Pre-assembly of STAT4 with the human IFN-α/β receptor-2 subunit is mediated by the STAT4 N-domain

Molecular Immunology

Volumn 44, Issue 8, 2007, Pages 1864-1872

  Tyler, Douglas R ^a   Persky, Meredith E ^a   Matthews, Loderick A ^a   Chan, Sheuwen ^a   Farrar, J David ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cytokine receptors; Signal transduction; T cells

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; ALPHA2B INTERFERON; STAT4 PROTEIN; ALPHA BETA INTERFERON RECEPTOR; BETA INTERFERON; IFNAR2 PROTEIN, HUMAN; IFNAR2 PROTEIN, MOUSE; INTERLEUKIN 12; MULTIPROTEIN COMPLEX; STAT4 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; GENE DELETION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CYTOLOGY; FIBROBLAST; GENETICS; IMMUNOLOGY; MOUSE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; SPECIES DIFFERENCE;

MURINAE;

ANIMALS; CELL LINE; FIBROBLASTS; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; INTERLEUKIN-12; MICE; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; STAT4 TRANSCRIPTION FACTOR;

EID: 35548931300     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.10.006     Document Type: Article

References (39)

1. Bacon C.M., Petricoin III E.F., Ortaldo J.R., Rees R.C., Larner A.C., Johnston J.A., and O'Shea J.J. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 7307-7311
2. Beranger F., Aresta S., de Gunzburg J., and Camonis J. Getting more from the two-hybrid system: N-terminal fusions to LexA are efficient and sensitive baits for two-hybrid studies. Nucl. Acids Res. 25 (1997) 2035-2036
3. Berenson L.S., Farrar J.D., Murphy T.L., and Murphy K.M. Frontline: absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-alpha. Eur. J. Immunol. 34 (2004) 2365-2374
4. Brinkmann V., Geiger T., Alkan S., and Heusser C.H. Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells. J. Exp. Med. 178 (1993) 1655-1663
5. Chang H.C., Zhang S., Oldham I., Naeger L., Hoey T., and Kaplan M.H. STAT4 requires the N-terminal domain for efficient phosphorylation. J. Biol. Chem. 278 (2003) 32471-32477
6. Chen X., Bhandari R., Vinkemeier U., Van Den Akker F., Darnell Jr. J.E., and Kuriyan J. A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci. 12 (2003) 361-365
7. Cho S.S., Bacon C.M., Sudarshan C., Rees R.C., Finbloom D., Pine R., and O'Shea J.J. Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J. Immunol. 157 (1996) 4781-4789
8. Farrar J.D., and Murphy K.M. Type I interferons and T helper development. Immunol. Today 21 (2000) 484-489
9. Farrar J.D., Smith J.D., Murphy T.L., Leung S., Stark G.R., and Murphy K.M. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat. Immunol. 1 (2000) 65-69
10. Farrar J.D., Smith J.D., Murphy T.L., and Murphy K.M. Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2. J. Biol. Chem. 275 (2000) 2693-2697
11. Greenlund A.C., Morales M.O., Viviano B.L., Yan H., Krolewski J., and Schreiber R.D. Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity 2 (1995) 677-687
12. Heim M.H., Kerr I.M., Stark G.R., and Darnell Jr. J.E. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267 (1995) 1347-1349
13. Jacobson N.G., Szabo S.J., Weber-Nordt R.M., Zhong Z., Schreiber R.D., Darnell Jr. J.E., and Murphy K.M. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181 (1995) 1755-1762
14. Kaplan M.H., and Grusby M.J. Regulation of T helper cell differentiation by STAT molecules. J. Leukoc. Biol. 64 (1998) 2-5
15. Kaplan M.H., Sun Y.L., Hoey T., and Grusby M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382 (1996) 174-177
16. Krishnan K., Singh B., and Krolewski J.J. Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor. J. Biol. Chem. 273 (1998) 19495-19501
17. Li X., Leung S., Kerr I.M., and Stark G.R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell Biol. 17 (1997) 2048-2056
18. Matikainen S., Paananen A., Miettinen M., Kurimoto M., Timonen T., Julkunen I., and Sareneva T. IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12. Eur. J. Immunol. 31 (2001) 2236-2245
19. Murphy K.M., Ouyang W., Szabo S.J., Jacobson N.G., Guler M.L., Gorham J.D., Gubler U., and Murphy T.L. T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases. Curr. Top Microbiol. Immunol. 238 (1999) 13-26
20. Murphy T.L., Geissal E.D., Farrar J.D., and Murphy K.M. Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. Mol. Cell Biol. 20 (2000) 7121-7131
21. Naeger L.K., McKinney J., Salvekar A., and Hoey T. Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling. J. Biol. Chem. 274 (1999) 1875-1878
22. Ota N., Brett T.J., Murphy T.L., Fremont D.H., and Murphy K.M. N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nat. Immunol. 5 (2004) 208-215
23. Park C., Lecomte M.J., and Schindler C. Murine Stat2 is uncharacteristically divergent. Nucl. Acids Res. 27 (1999) 4191-4199
24. Parronchi P., De Carli M., Manetti R., Simonelli C., Sampognaro S., Piccinni M.P., Macchia D., Maggi E., Del Prete G., and Romagnani S. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J. Immunol. 149 (1992) 2977-2983
25. Paulson M., Pisharody S., Pan L., Guadagno S., Mui A.L., and Levy D.E. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. J. Biol. Chem. 274 (1999) 25343-25349
26. Persky M.E., Murphy K.M., and Farrar J.D. IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene. J. Immunol. 174 (2005) 294-301
27. Rogge L., D'Ambrosio D., Biffi M., Penna G., Minetti L.J., Presky D.H., Adorini L., and Sinigaglia F. The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J. Immunol. 161 (1998) 6567-6574
28. Sareneva T., Julkunen I., and Matikainen S. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. J. Immunol. 165 (2000) 1933-1938
29. Sareneva T., Matikainen S., Kurimoto M., and Julkunen I. Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells. J. Immunol. 160 (1998) 6032-6038
30. Sinigaglia F., D'Ambrosio D., and Rogge L. Type I interferons and the Th1/Th2 paradigm. Dev. Comp. Immunol. 23 (1999) 657-663
31. Szabo S.J., Dighe A.S., Gubler U., and Murphy K.M. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185 (1997) 817-824
32. Szabo S.J., Jacobson N.G., Dighe A.S., Gubler U., and Murphy K.M. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2 (1995) 665-675
33. Szabo S.J., Sullivan B.M., Peng S.L., and Glimcher L.H. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21 (2003) 713-758
34. Thierfelder W.E., van Deursen J.M., Yamamoto K., Tripp R.A., Sarawar S.R., Carson R.T., Sangster M.Y., Vignali D.A., Doherty P.C., Grosveld G.C., and Ihle J.N. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382 (1996) 171-174
35. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3 (2003) 133-146
36. Vinkemeier U., Moarefi I., Darnell Jr. J.E., and Kuriyan J. Structure of the amino-terminal protein interaction domain of STAT-4. Science 279 (1998) 1048-1052
37. Wenner C.A., Guler M.L., Macatonia S.E., O'Garra A., and Murphy K.M. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J. Immunol. 156 (1996) 1442-1447
38. Wiederkehr-Adam M., Ernst P., Muller K., Bieck E., Gombert F.O., Ottl J., Graff P., Grossmuller F., and Heim M.H. Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3. J. Biol. Chem. 278 (2003) 16117-16128
39. Yan H., Krishnan K., Greenlund A.C., Gupta S., Lim J.T., Schreiber R.D., Schindler C.W., and Krolewski J.J. Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. Embo. J. 15 (1996) 1064-1074