Thymosin α1 stimulates endothelial cell migration, angiogenesis, and wound healing

Journal of Immunology

Volumn 160, Issue 2, 1998, Pages 1001-1006

  Malinda, Katherine M ^a   Sidhu, Gurmel S ^b   Banaudha, Krishna K ^b   Gaddipati, Jaya P ^b   Maheshwari, Radha K ^b   Goldstein, Allan L ^c   Kleinman, Hynda K ^a,d  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; THYMOSIN ALPHA1;

AMINO ACID SEQUENCE; ANGIOGENESIS; ARTICLE; CELL CULTURE; CELL MIGRATION; CELL REGENERATION; EXTRACELLULAR MATRIX; FIBROBLAST; HEPATITIS VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOMODULATION; LYMPHOID CELL; MACROPHAGE FUNCTION; PRIORITY JOURNAL; WOUND HEALING;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, TOPICAL; AMINO ACID SEQUENCE; ANIMALS; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; THYMOSIN; UMBILICAL VEINS; WOUND HEALING;

EID: 0031985414     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Grant, D. S., J. L. Kinsella, M. C. Kibbey, S. LaFlamme, P. D. Burbelo, A. L. Goldstein, and H. K. Kleinman. 1995. Matrigel induces thymosin β4 gene in differentiating endothelial cells. J. Cell Sci. 108:3685.
2. 4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J. 11:474.
3. Low, T. L. K., G. B. Thurman, M. McAdoo, J. E. McClure, J. L. Rossio, P. H. Naylor, and A. L. Goldstein. 1979. The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha-1 and polypeptide b1 from calf thymus. J. Biol. Chem. 254:981.
4. 1: chemistry, mechanism of action and clinical applications. In: Combination Therapies 2. A. L. Goldstein and E. Garaci, eds. Plenum Press, New York: 39.
5. 1. Cancer Invest. Cancer Invest. 12:545.
6. Andreone, P., C. Cursaro, A. Gramenzi, C. Zavaglia, I. Rezakovic, E. Altomare, R. Severini, J. S. Franzone, O. Albano, G. Ideo, M. Bernardi, and G. Gasbarrini. 1996. A randomized control trial of thymosin a, versus interferon alpha treatment in patients with hepatitis B antigen antibody and hepatitis B virus DNA-positive chronic hepatitis B. Hepatology 24:774.
7. 1 therapy in the treatment of chronic hepatitis B. J. Viral Hepatitis 3:191.
8. Sherman, K. E., M. H. Sjogren, R. L. Creager, S. Freeman, S. Lewey, S. Root, D. Davis, F. L. Weber, K. Ishak, and Z. D. Goodman. 1996. Thymosin alpha-1 + interferon combination therapy for chronic hepatitis C: results of a randomized controlled trial. Hepatology 24:402A.
9. 1. J. Immunoassay 17:85.
10. Oates, K. and A. L. Goldstein. 1995. Thymosin. In: Biological therapy of cancer. V. T. DeVita, S. Hellman and S. A. Rosenberg, eds. J. B. Lippincott Co., PA. p. 841.
11. Serrate, S. A., R. S. Schulof, L. Leondaridis, A. L. Goldstein, and M. B. Sztein. 1987. Modulation of human natural killer cell cytotoxic activity, lymphokine production and interleukin 2 receptor expression by thymic hormones. J. Immunol. 139:2338.
12. Hu., S. K., T. L. K. Low, and A. L. Goldstein. 1981. Modulation of terminal deoxynucleotidyl transferase activity by thymosin. Mol. Cell. Biochem. 41:49.
13. 1 antagonism of induced apoptosis of developing thymocytes in vitro. Mol. Biol. Cell 6S:356a.
14. Sburlati, A. R., R. E. Manrow, and S. L. Berger. 1991. Prothymosin α antisense oligomers inhibit myeloma cell division. Proc. Natl. Acad. Sci. USA 88:253.
15. 1 and epidermal growth factor in stimulation of rat fibroblast cell proliferation: cellular and molecular aspects. Cell. Physiol. Biochem. 2:69.
16. Moody, T. W., M. Faragasan, F. Zia, M. Cesnjaj, and A. L. Goldstein. 1993. Thymosin alpha 1 down regulates the growth of human non-small cell lung cancer. Cancer Res. 53:5214.
17. Jaffe, E. A., R. L. Nachman, C. G. Becker, and C. R. Minick. 1973. Culture of endothelial cells derived from umbilical veins: identification by morphological and immunological criteria. J. Clin. Invest. 52:2745.
18. Kibbey, M. C., M. L. Corcoran, L. M. Wahl, and H. K. Kleinman. 1994. Laminin SIKVAV peptide-induced angiogenesis in vivo is potentiated by neutrophils. J. Cell Phys. 160:185.
19. Grant, D. S., J. L. Kinsella, R. Fridman, R. Auerbach, B. A. Piasecki, Y. Yamada, M. Zain, and H. K. Kleinman. 1992. Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo. J. Cell. Physiol. 153:614.
20. Bhartiya, D., J. W. Sklarsh, and R. K. Maheshwari. 1992. Enhanced wound healing in animal models by interferon and an interferon inducer. J. Cell. Physiol. 150:312.
21. Sidhu, G. S., D. Thaloor, A. K. Singh, P. N. Raghunath and R. K. Maheshwari. 1996. Enhanced biosynthesis of extracellular matrix proteins and TGF-beta 1 by polyinosinic-polycytidylic acid during cutaneous wound healing in vivo. J. Cell. Physiol. 169:108.
22. Kubota, Y., H. K. Kleinman, G. R. Martin, and T. J. Lawley. 1988. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J. Cell Biol. 107:1589.
23. Passaniti, A., R. M. Taylor, R. Pili, Y. Guo, P. V. Long, J. A. Haney, R. R. Pauly, D. G. Grant, and G. R. Martin. 1992. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab. Invest. 67:519.
24. Kirsner, R. S., and W. H. Eaglestein. 1993. The wound healing process. Dermatol. Clin. 11:629.
25. 1 and αβ-interferon on NK activity in tumor-bearing mice. Inter. J. Pharmacol. 11:443.
26. 4 in serum: comparision of normal, cord, homosexual and aids serum. Int. J. Immunopharm. 8:667.
27. 1 levels in human seminal plasma and follicular fluid: implication in germ cell function. Int J. Fertil. 32:375.
28. Baxevanis, C. N., E. Anasyasopoulos, G. J. Reclos, and M. Papamichail. 1990. Prothymosin-α enhances HLA-DR antigen expression on monocytes from patients with multiple sclerosis. J. Neuroimmunol 27:141.