The role of intracellular peroxide levels on the development and maintenance of telomere-dependent senescence

Experimental Gerontology

Volumn 42, Issue 11, 2007, Pages 1043-1052

  Richter, Torsten ^a,b   Proctor, Carole ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Mathematical model; Oxidative stress; Stochastic simulation; Telomere uncapping; Telomere dependent senescence

Indexed keywords

PEROXIDE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL POPULATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE; SIMULATION; STOCHASTIC MODEL; TELOMERE;

CELL AGING; DNA DAMAGE; DNA REPAIR; FEEDBACK, BIOCHEMICAL; FIBROBLASTS; HUMANS; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PEROXIDES; REACTIVE OXYGEN SPECIES; STOCHASTIC PROCESSES; TELOMERE;

EID: 35449002467     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2007.08.004     Document Type: Article

References (25)

1. Arino O., Kimmel M., and Webb G.F. Mathematical modeling of the loss of telomere sequences. J. Theor. Biol. 177 (1995) 45-57
2. Campisi J. Suppressing cancer: the importance of being senescent. Science 309 (2005) 886-887
3. Felley-Bosco E. Role of nitric oxide in genotoxicity: implication for carcinogenesis. Cancer Metastasis Rev. 17 (1998) 25-37
4. Hucka M., Finney A., Sauro H.M., Bolouri H., Doyle J.C., Kitano H., Arkin A.P., Bornstein B.J., Bray D., Cornish-Bowden A., Cuellar A.A., Dronov S., Gilles E.D., Ginkel M., Gor V., Goryanin I.I., Hedley W.J., Hodgman T.C., Hofmeyr J.H., Hunter P.J., Juty N.S., Kasberger J.L., Kremling A., Kummer U., Le Novere N., Loew L.M., Lucio D., Mendes P., Minch E., Mjolsness E.D., Nakayama Y., Nelson M.R., Nielsen P.F., Sakurada T., Schaff J.C., Shapiro B.E., Shimizu T.S., Spence H.D., Stelling J., Takahashi K., Tomita M., Wagner J., and Wang J. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19 (2003) 524-531
5. Kirkwood T.B., Boys R.J., Gillespie C.S., Proctor C.J., Shanley D.P., and Wilkinson D.J. Towards an e-biology of ageing: integrating theory and data. Nat. Rev. Mol. Cell. Biol. 4 (2003) 243-249
6. Lee A.C., Fenster B.E., Ito H., Takeda K., Bae N.S., Hirai T., Yu Z.X., Ferrans V.J., Howard B.H., and Finkel T. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274 (1999) 7936-7940
7. Levy M.Z., Allsopp R.C., Futcher A.B., Greider C.W., and Harley C.B. Telomere end-replication problem and cell aging. J. Mol. Biol. 225 (1992) 951-960
8. Macip S., Igarashi M., Fang L., Chen A., Pan Z.Q., Lee S.W., and Aaronson S.A. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. Embo. J. 21 (2002) 2180-2188
9. Martens U.M., Chavez E.A., Poon S.S., Schmoor C., and Lansdorp P.M. Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp. Cell Res. 256 (2000) 291-299
10. Mitra S., Boldogh I., Izumi T., and Hazra T.K. Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage. Environ. Mol. Mutagen. 38 (2001) 180-190
11. Moiseeva O., Mallette F.A., Mukhopadhyay U.K., Moores A., and Ferbeyre G. DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol. Biol. Cell 17 (2006) 1583-1592
12. Olovnikov A.M. Principle of marginotomy in template synthesis of polynucleotides. Dokl. Akad. Nauk. SSSR 201 (1971) 1496-1499
13. Proctor C.J., and Kirkwood T.B. Modelling telomere shortening and the role of oxidative stress. Mech. Ageing Dev. 123 (2002) 351-363
14. Proctor C.J., and Kirkwood T.B. Modelling cellular senescence as a result of telomere state. Aging Cell 2 (2003) 151-157
15. Richter T., and von Zglinicki T. Oxidative DNA damage and telomere shortening. In: Evans M.D., and Cooke M.S. (Eds). Oxidative damage to nucleic acids (2006), Landes Bioscience, Georgetown, TX
16. Richter, T., von Zglinicki, T., 2007. A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp. Gerontol., in press, doi:10.1016/j.exger.2007.08.005.
17. Rivera-Nieves J., Thompson W.C., Levine R.L., and Moss J. Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenase. J. Biol. Chem. 274 (1999) 19525-19531
18. Sfeir A.J., Shay J.W., and Wright W.E. Fine-tuning the chromosome ends: the last base of human telomeres. Cell Cycle 4 (2005) 1467-1470
19. Sozou P.D., and Kirkwood T.B. A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. J. Theor. Biol. 213 (2001) 573-586
20. Takahashi A., Ohtani N., Yamakoshi K., Iida S., Tahara H., Nakayama K., Nakayama K.I., Ide T., Saya H., and Hara E. Mitogenic signalling and the p16(INK4a)-Rb pathway cooperate to enforce irreversible cellular senescence. Nat. Cell Biol. 8 (2006) 1291-1297
21. Tan Z. Telomere shortening and the population size-dependency of life span of human cell culture: further implication for two proliferation-restricting telomeres. Exp. Gerontol. 34 (1999) 831-842
22. von Zglinicki T. Role of oxidative stress in telomere length regulation and replicative senescence. Ann. N Y Acad. Sci. 908 (2000) 99-110
23. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem. Sci. 27 (2002) 339-344
24. von Zglinicki T., and Martin-Ruiz C.M. Telomeres as biomarkers for ageing and age-related diseases. Curr. Mol. Med. 5 (2005) 197-203
25. Zou Y., Sfeir A., Gryaznov S.M., Shay J.W., and Wright W.E. Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?. Mol. Biol. Cell 15 (2004) 3709-3718