In Vitro Incubation of Human Feces with Daidzein and Antibiotics Suggests Interindividual Differences in the Bacteria Responsible for Equol Production

Journal of Nutrition

Volumn 134, Issue 3, 2004, Pages 596-599

  Atkinson, Charlotte ^a   Berman, Sheryl ^b   Humbert, Olivier ^a   Lempe, Johanna W ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b BASTYR UNIVERSITY   (United States)

Author keywords

Antibiotic; Bacteria; Equol; Isoflavone; Soy

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CHLORAMPHENICOL; COLISTIN; DAIDZEIN; DIHYDRODAIDZEIN; EQUOL; ERYTHROMYCIN; ISOFLAVONE DERIVATIVE; KANAMYCIN; METRONIDAZOLE; O NORANGOLENSIN; PENICILLIN G; RIFAMPICIN; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANAEROBIC BACTERIUM; ANIMAL TESTING REDUCTION; ARTICLE; BACTERIAL METABOLISM; CANCER PREVENTION; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE MODEL; FECES ANALYSIS; HUMAN; INTESTINE FLORA; NONHUMAN; PROTECTION; REACTION ANALYSIS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 1542376914     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.3.596     Document Type: Article

References (22)

1. Lampe, J. W., Skor, H. E., Li, S., Wähälä, K., Howald, W. N. & Chen, C. (2001) Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women. J. Nutr. 131: 740-744.
2. Rowland, I. R., Wisemen, H., Sanders, T.A.B., Adlercreutz, H. & Bowey, E. A. (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr. Cancer 36: 27-32.
3. Setchell, K. D., Brown, N. M. & Lydeking-Olsen, E. (2002) The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J. Nutr. 132: 3577-3584.
4. Arai, Y., Uehara, M., Sato, Y., Kimira, M., Eboshida, A., Adlercreutz, H. & Watanabe, S. (2000) Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J. Epidemiol. 10: 127-135.
5. Kelly, G. E., Joannou, G. E., Reeder, A. Y., Nelson, C. & Waring, M. A. (1995) The variable metabolic response to dietary isoflavones in humans. Proc. Soc. Exp. Biol. Med. 208: 40-43.
6. Duncan, A. M., Merz-Demlow, B. E., Xu, X., Phipps, W. R. & Kurzer, M. S. (2000) Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 9: 581-586.
7. Ingram, D., Sanders, K., Kolybaba, M. & Lopez, D. (1997) Case-control study of phyto-oestrogens and breast cancer. Lancet 350: 990-994.
8. Cassidy, A., Bingham, S. & Setchell, K.D.R. (1994) Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am. J. Clin. Nutr. 60: 333-340.
9. Adlercreutz, H., Hockerstedt, K., Bannwart, C., Bloigu, S., Hämäläinen, E., Fotsis, T. & Ollus, A. (1987) Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J. Steroid Biochem. 27: 1135-1144.
10. Cruz, M.L.A., Wong, W. W., Mimouni, F., Hachey, D. L., Setchell, K.D.R., Klein, P. D. & Tsang, R. C. (1994) Effects of infant nutrition on cholesterol synthesis rates. Pediatr. Res. 35: 135-140.
11. Rowland, I., Wiseman, H., Sanders, T., Adlercreutz, H. & Bowey, E. (1999) Metabolism of oestrogens and phytoestrogens: role of the gut microflora. Biochem. Soc. Trans. 27: 304-308.
12. Bowey, E., Adlercreutz, H. & Rowland, I. (2003) Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem. Toxicol. 41: 631-636.
13. Chang, Y.-C. & Nair, M. G. (1995) Metabolism of daidzein and genistein by intestinal bacteria. J. Nat. Prod. 58: 1892-1896.
14. Setchell, K.D.R., Bordello, S. P., Hulme, P., Kirk, D. N. & Axelson, M. (1984) Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am. J. Clin. Nutr. 40: 569-578.
15. Setchell, K. D. & Cassidy, A. (1999) Dietary isoflavones: biological effects and relevance to human health. J. Nutr. 129: 758S-767S.
16. Atkinson, C., Skor, H. E., Fitzgibbons, E. D., Scholes, D., Chen, C., Wähälä, K., Schwartz, S. M. & Lampe, J. W. (2002) Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake. Cancer Epidemiol. Biomark. Prev. 11: 253-260.
17. Kucers, A., Crowe, S. M., Grayson, M. L. & Hoy, J. F. (1997) The Use of Antibiotics. A Clincal Review of Antibacterial, Antifungal and Antiviral Drugs, 5th ed. Butterworth-Heinemann, Boston, MA.
18. Hur, H. G., Lay, J. O., Jr., Beger, R. D., Freeman, J. P. & Rafii, F. (2000) Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin. Arch. Microbiol. 174: 422-428.
19. Rafii, F., Davis, C., Park, M., Heinze, T. M. & Beger, R. D. (2003) Variations in metabolism of the soy isoflavonoid daidzein by human intestinal microfloras from different individuals. Arch. Microbiol. 180: 11-16.
20. Xu, X., Harris, K. S., Wang, H.-J., Murphy, P. & Hendrich, S. (1995) Bioavailability of soybean isoflavones depends upon gut microflora in women. J. Nutr. 125: 2307-2315.
21. Reese, R. E. & Betts, R. F. (1993) Handbook of Antibiotics, 2nd ed. Little, Brown, Boston, MA.
22. Blair, R. M., Appt, S. E., Franke, A. A. & Clarkson, T. B. (2003) Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis). J. Nutr. 133: 2262-2267.