A novel class of antitumor antibodies: nucleosome-restricted antinuclear autoantibodies (ana) from healthy aged nonautoimmune mice

Oncology Research

Volumn 9, Issue 8, 1997, Pages 439-446

  Lakoubov, Leonid Z ^a,b   Torchilin, Vladimir P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aging; Antinuclear autoantibody; Cancer therapy; Monoclonal antibody; Nucleosome; Tumor cell surface

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINUCLEAR ANTIBODY; AUTOANTIGEN; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

AGING; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY SPECIFICITY; ARTICLE; C57BL MOUSE; EXPERIMENTAL MELANOMA; FEMALE; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; NUCLEOSOME; T CELL LYMPHOMA;

AGING; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; AUTOANTIGENS; FEMALE; LYMPHOMA, T-CELL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NUCLEOSOMES;

EID: 0031308829     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Jurcic, J. G.; Scheinberg, D. A.; Houghton, A. N. Monoclonal antibody therapy of cancer. Cancer Chemother. Biol. Response Modif. 16:168-88; 1996.
2. Jain, R. K. Barriers to drug delivery in solid tumors. Sci. Am. 271:58-65; 1994.
3. Colnaghi, M. I.; Menard, S.; Delia Porta, G. Natural antitumor serum reactivity in BALB/c mice. II. Control by regulator T-cells. Int. J. Cancer 19:275-280; 1977.
4. Chow, D. A.; Wolosin, L. B.; Greenberg, A. H. Murine natural anti-tumor antibodies. II. The contribution of natural antibodies to tumor surveillance. Int. J. Cancer 27:459-469; 1981.
5. Kerstin, D.; Ollert, M. W.; Juhl, H.; Vollmert, C.; Erttmann, R.; Vogel, C.-W.; Bredehost, R. Growth arrest of solid human neuroblastoma xenografts in nude rats by natural IgM from healthy humans. Nature Med. 2:686-689; 1996.
6. lakoubov, L. Z.; Rokhlin, O. W.; Torchilin, V. P. Antinuclear autoantibodies of the aged reactive against the surface of tumor but not normal cells. Immunol. Lett. 47:147-149; 1995.
7. Globerson, A.; Tomer, Y.; Shoefeld, Y. Aging, natural autoantibodies, and autoimmunity. In: Shoenfeld, Y.; Isenberg, D. A., cds. Natural autoantibodies. Boca Raton, FL: CRC Press; 1993:60-79.
8. Xavier, R. M.; Yamauchi, Y.; Nakamura, M.; Tanigawa, Y.; Ishikura, H.; Tsunematsu, T.; Kobayashi, S. Antinuclear antibodies in healthy aging people: A prospective study. Mech. Ageing Dev. 78:145-154; 1995.
9. lakoubov, L. Z.; Mongayt, D. A.; Torchilin, V. P. Monoclonal anti-nuclear autoantibody from the aged effectively suppresses tumor development in vivo. Cancer Biother. Radiopharm. 8:299-310; 1995.
10. Sakharova, A. V.; lakoubov, L. Z.; Grivennikov, I. A.; Romanova, N. V.; Lobazina, N. Yu. Ontogenetic changes in the spectrum of specificities of natural monoclonal autoantibodies reacting with nerve tissue antigens. Zh. Obshch. Biol. 47: 625-630; 1986.
11. Ibraghimov, A. R.; Lynch, R. G. Heterogeneity and biased T cell receptor alpha/beta repertoire of mucosal CD8+ cells from murine large intestine: Implications for functional state. J. Exp. Med. 180:433-444; 1994.
12. LeLann, A. D.; Fournie, G. J.; Boissier, L.; Toutain, P. L.; Benoist, H. In vitro inhibition of natural-killer-mediated lysis by chromatin fragments. Cancer Immunol. Immunother. 39: 185-192; 1994.
13. Tan, E. M. Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44:93-151; 1989.
14. Losman, J. A.; Fasy, T. M.; Novick, K. E.; Massa, M.; Monestier, M. Nudeosome-specific antibody from an autoimmune MRL/Mp-lpr/Ipr mouse. Arthritis Rheum. 36:552-560; 1993.
15. Siegel, S. Nonparametric statistics for the behavioral sciences. New York: McGraw-Hill Book Company; 1956.
16. Avrameas, S. Natural autoantibodies: from "horror autotoxicus" to "gnothi seauton." Immunol. Today 12:154-156; 1991.
17. Mohan, C.; Adams, S.; Stanik, V.; Datta, S. K. Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus. J.Exp. Med. 177:1367-1381; 1993.
18. Amoura, Z.; Chabre, H.; Koutouzov, S.; Lotton, C.; Cabres-
19. pines, A.; Bach, J. F.; Jacob, L. Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp Ipr/Ipr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria. Arthritis Rheum. 37:1684-1688; 1994.
20. Raz, E.; Ben-Bassat, H.; Davidi, T.; Shlomai, Z.; Eilat, D. Cross-reactions of anti-DNA autoantibodies with cell surface proteins. Eur. J. Immunol. 23:383-390; 1993.
21. Watson, K.; Edwards, R. J.; Shaunak, S.; Gooderham, N. J.; Davies, D. S. Nucleosomes isolated from the cell surface. 3rd Conf. on Retro, and Opportun. Infect.; 1996:70.
22. Adolph, K. W.; Cheng, S. M.; Laemmli, U. K. Role of nonhistone proteins in metaphase chromosome structure. Cell 12: 805-816; 1977.
23. Jacob, L.; Viard, J.-P.; Allenet, B.; Anin, M.-F.; Slama, F. B. H.; Vanderkerckhove, J.; Primo, J.; Markovits, J.; Jacob, F.; Bach, J. F.; Le Pecq, J.-B.; Louvard, D. A monoclonal anti-double-stranded DNA autoantibody binds to a 94-kDa cell-surface protein on various cell types via nucleosomes or a DNA-histone complex. Proc. Natl. Acad. Sci. USA 86:46694673; 1989.
24. Koutouzov, S.; Cabrespines, A.; Amoura, A.; Chabre, H.; Lotton, C.; Bach, J.-F. Binding of nucleosomes to a cell surface receptor: Redistribution and endocytosis in the presence of lupus antibodies. Eur. J. Immunol. 26:472-486; 1996.
25. Emlen, W.; Holers, V. M.; Arend, W. P.; Kotzin, B. Regulation of nuclear antigen expression on the cell surface of human monocytes. J. Immunol. 148:3042-3048; 1992.
26. Hefeneider, S. H.; Cornell, K. A.; Brown, L. E.; Bakke, A. C.; McCoy, S. L.; Bennet, R. M. Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin. Immunol. Immunopathol. 63:245251; 1992.
27. Rekvig, O. P.; Hannestad, K. Properties of antinuclear antibodies that cross-react with plasma membranes. Scand. J. Immunol. 9:325-332; 1979.
28. Mecheri, S.; Dannecker, G.; Dennig, D.; Poncet, P.; Hoffman, M. K. Anti-histone autoantibodies react specifically with the B cell surface. Mol. Immunol. 30:549-557; 1992.
29. Klajman, A.; Kafri, B.; Shohat, T.; Drucker, I.; Moalem, T.; Jaretzky, A. The prevalence of antibodies to histones induced by procainamide in old people, in cancer patients, and in rheumatoid-Iike disease. Clin. Immunol. Immunopathol. 27:1-8; 1983.
30. Imai, H.; Nakano, Y.; Kiyosawa, K.; Tan, E. M. Increasing titers and changing specificities of antinuclear antibodies in patients with chronic liver disease who develop hepatocellular carcinoma. Cancer 71:26-35; 1993.
31. Fournie, G. J.; Courtin, J. P.; Lavai, F.; Châle, J. J.; Pourrat, J. P.; Pujazon, M. C.; Lauque, D.; Charles. P. Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours. Cancer Lett. 91:221-227; 1995.
32. Burlingame, R. W.; Rubin, R. L.; Balderas, R. S.; Theophilopoulos, A. N. Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. J.Clin. Invest. 91:1687-1696; 1993.
33. Garrido, F.; Cabrera, T.; Lopez-Nevot, M. A.; Ruiz-Cabello, F. HLA class I antigens in human tumors. Adv. Cancer Res. 67:155-195; 1995.