE DONORS; NITRITES; P-GLYCOPROTEIN; P-GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPEROXIDES;

RATTUS;

EID: 35548937851     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.015800     Document Type: Article

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