Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites

Experimental Cell Research

Volumn 312, Issue 20, 2006, Pages 4049-4055

  Lenz, Bernd ^a   Bleich, Stefan ^a   Beutler, Sonja ^a   Schlierf, Beate ^a   Schwager, Katja ^b   Reulbach, Udo ^a   Kornhuber, Johannes ^a   Bönsch, Dominikus ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

AARE; CpG islands; CREB; DNA methylation; Herp; Homocysteine

Indexed keywords

AMINO ACID; CALCIUM ION; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; HOMOCYSTEINE; LUCIFERASE; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN HERP; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CELL LINE; CELL STIMULATION; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; ENZYME ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; NERVE CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RNA ANALYSIS;

EID: 35448977229     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.09.004     Document Type: Article

References (29)

1. Kokame K., Kato H., and Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J. Biol. Chem. 271 (1996) 29659-29665
2. Outinen P.A., Sood S.K., Liaw P.C., Sarge K.D., Maeda N., Hirsh J., Ribau J., Podor T.J., Weitz J.I., and Austin R.C. Characterization of the stress-inducing effects of homocysteine. Biochem. J. 332 (1998) 213-221
3. Althausen S., and Paschen W. Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures. Brain Res. Mol. Brain Res. 84 (2000) 32-40
4. Nonaka H., Tsujino T., Watari Y., Emoto N., and Yokoyama M. Taurine prevents the decrease in expression and secretion of extracellular superoxide dismutase induced by homocysteine: amelioration of homocysteine-induced endoplasmic reticulum stress by taurine. Circulation 104 (2001) 1165-1170
5. Kokame K., Agarwala K.L., Kato H., and Miyata T. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. J. Biol. Chem. 275 (2000) 32846-32853
6. Ma Y., and Hendershot L.M. Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways. J. Biol. Chem. 279 (2004) 13792-13799
7. 2+ homeostasis and mitochondrial function during endoplasmic reticulum stress. J. Biol. Chem. 279 (2004) 28733-28743
8. Yi P., Melnyk S., Pogribna M., Pogribny I.P., Hine R.J., and James S.J. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J. Biol. Chem. 275 (2000) 29318-29323
9. Castro R., Rivera I., Struys E.A., Jansen E.E., Ravasco P., Camilo M.E., Blom H.J., Jakobs C., and Tavares de Almeida I. Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin. Chem. 49 (2003) 1292-1296
10. Bönsch D., Lenz B., Kornhuber J., and Bleich S. Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J. Neural Transm. 111 (2004) 1611-1616
11. Bönsch D., Lenz B., Kornhuber J., and Bleich S. DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. NeuroReport 16 (2005) 167-170
12. Bleich S., Lenz B., Ziegenbein M., Beutler S., Frieling H., Kornhuber J., and Bönsch D. Epigenetic DNA hypermethylation of the Herp gene promoter induces downregulation of its mRNA expression in patients with alcohol dependence. Alcohol., Clin. Exp. Res. 30 (2006) 587-591
13. Pogribny I., Yi P., and James S.J. A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem. Biophys. Res. Commun. 262 (1999) 624-628
14. Fuso A., Scarpa S., Grandoni F., Strom R., and Lucarelli M. A reassessment of semiquantitative analytical procedures for DNA methylation: comparison of bisulfite- and HpaII polymerase-chain-reaction-based methods. Anal. Biochem. 350 (2006) 24-31
15. Bönsch D., Reulbach U., Bayerlein K., Hillemacher T., Kornhuber J., and Bleich S. Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism. Biol. Psychiatry 56 (2004) 984-986
16. Cai Y., Zhang C., Nawa T., Aso T., Tanaka M., Oshiro S., Ichijo H., and Kitajima S. Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element. Blood 96 (2000) 2140-2148
17. Woo C.W., Siow Y.L., Pierce G.N., Choy P.C., Minuk G.Y., Mymin D., and K. O. Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors. Am. J. Physiol. Endocrinol. Metab. 288 (2005) 1002-1010
18. Outinen P.A., Sood S.K., Pfeifer S.I., Pamidi S., Podor T.J., Li J., Weitz J.I., and Austin R.C. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood 94 (1999) 959-967
19. Hori O., Ichinoda F., Yamaguchi A., Tamatani T., Taniguchi M., Koyama Y., Katayama T., Tohyama M., Stern D.M., Ozawa K., Kitao Y., and Ogawa S. Role of Herp in the endoplasmic reticulum stress response. Genes Cells 9 (2004) 457-469
20. Paschen W., and Frandsen A. Endoplasmic reticulum dysfunction-A common denominator for cell injury in acute and degenerative diseases of the brain?. J. Neurochem. 79 (2001) 719-725
21. Mattson M.P., and Guo Q. Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?. J. Neurosci. Res. 50 (1997) 505-513
22. Sai X., Kawamura Y., Kokame K., Yamaguchi H., Shiraishi H., Suzuki R., Suzuki T., Kawaichi M., Miyata T., Kitamura T., De Strooper B., Yanagisawa K., and Komano H. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J. Biol. Chem. 277 (2002) 12915-12920
23. Ryu E.J., Harding H.P., Angelastro J.M., Vitolo O.V., Ron D., and Greene L.A. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J. Neurosci. 22 (2002) 10690-10698
24. Kouroku Y., Fujita E., Jimbo A., Kikuchi T., Yamagata T., Momoi M.Y., Kominami E., Kuida K., Sakamaki K., Yonehara S., and Momoi T. Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum. Mol. Genet. 11 (2002) 1505-1515
25. Yamamoto K., Yoshida H., Kokame K., Kaufman R.J., and Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J. Biochem. 136 (2004) 343-350
26. Kokame K., Kato H., and Miyata T. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. J. Biol. Chem. 276 (2001) 9199-9205
27. Sato H., Nomura S., Maebara K., Sato K., Tamba M., and Bannai S. Transcriptional control of costine/glutamate transporter gene by amino acid deprivation. Biochem. Biophys. Res. Commun. 325 (2004) 109-116
28. Bruhat A., Averous J., Carraro V., Zhong C., Reimold A.M., Kilberg M.S., and Fafournoux P. Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagines synthetase genes in response to amino acid deprivation or activation of the unfolded protein response. J. Biol. Chem. 277 (2002) 48107-48114
29. McKeever M.P., Weir D.G., Molloy A., and Scott J.M. Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat. Clin. Sci. 81 (1991) 551-556