Nucleosomes bind fibroblast growth factor-2 for increased angiogenesis in vitro and in vivo

Molecular Cancer Research

Volumn 2, Issue 5, 2004, Pages 281-288

  Tanner, Jerome E ^a,c   Forté, André ^a   Panchal, Chandra ^b  

^a Lab Anti Nucleosome Antibody Ther   (Canada)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c TanTec Biosystems Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; HEMOGLOBIN; HEPARAN; HEPARIN; HEPARIN BINDING PROTEIN; MATRIGEL; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL DEATH; CELL MIGRATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METASTASIS; NUCLEOSOME; PRIORITY JOURNAL; SOLID TUMOR; TUMOR NECROSIS; TUMOR VASCULARIZATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; FIBROBLAST GROWTH FACTOR 2; HEPARIN; HUMANS; LAMININ; MICE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; NUCLEOSOMES; PROTEIN BINDING; PROTEOGLYCANS; UMBILICAL CORD;

EID: 3543072976     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Zetter BR. Angiogenesis and tumor metastasis. Annu Rev Med 1998;49:407-24.
2. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-64.
3. Parangi S, O'Reilly M, Christofori G, et al. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci USA 1996; 93:2002-7.
4. Vaupel P, Kallowski F, Okunieff P. Blood flow, oxygen consumption and tissue oxygenation of human tumors. Adv Exp Med Biol 1990;277:895-905.
5. Soini Y, Pääkkö P, Lehto V-P. Histopathological evaluation of apoptosis in cancer. Am J Pathol 1998;53:1041-53.
6. Formigli L, Papucci L, Tani A, et al. Aponecrosis: morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis. J Cell Physiol 2000;182:41-9.
7. Lichtenstein AV, Melkonyan HS, Tomei LD, Umansky SR. Circulating nucleic acids and apoptosis. Ann NY Acad Sci 2001;945:239-49.
8. Hotdenrieder S, Stieber P, Bodenmuller H, et al. Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer 2001;95:114-20.
9. Burlingame RW, Love WE, Wang BC, Hamlin R, Nguyen HX, Moudrianakis EN. Crystallographic structure of the octameric historic core of the nucleosome at a resolution of 3.3 A. Science 1985;228:546-53.
10. Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 2001;12:375-91.
11. Kunz M, Hartmann A, Flory E, et al. Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. Am J Pathol 1999;155:753-63.
12. Klagsbrun M, Moses MA. Molecular angiogenesis. Chem Biol 1999;6:R217-24.
13. Iozzo RV, San Antonio JD. Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena. J Clin Invest 2001;108:349-55.
14. Ornitz DM, Yayon A, Flanagan JG, Svahn CM, Levi E, Leder P. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol Cell Biol 1992;12:240-7.
15. Miralem T, Steinberg R, Price D, Avraham H. VEGF(165) requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells. Oncogene 2001;20:5511-24.
16. Folkman J, Shing Y. Control of angiogenesis by heparin and other sulfated polysaccharides. Adv Exp Med Biol 1992;313:355-64.
17. Nugent MA, Iozzo RV. Fibroblast growth factor-2. Int J Biochem Cell Biol 2000;32:115-20.
18. Hileman RE, Fromm JR, Weiler JM, Linhardt RJ. Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins. Bioessays 1998;20:156-67.
19. Fusetti L, Pruneri G, Gobbi A, et al. Human myeloid and lymphoid malignancies in the non-obese diabetic/severe combined immunodeficiency mouse model: frequency of apoptotic cells in solid tumors and efficiency and speed of engraftment correlate with vascular endothelial growth factor production. Cancer Res 2000;60:2527-34.
20. Sharma V, Knobloch TJ, Benjamin D. Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines. Biochem Biophys Res Commun 1995;208:704-13.
21. Gospodarowica G, Cheng J. Heparin protects basic and acidic FGF from inactivation. J Cell Physiol 1986;128:475-84.
22. Kajio T, Kawahara K, Kato K. Quantitative colorometric assay for basic fibroblast growth factor using bovine endothelial cells and heparin. J Pharmacol Toxicol Methods 1992;28:9-15.
23. McKeehan WL, Wu X, Kan M. Requirement for anticoagulant heparin sulfate in the fibroblast growth factor receptor complex. J Biol Chem 1999; 274:21511-4.
24. Lynch CC, Matrisian LM. Matrix metalloproteinases in tumor-host cell communication. Differentiation 2002;70:561-73.
25. Seppa ST, Seppa HE, Liotta LA, Glaser BM, Martin GR, Schiffmann E. Cultured tumor cells produce chemotactic factors specific for endothelial cells: a possible mechanism for tumor-induced angiogenesis. Invasion Metastasis 1983;3:139-50.
26. Glaser BM, D'Amore PA, Seppa H, Seppa S, Schiffmann E. Adult tissues contain chemoattractants for vascular endothelial cells. Nature 1980;288:483-4.
27. Malinda KM, Sidhu GS, Mani H, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol 1999;113:364-8.
28. 1 stimulates endothelial cell migration, angiogenesis and wound healing. J Immunol 1998; 160:1001-6.
29. Akhtar N, Dickerson EB, Auerbach R. The sponge/Matrigel angiogenesis assay. Angiogenesis 2002;5:75-80.
30. Salcedo R, Ponce ML, Young HA, et al. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 2000;96:34-40.
31. Robertson NE, Discafani CM, Downs EC, et al. A quantitative in vivo mouse model used to assay inhibitors of tumor-induced angiogenesis. Cancer Res 1991; 51:1339-44.
32. Passaniti A, Taylor RM, Pili R, et al. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 1992;67:519-28.
33. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407:249-57.
34. Matter A. Tumor angiogenesis as a therapeutic target. Drug Discov Today 2001;6:1005-24.
35. Tanner JE. Nucleosomes activate NF-κB in endothelial cells for the induction of the pro-angiogenic cytokine interleukin-8 (IL-8). Int J Cancer. In press.
36. Hefeneider SH, Cornell KA, Brown LE, Bakke AC, McCoy SL, Bennett RM. Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin Immunol Immunopathol 1992;63:245-51.
37. Rosen EM, Liu D, Setter E, Bhargava M, Goldberg ID. Interleukin-6 stimulates motility of vascular endothelium. EXS 1991;59:194-205.
38. Motro B, Itin A, Sachs L, Keshet E. Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci USA 1990;87:3092-6.
39. Lil A, Dubey S, Varney ML, Dave BJ, Singh RK. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 2003;170:3369-76.
40. Kajo T, Kawahara K, Kato K. Stabilization of basic fibroblast growth factor with dextran sulfate. FEBS Lett 1992;306:243-6.
41. Dauchel MC, Courty J, Barritault MD. Modulation of mitogenic activity and cellular binding of basic fibroblast growth factor by basic proteins. J Cell Biochem 1989;39:411-20.
42. Sudhalter J, Folkman J, Svahn CM, Bergendal K, D'Amore PA. Importance of size, sulfation, and anticoagulant activity in the potentiation of acidic fibroblast growth factor by heparin. J Biol Chem 1989;264:6892-7.
43. Powers CJ, McLeskey SW, Wellstein A. Fibroblast growth factors, their receptors and signaling, Endocr Relat Cancer 2000;7:165-97.
44. Kramer M, Sachsenmaier C, Herrlich P, Rahmsdorf HJ. UV Irradiation-induced Interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response. J Biol Chem 1993;268:6734-41.
45. McNeil PL, Muthukrishnan L, Warder E, D'Amore PA. Growth factors are released by mechanically wounded endothelial cells. J Cell Biol 1989;109:811-22.
46. Yager TD, McMurray CT, van Holde KE. Salt-induced release of DNA from nucleosome core particles. Biochemistry 1989;28:2271-81.
47. Iakoubov LZ, Torchilin VP. A novel class of antitumor antibodies: nucleosome-restricted antinuclear autoantibodies (ANA) from healthy aged nonautoimmune mice. Oncol Res 1997;9:439-46.
48. Bernard-Pierrot I, Delbe J, Caruelle D, Barritault D, Courty J, Milhiet PE. The lysine-rich C-terminal tail of heparin affin regulatory peptide is required for mitogenic and tumor formation activities. J Biol Chem 2001;276:12228-34.