Plasma phytoestrogens are not altered by probiotic consumption in postmenopausal women with and without a history of breast cancer

Journal of Nutrition

Volumn 134, Issue 8, 2004, Pages 1998-2003

  Nettleton, Jennifer A ^a   Greany, Kristin A ^a   Thomas, William ^a   Wangen, Kerry E ^a   Adlercreutz, Herman ^b   Kurzer, Mindy S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Plasma isoflavones; Probiotic; Soy

Indexed keywords

EQUOL; FRUCTOSE OLIGOSACCHARIDE; GENISTEIN; ISOFLAVONE; PHYTOESTROGEN; PROBIOTIC AGENT; SOYBEAN PROTEIN;

ADULT; ANAMNESIS; ARTICLE; BIFIDOBACTERIUM LONGUM; BREAST CANCER; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COLONY FORMING UNIT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DRUG CAPSULE; DRUG RESEARCH; DRUG SCREENING; DRUG USE; FEMALE; HUMAN; HYPOTHESIS; LACTOBACILLUS ACIDOPHILUS; MILK; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; SOYBEAN;

BIFIDOBACTERIUM; BIFIDOBACTERIUM LONGUM; GLYCINE MAX; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS;

EID: 3543107867     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.8.1998     Document Type: Article

References (51)

1. Murphy, P. A., Song, T., Buseman, G., Barua, K., Beecher, G. R., Trainer, D. & Holden, J. (1999) Isoflavones in retail and institutional soy foods. J. Agric. Food Chem. 47: 2697-2704.
2. Setchell, K. D., Brown, N. M., Zimmer-Nechemias, L., Brashear, W. T., Wolfe, B. E., Kirschner, A. S. & Heubi, J. E. (2002) Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am. J. Clin. Nutr. 76: 447-453.
3. Rowland, J., Wiseman, H., Sanders, T., Adlercreutz, H. & Bowey, E. (1999) Metabolism of oestrogens and phytoestrogens: role of the gut microflora. Biochem. Soc. Trans. 27: 304-308.
4. Mallet, A. K. & Rowland, I. R. (1988) Factors affecting the gut microflora. In: Role of the Gut Flora in Toxicity and Cancer (Rowland, I. R., ed.). Academic Press, London, UK.
5. Xu, X., Duncan, A. M., Wangen, K. E. & Kurzer, M. S. (2000) Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol. Biomark. Prev. 9: 781-786.
6. Xu, X., Duncan, A. M., Merz, B. E. & Kurzer, M. S. (1998) Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol. Biomark. Prev. 7: 1101-1108.
7. Xu, X., Harris, K. S., Wang, H. J., Murphy, P. A. & Hendrich, S. (1995) Bioavailability of soybean isoflavones depends upon gut microflora in women. J. Nutr. 125: 2307-2315.
8. Kelly, G. E., Joannou, G. E., Reeder, A. Y., Nelson, C. & Waring, M. A. (1995) The variable metabolic response to dietary isoflavones in humans. Proc. Soc. Exp. Biol. Med. 208: 40-43.
9. Ingram, D., Sanders, K., Kolybaba, M. & Lopez, D. (1997) Case-control study of phyto-oestrogens and breast cancer. Lancet 350: 990-994.
10. Duncan, A. M., Merz-Demlow, B. E., Xu, X., Phipps, W. R. & Kurzer, M. S. (2000) Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer. Cancer Epidemiol. Biomark. Prev. 9: 581-586.
11. Setchell, K. D., Borriello, S. P., Hulme, P., Kirk, D. N. & Axelson, M. (1984) Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am. J. Clin. Nutr. 40: 569-578.
12. Axelson, M., Sjovall, J., Gustafsson, B. E. & Setchell, K. D. (1984) Soya-a dietary source of the non-steroidal oestrogen equol in man and animals. J. Endocrinol. 102: 49-56.
13. Bowey, E., Adlercreutz, H. & Rowland, I. (2003) Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem. Toxicol. 41: 631-636.
14. Lampe, J. W., Karr, S. C.,Hutchins, A. M. & Stavin, J. L. (1998) Urinary equol excretion with a soy challenge: influence of habitual diet. Proc. Soc. Exp. Biol. Med. 217: 335-339.
15. Lampe, J. W., Skor, H. E., Li, S., Wähälä, K., Howald, W. N. & Chen, C. (2001) Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women. J. Nutr. 131: 740-744.
16. Rowland, I. R., Wiseman, H., Sanders, T. A., Adlercreutz, H. & Bowey, E. A. (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr. Cancer 36: 27-32.
17. Kelly, G. E., Nelson, C., Waring, M. A., Joannou, G. E. & Reeder, A. Y. (1993) Metabolites of dietary (soya) isoflavones in human urine. Clin. Chim. Acta 223: 9-22.
18. Lampe, J. W., Gustafson, D. R., Hutchins, A. M., Martini, M. C., Li, S., Wähälä, K., Grandits, G. A., Potter, J. D. & Slavin, J. L. (1999) Urinary isoflavonoid and lignan excretion on a Western diet: relation to soy, vegetable, and fruit intake. Cancer Epidemiol. Biomark. Prev. 8: 699-707.
19. Adlercreutz, H., Honjo, H., Higashi, A., Fotsis, T., Hamalainen, E., Hasegawa, T. & Okada, H. (1991) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am. J. Clin. Nutr. 54: 1093-1100.
20. Sanders, M. E. & Huis in't Veld, J. (1999) Bringing a probiotic-containing functional food to the market: microbiological, product, regulatory and labeling issues. Antonie Leeuwenhoek 76: 293-315.
21. Goldin, B. R. & Gorbach, S. L. (1984) Alterations of the intestinal microflora by diet, oral antibiotics, and Lactobacillus: decreased production of free amines from aromatic nitro compouhds, azo dyes, and glucuronides. J. Natl. Cancer Inst. 73: 689-695.
22. Cole, C., Fuller, R. & Carter, S. (1989) Effect of probiotic supplements of Lactobacillus acidophilus and Bifdobacterium adlescentis 2204 on beta-glucosidase and beta-glucuronidase activity in the lower gut of rats associated with a human faecal flora. Microb. Ecol. Health Dis. 2: 223-225.
23. Ling, W. H., Korpela, R., Mykkanen, H., Salminen, S. & Hanninen, O. (1994) Lactobacillus strain GG supplementation decreases colonic hydrolytic and reductive enzyme activities in healthy female adults. J. Nutr. 124: 18-23.
24. Goldin, B. R. & Gorbach, S. L. (1984) The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity. Am. J. Clin. Nutr. 39: 756-761.
25. Marteau, P., Pochart, P., Flourie, B., Pellier, P., Santos, L., Desjeux, J. F. & Rambaud, J. C. (1990) Effect of chronic ingestion of a fermented dairy product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities of the colonic flora in humans. Am. J. Clin. Nutr. 52: 685-688.
26. Hur, H. G., Lay, J. O., Jr., Beger, R. D., Freeman, J. P. & Rafii, F. (2000) Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin. Arch. Microbiol. 174: 422-428.
27. Forestier, C., Champs, C. D., Vatoux, C. & Joly, B. (2001) Probiotic activities of Lactobacillus casei rhamnosus: in vitro adherence to intestinal cells and antimicrobial properties. Res. Microbiol. 152: 167-173.
28. Fujiwara, S., Seto, Y., Kumura, A. & Hashiba, H. (2001) Intestinal transit of an orally administered streptomycin-rifampicin-resistant variant of Bifidobacterium longum SBT2928: its long-term survival and effect on the intestinal microflora and metabolism. J. Appl. Microbiol. 90: 43-52.
29. Saito, Y., Hamanka, Y., Saito, K., Takizawa, S. & Benno, Y. (2002) Stability of species composition of fecal bifidobacteria in human subjects during fermented milk administration. Curr. Microbiol. 44: 368-373.
30. Winter, J., Moore, L. H., Dowell, V. R., Jr. & Bokkenheuser, V. D. (1989) C-ring cleavage of flavonoids by human intestinal bacteria. Appl. Environ. Microbiol. 55: 1203-1208.
31. Hur, H. G., Beger, R. D., Heinze, T. M., Lay, J. O., Jr., Freeman, J. P., Dore, J. & Rafii, F. (2002) Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein. Arch. Microbiol. 178: 8-12.
32. Durnin, J. V. & Womersley, J. (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br. J. Nutr. 32: 77-97.
33. Brouwers, E., L'Homme, R., Al-Maharik, N., Lapcik, O., Hampl, R., Wähälä K., Mikola, H. & Adlercreutz, H. (2003) Time-resolved fluoroimmunoassay for equol in plasma and urine. J. Steroid Biochem. Mol. Biol. 84: 577-588.
34. L'Homme, R., Brouwers, E. Al-Maharik, N., Lapcik, O., Hampl, R., Mikola, H., Wähälä, K. & Adlercreutz, H. (2002) Time-resolved fluoroimmunoassay of plasma and urine O-desmethylangolensin. J. Steroid Biochem. Mol. Biol. 81: 353-361.
35. Wang, G. J., Lapcik, O., Hampl, R., Uehara, M., Al-Maharik, N., Stumpf, K., Mikola, H., Wähälä, K. & Adlercreutz, H. (2000) Time-resolved fluoroimmunoassay of plasma daidzein and genistein. Steroids 65: 339-348.
36. Stumpf, K., Uehara, M., Nurmi, T. & Adlercreutz, H. (2000) Changes in the time-resolved fluoroimmunoassay of plasma enterolactone. Anal. Biochem. 284: 153-157.
37. Adlercreutz, H., Wang, G. J., Lapcik, O., Hampl, R., Wähä lä, K., Makela, T., Lusa, K., Taime, M. & Mikola, H. (1998) Time-resolved fluoroimmunoassay for plasma enterolactone. Anal. Biochem. 265: 208-215.
38. SAS Institute Inc. (2001) Statistical Analysis Systems, 8.2 ed. SAS Institute, Cary, NC.
39. Zheng, W., Dai, Q., Custer, L. J., Shu, X. O., Wen, W. Q., Jin, F. & Franke, A. A. (1999) Urinary excretion of isoflavonoids and the risk of breast cancer. Cancer Epidemiol. Biomark. Prev. 8: 35-40.
40. Murkies, A., Dalais, F. S., Briganti, E. M., Burger, H. G., Healy, D. L., Wahlqvist, M. L. & Davis, S. R. (2000) Phytoestrogens and breast cancer in postmenopausal women: a case control study. Menopause 7: 289-296.
41. Dai, Q., Franke, A. A., Jin, F., Shu, X. O., Hebert, J. R., Custer, L. J., Cheng, J., Gao, Y. T. & Zheng, W. (2002) Urinary Excretion of Phytoestrogens and Risk of Breast Cancer among Chinese Women in Shanghai. Cancer Epidemiol. Biomark. Prev. 11: 815-821.
42. den Tonkelaar, I., Keinan-Boker, L., Veer, P. V., Arts, C. J., Adlercreutz, H., Thijssen, J. H. & Peeters, P. H. (2001) Urinary phytoestrogens and postmenopausal breast cancer risk. Cancer Epidemiol. Biomark. Prev. 10: 223-228.
43. Adlercreutz, H., Fotsis, T., Heikkinen, R., Dwyer, J. T., Woods, M., Goldin, B. R. & Gorbach, S. L. (1982) Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet 2: 1295-1299.
44. Hutchins, A. M., Slavin, J. L. & Lampe, J. W. (1995) Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. J. Am. Diet Assoc. 95: 545-551.
45. Setchell, K. D., Brown, N. M. & Lydeking-Olsen, E. (2002) The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones, J. Nutr. 132: 3577-3584.
46. Day, A. J., DuPont, M. S., Ridley, S., Rhodes, M., Rhodes, M. J., Morgan, M. R. & Williamson, G. (1998) Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett. 436: 71-75.
47. Chang, Y. C. & Nair, M. G. (1995) Metabolism of daidzein and genistein by intestinal bacteria. J. Nat. Prod. 58: 1892-1896.
48. Schoefer, L., Mohan, R., Braune, A., Birringer, M. & Blaut, M. (2002) Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol. Lett. 208: 197-202,
49. Ueno, T., Uchiyama, S. & Nikuchi, N. (2001) The role of intestinal bacteria on biological effects of soy isoflavones in humans. Fourth International Symposium on the Role of Soy in Treating and Preventing Chronic Disease, San Diego, GA.
50. Atkinson, C., Berman, S., Humbert, O. & Lampe, J. W. (2004) In vitro incubation of human feces with daidzein and antibiotics suggests interindividual differences in the bacteria responsible for equol production. J. Nutr. 134: 596-599.
51. Setchell, K. D., Brown, N. M., Desai, P., Zimmer-Nechemias, L., Wolfe, B. E., Brashear, W. T., Kirschner, A. S., Cassidy, A. & Heubi, J. E. (2001) Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J. Nutr. 131: 1362S-1375S.