Dehydroepiandrosterone in the nucleus accumbens is associated with early onset of depressive-behavior: A study in an animal model of childhood depression

Neuroscience

Volumn 149, Issue 3, 2007, Pages 573-581

  Malkesman, O ^a   Shayit, M ^a   Genud, R ^a   Zangen, A ^b   Kinor, N ^a   Maayan, R ^c   Weizman, A ^c   Weller, A ^a   Yadid, G ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

animal models of depression; FSL rats; monoamines; neurosteroids

Indexed keywords

BRAIN MONOAMINE; PRASTERONE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CHILDHOOD; CONTROLLED STUDY; FEMALE; MAJOR DEPRESSION; MALE; NEUROENDOCRINOLOGY; NEWBORN; NONHUMAN; NUCLEUS ACCUMBENS; ONSET AGE; ONTOGENY; PRIORITY JOURNAL; RAT;

3,4-DIHYDROXYPHENYLACETIC ACID; AGE OF ONSET; ANIMALS; BIOGENIC MONOAMINES; CHILD; DEHYDROEPIANDROSTERONE; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DOPAMINE; FEMALE; HOMOVANILLIC ACID; HUMANS; HYDROXYINDOLEACETIC ACID; NUCLEUS ACCUMBENS; RATS; RATS, INBRED STRAINS; SEROTONIN; SEXUAL MATURATION;

EID: 35448934519     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.06.031     Document Type: Article

References (54)

1. Axelson D.A., and Birmaher B. Relation between anxiety and depressive disorders in childhood and adolescence. Depress Anxiety 14 (2001) 67-78
2. Bahls S.C. Depression in childhood and adolescence: clinical features. J Pediatr 78 (2002) 359-366
3. Birmaher B., Ryan N.D., Williamson D.E., Brent D.A., Kaufman J., Dahl R.E., Perel J., and Nelson B. Childhood and adolescent depression: A review of the past 10 years. Part I. J Am Acad Child Adolesc Psychiatry 35 (1996) 1427-1439
4. Breiter H.C., Gollub R.L., Weisskoff R.M., Kennedy D.N., Makris N., Berke J.D., Goodman J.M., Kantor H.L., Gastfriend D.R., Riorden J.P., Mathew R.T., Rosen B.R., and Hyman S.E. Acute effects of cocaine on human brain activity and emotion. Neuron 19 (1997) 591-611
5. Commissiong J.W. Monoamine metabolites: their relationship and lack of relationship to monoaminergic neuronal activity. Biochem Pharmacol 34 (1985) 1127-1131
6. Compagnone N.A., and Mellon S.H. Dehydroepiandrosterone: a potential signaling molecule for neocortical organization during development. Proc Natl Acad Sci U S A 95 8 (1998) 4678-4683
7. Costello E.J., Mustillo S., Erkanli A., Keeler G., and Angold A. Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry 60 (2003) 837-844
8. Delgado P.L. Depression: the case for a monoamine deficiency. J Clin Psychiatry 61 Suppl 6 (2000) 7-11
9. Delgado P.L., and Moreno F.A. Role of norepinephrine in depression. J Clin Psychiatry 61 Suppl 1 (2000) 5-12
10. 3H]paroxetine binding and serotonin content of rat brain: absence of changes following antidepressant treatments. Eur J Pharmacol 235 (1993) 137-142
11. Dremencov E., Gispan-Herman I., Rosenstein M., Mendelman A., Overstreet D.H., Zohar J., and Yadid G. The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Prog Neuropsychopharmacol Biol Psychiatry 28 1 (2004) 141-147
12. Dremencov E., Newman M.E., Kinor N., Blatman-Jan G., Schindler C.J., Overstreet D.H., and Yadid G. Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment. Neuropharmacology 48 1 (2005) 34-42
13. Elhwuegi A.S. Central monoamines and their role in major depression. Prog Neuropsychopharmacol Biol Psychiatry 28 (2004) 435-451
14. Golubchik P., Lewis M., Maayan R., Sever J., Strous R., and Weizman A. Neurosteroids in child and adolescent psychopathology. Eur Neuropsychopharmacol 17 3 (2007) 157-164
15. Goodyer I.M., Herbert J., Tamplin A., and Altham P.M. First-episode major depression in adolescents. Affective, cognitive and endocrine characteristics of risk status and predictors of onset. Br J Psychiatry 176 (2000) 142-149
16. Hayashi T., and Su T.P. Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs 18 5 (2004) 269-284
17. Hechter O., Grossman A., and Chatterton R.T.J. Relationship of dehydroepiandrosterone and cortisol in disease. Med Hypotheses 49 (1997) 85-91
18. Herbert J., Goodyear I.M., Altham P.M.E., Pearson J., Secher S.M., and Shiers H.M. Adrenal secretion and major depression in 8 to 16 year olds. II. Influence of comorbidity at presentation. Psychol Med 26 (1996) 257-263
19. Hsiao C.C. Difference in pre- and post-treatment plasma DHEA levels were significantly and positively correlated with difference in pre- and post-treatment Hamilton depression scores following successful therapy for major depression. Psychoneuroendocrinology 31 7 (2006) 839-846
20. Kaufman J., Martin A., King R.A., and Charney D. Are child-, adolescent-, and adult-onset depression one and the same disorder?. Biol Psychiatry 49 (2001) 980-1001
21. Keller M.B., Ryan N.D., Strober M., and Klein R.G. Efficacy of paroxetine in the treatment of adolescent major depression: A randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 40 (2001) 762-772
22. Koob G.F., Sanna P.P., and Bloom F.E. Neuroscience of addiction. Neuron 21 (1998) 467-476
23. Kovacs M. Presentation and course of major depressive disorder during childhood and later years of the life span. J Am Acad Child Adolesc Psychiatry 35 (1996) 705-715
24. Kye C., and Ryan N.D. Pharmacologic treatment of child and adolescent depression. Child Adolesc Clin North Am 4 (1995) 261-281
25. Lewinsohn P.M., Hops H., Roberts R.E., Seeley J.R., and Andrews J.A. Adolescent psychopathology: I. Prevalence and incidence of depression and other DSM-III-R disorders in high school students. J Abnorm Psychol 102 (1993) 133-144
26. Maayan R., Morad O., Dorfman P., Overstreet D.H., Weizman A., and Yadid G. The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression. Eur Neuropsychopharmacol 15 3 (2005) 253-262
27. Maayan R., Strous R.D., Abou-Kaoud M., and Weizman A. The effect of 17beta estradiol withdrawal on the level of brain and peripheral neurosteroids in ovariectomized rats. Neurosci Lett 384 1-2 (2005) 156-161
28. Malkesman M., Braw Y., Yadid G., Maayan R., Overstreet D.H., Shabat-Simon M., Kesner Y., Touati-Werner D., and Weller A. Two different putative genetic animal models of childhood depression. Biol Psychiatry 59 (2006) 17-23
29. Maurice T., Urani A., Phan V.L., and Romieu P. The interaction between neuroactive steroids and the sigma 1 receptor function: Behavioral consequences and therapeutic opportunities. Brain Res Rev 37 (2001) 116-132
30. Meltzer H.Y., and Lowy M.T. The serotonin hypothesis of depression. In: Meltzer H.Y., and Lowy M.T. (Eds). Psychopharmacology: The third generation of progress (1987), Raven, New York 513-526
31. Michael K.D., and Crowley S.L. How effective are treatments for child and adolescent depression?. A meta-analytic review. Clin Psychol Rev 22 (2002) 247-269
32. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., and Monteggia L.M. Neurobiology of depression. Neuron 34 (2002) 13-25
33. Overstreet D.H. The Flinders sensitive line rats: A genetic animal model of depression. Neurosci Biobehav Rev 17 (1993) 51-68
34. Overstreet D.H., Friedman E., Mathe A.A., and Yadid G. The Flinders sensitive line rat: a selectively bred putative animal model of depression. Neurosci Biobehav Rev 29 4-5 (2005) 739-759
35. Owens M., Overstreet D.H., Knight D.L., Rezvani A.H., Ritchie J.C., Bissette G., Janowsky D.S., and Nemeroff C.B. Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity. Neuropsychopharmacology 4 (1991) 87-94
36. Panksepp J. Affective neuroscience. The foundations of human and animal emotions (1998), Oxford University Press, New York
37. Parker N.P., Levin E.R., and Lifrak E.T. Evidence for adrenocortical adaptation to severe illness. J Clin Endocrinol Metab 5 (1985) 947-952
38. Piccinelli M., and Wilkinson G. Gender differences in depression. Br J Psychiatry 177 (2000) 486-492
39. Pineyro G., and Blier P. Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev 51 3 (1999) 533-591
40. Richardson L.P., and Katzenellenbogen R. Childhood and adolescent depression: the role of primary care providers in diagnosis and treatment. Curr Probl Pediatr Adolesc Health Care 35 1 (2005) 6-24
41. Schmidt P.J., Daly R.C., Bloch M., Smith M.J., Danaceau M.A., St Clair L.S., Murphy J.H., Haq N., and Rubinow D.R. Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiatry 62 2 (2005) 154-162
42. Serova L., Sabban E.L., Zangen A., Overstreet D.H., and Yadid G. Altered gene expression for catecholamine biosynthetic enzymes and stress response in rat genetic model of depression. Brain Res Mol Brain Res 63 (1998) 133-138
43. Shayit M., Yadid G., Overstreet D.H., and Weller A. 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression. Brain Res 980 (2003) 100-108
44. Stahl S.P. Essential psychopharmacology of depression and bipolar disorder (2001), Cambridge University Press, Cambridge, UK
45. Strous R.D., Maayan R., and Weizman A. The relevance of neurosteroids to clinical psychiatry: From the laboratory to the bedside. Eur Neuropsychopharmacol 16 3 (2006) 155-169
46. Svec F., and Porter J. The effect of dehydroepiandrosterone (DHEA) on Zucker rat food selection and hypothalamic neurotransmitters. Psychoneuroendocrinology 22 (1997) S57-S62
47. Vaidya V.A., and Duman R.S. Depression: emerging insights from neurobiology. Br Med Bull 57 (2001) 61-79
48. van Broekhoven F., and Verkes R.J. Neurosteroids in depression: a review. Psychopharmacology 165 2 (2003) 97-110
49. Wolkowitz O.M., and Reus V.I. Neurotransmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treatment of depression. World J Biol Psychiatry 4 3 (2003) 98-102
50. Yadid G., Nakash R., Deri I., Grin T., Kinor N., Gispan I., and Zangen A. Elucidation of the neurobiology of depression: Insights from a novel genetic animal model. Prog Neurobiol 62 (2000) 353-378
51. Zalsman G., Brent D.A., and Weersing V.R. Depressive disorders in childhood and adolescence: an overview: epidemiology, clinical manifestation and risk factors. Child Adolesc Psychiatry Clin North Am 15 4 (2006) 827-841
52. Zangen A., Overstreet D.H., and Yadid G. High serotonin and 5-hydroxyindoleactic acid levels in limbic brain regions in a rat model of depression: Normalization by chronic antidepressant treatment. J Neurochem 69 (1997) 2477-2483
53. Zangen A., Overstreet D.H., and Yadid G. Increased catecholamine levels in specific brain regions of a rat model of depression: normalization by chronic antidepressant treatment. Brain Res 824 (1999) 243-250
54. Zangen A., Nakash R., Overstreet D.H., and Yadid G. Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens. Psychopharmacology (Berlin) 155 (2001) 434-439