Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: Possible role of a dihydropyrimidine dehydrogenase-independent mechanism

Journal of Gastroenterology

Volumn 42, Issue 10, 2007, Pages 816-822

  Sasaki, Eiji ^a   Tominaga, Kazunari ^a   Kuwamura, Hikaru ^a   Watanabe, Toshio ^a   Fujiwara, Yasuhiro ^a   Oshitani, Nobuhide ^a   Higuchi, Kazuhide ^a   Arakawa, Tetsuo ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

5 fluorouracil; CDHP; Gastric cancer; S 1; Thymidylate synthase

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; MESSENGER RNA; OROTATE PHOSPHORIBOSYLTRANSFERASE; THYMIDYLATE SYNTHASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CELL ASSAY; CELL COUNT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; DIHYDROURACIL DEHYDROGENASE (NADP); DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; OXONIC ACID; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; TEGAFUR; THYMIDYLATE SYNTHASE;

EID: 35448996375     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-007-2101-5     Document Type: Article

References (22)

1. CK Carrico RI Glazer 1979 Effect of 5-fluorouracil on the synthesis and translation of polyadenylic acid-containing RNA from regenerating rat liver Cancer Res 39 3694-701 476694 1:CAS:528:DyaE1MXlvVKlur8%3D
2. WB Parker YC Cheng 1990 Metabolism and mechanism of action of 5-fluorouracil Pharmacol Ther 48 381-95 1707544 10.1016/ 0163-7258(90)90056-8 1:CAS:528:DyaK3MXkt1Wns7w%3D
3. H Fujiwara M Terashima T Irinoda A Takagane K Abe T Nakaya 2003 Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity Eur J Cancer 39 2387-94 14556932 10.1016/ S0959-8049(03)00513-6 1:CAS:528:DC%2BD3sXnvVymur4%3D
4. GJ Peters CL van der Wilt B van Triest G Codacci-Pisanelli PG Johnston CJ van Groeningen 1995 Thymidylate synthase and drug resistance Eur J Cancer 31A 1299-305 7577040 10.1016/0959-8049(95)00172-F 1:CAS:528:DyaK2MXotVOmt7s%3D
5. M Tanaka-Nozaki T Tajiri N Tanaka K Furuhara H Takasaki K Yoshimura 2003 Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: Association with survival Oncol Rep 10 1425-9 12883718 1:CAS:528:DC%2BD3sXmvFWnsrg%3D
6. Y Kirihara W Yamamoto T Toge M Nishiyama 1999 Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells Int J Oncol 14 551-6 10024690 1:CAS:528:DyaK1MXhs12iuro%3D
7. CP Spears AH Shahinian RG Moran C Heidelberger TH Corbett 1982 In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas Cancer Res 42 450-6 6173112 1:CAS:528:DyaL38XhtlGntrs%3D
8. ME Kitchens AM Forsthoefel KW Barbour HT Spencer FG Berger 1999 Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability Mol Pharmacol 56 1063-70 10531414 1:CAS:528:DyaK1MXntV2ls74%3D
9. T Shirasaka Y Shimamato H Ohshimo M Yamaguchi T Kato K Yonekura 1996 Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators Anticancer Drugs 7 548-57 8862723 10.1097/00001813-199607000-00010 1:CAS:528:DyaK28Xltleru78%3D
10. Y Sakata A Ohtsu N Horikoshi K Sugimachi Y Mitachi T Taguchi 1998 Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1-M tegafur-0.4-M gimestat-1-M otastat potassium) in advanced gastric cancer patients Eur J Cancer 34 1715-20 9893658 10.1016/S0959-8049(98)00211-1 1:CAS:528:DyaK1cXntlShurw%3D
11. Y Tsukioka Y Matsumura T Hamaguchi M Goto K Muro Y Yamada 2001 Complete response achieved following administration of S-1 in a patient with adrenal gland metastasis of 5-FU-resistant gastric cancer: A case report Jpn J Clin Oncol 31 450-3 11689601 10.1093/jjco/hye091 1:STN:280:DC%2BD3Mnjs1GntA%3D%3D
12. M Inaba J Mitsuhashi H Sawada N Miike Y Naoe A Daimon 1996 Reduced activity of anabolizing enzymes in 5-fluorouracil-resistant human stomach cancer cells Jpn J Cancer Res 87 212-20 8609072 1:CAS:528:DyaK28XhsFCntLw%3D
13. J Kurebayashi Y Yamamoto K Udagawa S Okubo M Fukushima H Sonoo 2004 Establishment of enzyme-linked immunosorbent assays for thymidylate synthase and dihydropyriminide dehydrogenase in cancer tissues Oncol Rep 11 973-9 15069534 1:CAS:528:DC%2BD2cXjslGksro%3D
14. M Hamaguchi Y Fujiwara T Takashima T Hayakawa E Sasaki M Shiba 2003 Increased expression of cytokines and adhesion molecules in rat chronic esophagitis Digestion 68 189-97 14691346 10.1159/000075698 1:CAS:528:DC%2BD2cXhtlygu7o%3D
15. K Mori M Hasegaw M Nishida H Toma M Fukuda T Kubota 2000 Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues Int J Oncol 17 33-8 10853015 1:CAS:528:DC%2BD3cXksV2rurs%3D
16. A Beck MC Etienne S Cheradame JL Fischel P Formento N Renee 1994 A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil Eur J Cancer 30A 1517-22 7833111 10.1016/ 0959-8049(94)00216-R 1:CAS:528:DyaK2MXit1Wls7o%3D
17. T Takechi K Koizumi H Tsujimoto M Fukushima 2001 Screening of differentially expressed genes in 5-fluorouracil-resistant human gastrointestinal tumor cells Jpn J Cancer Res 92 696-703 11429060 1:CAS:528:DC%2BD3MXlslOit7g%3D
18. G Johnston HJ Lenz CG Leichman KD Danenberg CJ Allegra PV Danenberg 1995 Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors Cancer Res 55 1407-12 7882343 1:CAS:528:DyaK2MXkslWis7c%3D
19. HJ Lenz CG Leichman KD Danenberg PV Danenberg S Groshen S Cohen 1996 Thymidylate synthase mRNA level in adenocarcinoma of the stomach: A predictor for primary tumor response and overall survival J Clin Oncol 14 176-82 8558194 1:STN:280:BymC2c%2FivFM%3D
20. CH Takimoto DB Voeller JM Strong L Anderson E Chu CJ Allegra 1993 Effects of 5-fluorouracil substitution on the RNA conformation and in vitro translation of thymidylate synthase messenger RNA J Biol Chem 268 21438-42 8407987 1:CAS:528:DyaK3sXlsFWktLk%3D
21. Y Ishikawa T Kubota Y Otani M Watanabe T Teramoto K Kumai 1999 Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice Clin Cancer Res 5 883-9 10213225 1:CAS:528:DyaK1MXislOnsbo%3D
22. H Fujiwara M Terashima T Irinoda A Takagane K Abe M Kashiwaba 2002 Quantitative measurement of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level in gastric cancer by real-time RT-PCR Jpn J Cancer Res 93 1342-50 12495474 1:CAS:528:DC%2BD3sXht12qtr8%3D