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Volumn 3, Issue 3, 2007, Pages 185-191

TGF-β regulates invasive behavior of human pancreatic cancer cells by controlling Smad expression

Author keywords

Growth factor; Pancreatic cancer; Tumor invasion

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIBODY; BETA ACTIN; MATRIGEL; MESSENGER RNA; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 35449005284     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (5)

References (49)
  • 2
    • 22844436349 scopus 로고    scopus 로고
    • Adjuvant treatment for resectable pancreatic cancer
    • Chua YJ, Cunningham D. Adjuvant treatment for resectable pancreatic cancer. J Clin Oncol 2005; 23:4532-7.
    • (2005) J Clin Oncol , vol.23 , pp. 4532-4537
    • Chua, Y.J.1    Cunningham, D.2
  • 3
    • 12144287320 scopus 로고    scopus 로고
    • A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    • Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 2004; 350: 1200-10.
    • (2004) N Engl J Med , vol.350 , pp. 1200-1210
    • Neoptolemos, J.P.1    Stocken, D.D.2    Friess, H.3
  • 4
    • 0036848885 scopus 로고    scopus 로고
    • Suppression of tumorigenesis and induction of p15ink4b by Smad4/DPC4 in human pancreatic cancer cells
    • Peng B, Fleming JB, Breslin T, et al. Suppression of tumorigenesis and induction of p15ink4b by Smad4/DPC4 in human pancreatic cancer cells. Clin Cancer Res 2002; 8: 3628-38.
    • (2002) Clin Cancer Res , vol.8 , pp. 3628-3638
    • Peng, B.1    Fleming, J.B.2    Breslin, T.3
  • 5
    • 0041922583 scopus 로고    scopus 로고
    • Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer
    • Sawai H, Funahashi H, Yamamoto M, et al. Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer. Oncology 2003; 65:167-73.
    • (2003) Oncology , vol.65 , pp. 167-173
    • Sawai, H.1    Funahashi, H.2    Yamamoto, M.3
  • 6
    • 25444494176 scopus 로고    scopus 로고
    • Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells
    • Shirk AJ, Kuver R. Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells. BMC Gastroenterol 2005; 5: 12.
    • (2005) BMC Gastroenterol , vol.5 , pp. 12
    • Shirk, A.J.1    Kuver, R.2
  • 7
    • 18144422437 scopus 로고    scopus 로고
    • Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells
    • El Fitori J, Kleeff J, Giese NA, et al. Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells. Cancer Cell Int 2005; 5: 3.
    • (2005) Cancer Cell Int , vol.5 , pp. 3
    • El Fitori, J.1    Kleeff, J.2    Giese, N.A.3
  • 8
    • 0035860239 scopus 로고    scopus 로고
    • Expression of TGF-beta signaling genes in the normal, premalignant, and malignant human trophoblast: Loss of Smad3 in choriocarcinaoma cells
    • Xu G, Chakraborty C, Lala PK. Expression of TGF-beta signaling genes in the normal, premalignant, and malignant human trophoblast: loss of Smad3 in choriocarcinaoma cells. Biochem Biophys Res Commun 2001; 287:47-55.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 47-55
    • Xu, G.1    Chakraborty, C.2    Lala, P.K.3
  • 9
    • 0035701641 scopus 로고    scopus 로고
    • Negative effect of transforming growth factor-beta-1 on intestinal anastomotic tissue regeneration
    • Fukuda H, Motohiro T, Nakai K, et al. Negative effect of transforming growth factor-beta-1 on intestinal anastomotic tissue regeneration. Eur Surg Res 2001; 33: 388-94.
    • (2001) Eur Surg Res , vol.33 , pp. 388-394
    • Fukuda, H.1    Motohiro, T.2    Nakai, K.3
  • 10
    • 10444259625 scopus 로고    scopus 로고
    • TGF betal and PDGF AA override collagen type I inhibition of proliferation in human liver connective tissue cells
    • Geremias AT, Carvalho MA, Borojevic R, Monteiro ANA TGF betal and PDGF AA override collagen type I inhibition of proliferation in human liver connective tissue cells. BMC Gastroenterol 2004; 4: 30.
    • (2004) BMC Gastroenterol , vol.4 , pp. 30
    • Geremias, A.T.1    Carvalho, M.A.2    Borojevic, R.3    Monteiro, A.N.A.4
  • 11
    • 0037444273 scopus 로고    scopus 로고
    • Loss of c-myc repression coincides with ovarian cancer resistance to transforming growth factor beta growth arrest independent of transforming growth factor beta/Smad signaling
    • Baldwin RL, Tran H, Karlan BY. Loss of c-myc repression coincides with ovarian cancer resistance to transforming growth factor beta growth arrest independent of transforming growth factor beta/Smad signaling. Cancer Res 2003; 63: 1413-9.
    • (2003) Cancer Res , vol.63 , pp. 1413-1419
    • Baldwin, R.L.1    Tran, H.2    Karlan, B.Y.3
  • 12
    • 0037444161 scopus 로고    scopus 로고
    • Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling
    • Suh N, Roberts AB, Birkey Reffey S, et al. Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Cancer Res 2003; 63: 1371-6.
    • (2003) Cancer Res , vol.63 , pp. 1371-1376
    • Suh, N.1    Roberts, A.B.2    Birkey Reffey, S.3
  • 13
    • 0042066370 scopus 로고    scopus 로고
    • Loss of expression, and mutations of Smad2 and Smad4 in human cervical cancer
    • Maliekal TT, Antony ML, Nair A, Paulmurugan R, Karunagaran D. Loss of expression, and mutations of Smad2 and Smad4 in human cervical cancer. Oncogene 2003; 22: 4889-97.
    • (2003) Oncogene , vol.22 , pp. 4889-4897
    • Maliekal, T.T.1    Antony, M.L.2    Nair, A.3    Paulmurugan, R.4    Karunagaran, D.5
  • 14
    • 2942571940 scopus 로고    scopus 로고
    • Is telomerase reactivation associated with the down-regulation of TGF beta receptor-II expression in human breast cancer?
    • Elkak AE, Newbold RF, Thomas V, Mokbel K. Is telomerase reactivation associated with the down-regulation of TGF beta receptor-II expression in human breast cancer? Cancer Cell Int 2003; 3: 9.
    • (2003) Cancer Cell Int , vol.3 , pp. 9
    • Elkak, A.E.1    Newbold, R.F.2    Thomas, V.3    Mokbel, K.4
  • 15
    • 0842284200 scopus 로고    scopus 로고
    • Woszczyk D, Gola J, Jurzak M, Mazurek U, Mykala-Cieśla J, Wilczok T. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Med Sci Monit 2004; 10: CR33-7.
    • Woszczyk D, Gola J, Jurzak M, Mazurek U, Mykala-Cieśla J, Wilczok T. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Med Sci Monit 2004; 10: CR33-7.
  • 16
    • 0032571373 scopus 로고    scopus 로고
    • Up-regulation of transforming growth factor (TGF)-beta receptors by TGF-beta1 in COLO-357 cells
    • Kleeff J, Korc M. Up-regulation of transforming growth factor (TGF)-beta receptors by TGF-beta1 in COLO-357 cells. J Biol Chem 1998; 273: 7495-500.
    • (1998) J Biol Chem , vol.273 , pp. 7495-7500
    • Kleeff, J.1    Korc, M.2
  • 17
    • 0032939213 scopus 로고    scopus 로고
    • Ligand induced upregulation of the type II transforming growth factor (TGF-beta) receptor enhances TGF-beta responsiveness in COLO-357 cells
    • Kleeff J, Wildi S, Friess H, Korc M. Ligand induced upregulation of the type II transforming growth factor (TGF-beta) receptor enhances TGF-beta responsiveness in COLO-357 cells. Pancreas 1999; 18: 364-70.
    • (1999) Pancreas , vol.18 , pp. 364-370
    • Kleeff, J.1    Wildi, S.2    Friess, H.3    Korc, M.4
  • 18
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001; 29: 117-29.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 19
    • 0036467496 scopus 로고    scopus 로고
    • TGF-beta signaling: Positive and negative effects on tumorigenesis
    • Wakefield LM, Roberts AB. TGF-beta signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev 2002; 12: 22-9.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 20
    • 13944267911 scopus 로고    scopus 로고
    • The effect of TGFbeta1 on the expression and phosphorylation of key cell-cycle regulators in malignant B cells
    • Tvrdik D. The effect of TGFbeta1 on the expression and phosphorylation of key cell-cycle regulators in malignant B cells. Med Sci Monit 2004; 10: BR447-54.
    • (2004) Med Sci Monit , vol.10
    • Tvrdik, D.1
  • 21
    • 0037158512 scopus 로고    scopus 로고
    • TGF-β inducible early gene enhances TGF-β/Smad-dependent transcriptional responses
    • Johnsen SA, Subramanian M, Janknecht R, Speisberg TC. TGF-β inducible early gene enhances TGF-β/Smad-dependent transcriptional responses. Oncogene 2002; 21: 5783-90.
    • (2002) Oncogene , vol.21 , pp. 5783-5790
    • Johnsen, S.A.1    Subramanian, M.2    Janknecht, R.3    Speisberg, T.C.4
  • 22
    • 0141793857 scopus 로고    scopus 로고
    • The p38 MARK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells
    • Fu Y, O'Connor LM, Shepherd TG, Nachtigal MW. The p38 MARK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun 2003; 310: 391-7.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 391-397
    • Fu, Y.1    O'Connor, L.M.2    Shepherd, T.G.3    Nachtigal, M.W.4
  • 23
    • 0037108882 scopus 로고    scopus 로고
    • Compound disruption of Smad2 accelerates malignant progression of intestinal tumors in ape knockout mice
    • Hamamoto T, Beppu H, Okada H, et al. Compound disruption of Smad2 accelerates malignant progression of intestinal tumors in ape knockout mice. Cancer Res 2002; 62: 5955-61.
    • (2002) Cancer Res , vol.62 , pp. 5955-5961
    • Hamamoto, T.1    Beppu, H.2    Okada, H.3
  • 24
    • 0038548187 scopus 로고    scopus 로고
    • Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest
    • Nicolas FJ, Hill CS. Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest. Oncogene 2003; 22: 3698-711.
    • (2003) Oncogene , vol.22 , pp. 3698-3711
    • Nicolas, F.J.1    Hill, C.S.2
  • 25
    • 0041314104 scopus 로고    scopus 로고
    • Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells
    • Shepard TG, Nachtigal MW. Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells. Endocrinology 2003; 144: 3306-14.
    • (2003) Endocrinology , vol.144 , pp. 3306-3314
    • Shepard, T.G.1    Nachtigal, M.W.2
  • 26
    • 0037411141 scopus 로고    scopus 로고
    • Involvement of Smad proteins in TGF-beta and activin A-induced apoptosis and growth inhibition of liver cells
    • Kanamaru C, Yasuda H, Fujita T. Involvement of Smad proteins in TGF-beta and activin A-induced apoptosis and growth inhibition of liver cells. Hepatol Res 2002; 23: 211-9.
    • (2002) Hepatol Res , vol.23 , pp. 211-219
    • Kanamaru, C.1    Yasuda, H.2    Fujita, T.3
  • 27
    • 0041589137 scopus 로고    scopus 로고
    • Inhibition of the antiproliferative effect of TGF-beta by EGF in primary human ovarian cancer cells
    • Dunfield LD, Nachtigal MW. Inhibition of the antiproliferative effect of TGF-beta by EGF in primary human ovarian cancer cells. Oncogene 2003; 22: 4745-51.
    • (2003) Oncogene , vol.22 , pp. 4745-4751
    • Dunfield, L.D.1    Nachtigal, M.W.2
  • 28
    • 0032442852 scopus 로고    scopus 로고
    • Smads: Transcriptional activators of TGF-beta responses
    • Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-beta responses. Cell 1998; 95: 737-40.
    • (1998) Cell , vol.95 , pp. 737-740
    • Derynck, R.1    Zhang, Y.2    Feng, X.H.3
  • 29
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
    • Hayashi H, Abdollah S, Qiu Y, et al. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 1997; 89: 1165-73.
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1    Abdollah, S.2    Qiu, Y.3
  • 30
    • 0031685620 scopus 로고    scopus 로고
    • Massague J. TGF-β signal transduction. Annu Rev Biochem 1998; 67: 753-91.
    • Massague J. TGF-β signal transduction. Annu Rev Biochem 1998; 67: 753-91.
  • 31
    • 11144356448 scopus 로고    scopus 로고
    • Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence SMAD4 expression
    • Imamura T, Kanai F, Kawakami T, et al. Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence SMAD4 expression. Biochem Biophys Res Commun 2004; 318: 289-96.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 289-296
    • Imamura, T.1    Kanai, F.2    Kawakami, T.3
  • 32
    • 0035879867 scopus 로고    scopus 로고
    • TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system
    • Ellenrieder V, Hendler SF, Ruhland C, Boeck W, Adler G, Gress TM. TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system. Int J Cancer 2001; 93: 204-11.
    • (2001) Int J Cancer , vol.93 , pp. 204-211
    • Ellenrieder, V.1    Hendler, S.F.2    Ruhland, C.3    Boeck, W.4    Adler, G.5    Gress, T.M.6
  • 33
    • 33745795090 scopus 로고    scopus 로고
    • Fibroblast growth factors promote pancreatic cell proliferation in normal and STZ-treated hamsters
    • Inchovska M, Ogneva V, Martinova Y. Fibroblast growth factors promote pancreatic cell proliferation in normal and STZ-treated hamsters. Arch Med Sci 2006; 2: 90-3.
    • (2006) Arch Med Sci , vol.2 , pp. 90-93
    • Inchovska, M.1    Ogneva, V.2    Martinova, Y.3
  • 34
    • 0027131252 scopus 로고
    • Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival
    • Friess H, Yamanaka Y, Büchler M, et al. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology 1993; 105: 1846-56.
    • (1993) Gastroenterology , vol.105 , pp. 1846-1856
    • Friess, H.1    Yamanaka, Y.2    Büchler, M.3
  • 35
    • 0141443965 scopus 로고    scopus 로고
    • Interfering with TGFbeta-induced Smad3 nuclear accumulation differentially affects TGFbeta-dependent gene expression
    • Lindemann RK, Nordheim A, Dittmer J. Interfering with TGFbeta-induced Smad3 nuclear accumulation differentially affects TGFbeta-dependent gene expression. Mol Cancer 2003; 2: 20.
    • (2003) Mol Cancer , vol.2 , pp. 20
    • Lindemann, R.K.1    Nordheim, A.2    Dittmer, J.3
  • 36
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996; 271: 350-3.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 37
    • 0037133596 scopus 로고    scopus 로고
    • Deficient Smad 7 expression: A putative molecular defect in scleroderma
    • Dong C, Zhu S, Wang T, et al. Deficient Smad 7 expression: a putative molecular defect in scleroderma. Proc Natl Acad Sci USA 2002; 99: 3908-13.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3908-3913
    • Dong, C.1    Zhu, S.2    Wang, T.3
  • 38
    • 0033573974 scopus 로고    scopus 로고
    • Smad6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer
    • Kleeff J, Maruyama H, Friess H, Büchler MW, Falb D, Korc M. Smad6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer. Biochem Biophys Res Commun 1999; 255: 268-73.
    • (1999) Biochem Biophys Res Commun , vol.255 , pp. 268-273
    • Kleeff, J.1    Maruyama, H.2    Friess, H.3    Büchler, M.W.4    Falb, D.5    Korc, M.6
  • 39
    • 0033598408 scopus 로고    scopus 로고
    • The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
    • Kleeff J, Ishiwata T, Maruyama H, et al. The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Oncogene 1999; 18: 5363-72.
    • (1999) Oncogene , vol.18 , pp. 5363-5372
    • Kleeff, J.1    Ishiwata, T.2    Maruyama, H.3
  • 41
    • 33751251034 scopus 로고    scopus 로고
    • Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    • Bardeesy N, Cheng KH, Berger JH, et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 2007; 20: 3130-46.
    • (2007) Genes Dev , vol.20 , pp. 3130-3146
    • Bardeesy, N.1    Cheng, K.H.2    Berger, J.H.3
  • 42
    • 33847387472 scopus 로고    scopus 로고
    • Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to include mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
    • Izeradjene K, Combs C, Best M, et al. Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to include mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 2007; 11: 229-43.
    • (2007) Cancer Cell , vol.11 , pp. 229-243
    • Izeradjene, K.1    Combs, C.2    Best, M.3
  • 43
    • 0035879867 scopus 로고    scopus 로고
    • TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system
    • Ellenrieder V, Hendler SF, Ruhland C, Boeck W, Adler G, Gress TM. TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system. Int J Cancer 2001; 93: 204-11.
    • (2001) Int J Cancer , vol.93 , pp. 204-211
    • Ellenrieder, V.1    Hendler, S.F.2    Ruhland, C.3    Boeck, W.4    Adler, G.5    Gress, T.M.6
  • 44
    • 0043068003 scopus 로고    scopus 로고
    • p38 MAP kinase modulates Smad-dependent changes in human prostate cell adhesion
    • Hayes SA, Huang X, Kambhampati S, Platanias LC, Bergan RC. p38 MAP kinase modulates Smad-dependent changes in human prostate cell adhesion. Oncogene 2003; 22:4841-50.
    • (2003) Oncogene , vol.22 , pp. 4841-4850
    • Hayes, S.A.1    Huang, X.2    Kambhampati, S.3    Platanias, L.C.4    Bergan, R.C.5
  • 45
    • 24644476507 scopus 로고    scopus 로고
    • Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: Implications for carcinogenesis
    • Javelaud D, Mauviel A. Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis. Oncogene 2005; 24: 5742-50.
    • (2005) Oncogene , vol.24 , pp. 5742-5750
    • Javelaud, D.1    Mauviel, A.2
  • 46
    • 33751247898 scopus 로고    scopus 로고
    • Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    • Ijichi H, Chytil A, Gorska AE, et al. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev 2006; 20: 3147-60.
    • (2006) Genes Dev , vol.20 , pp. 3147-3160
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3
  • 47
    • 3042618951 scopus 로고    scopus 로고
    • N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma
    • Nakajima S, Doi R, Toyoda E, et al. N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res 2004; 10: 4125-33.
    • (2004) Clin Cancer Res , vol.10 , pp. 4125-4133
    • Nakajima, S.1    Doi, R.2    Toyoda, E.3
  • 48
    • 21844450693 scopus 로고    scopus 로고
    • Involvement of microtubules and Rho pathway in TGF-betal-induced lung vascular barrier dysfunction
    • Birukova AA, Birukov KG, Adyshev D, et al. Involvement of microtubules and Rho pathway in TGF-betal-induced lung vascular barrier dysfunction. J Cell Physiol 2005; 204: 934-47.
    • (2005) J Cell Physiol , vol.204 , pp. 934-947
    • Birukova, A.A.1    Birukov, K.G.2    Adyshev, D.3
  • 49
    • 34250623251 scopus 로고    scopus 로고
    • Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes
    • Qureshi HY, Ahmad R, Sylvester J, Zafarullah M. Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes. Cell Signal 2007; 19: 1643-51.
    • (2007) Cell Signal , vol.19 , pp. 1643-1651
    • Qureshi, H.Y.1    Ahmad, R.2    Sylvester, J.3    Zafarullah, M.4


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