Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumors

Radiotherapy and Oncology

Volumn 72, Issue 2, 2004, Pages 221-230

  Fenton, Bruce M ^a   Paoni, Scott F ^a   Ding, Ivan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

DC101; Hypoxia; Mammary tumors; Murine tumor models; Pericytes; VEGFR 2

Indexed keywords

UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR 2 ANTIBODY;

ANIMAL CELL; ARTICLE; BLOOD VOLUME; BREAST TUMOR; CONTROLLED STUDY; EVALUATION; HYPOXIA; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH; VASCULAR TUMOR;

ANIMALS; ANTIBODIES; BREAST NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; ENDOTHELIUM, VASCULAR; FEMALE; MAMMARY NEOPLASMS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C3H; NEOPLASM TRANSPLANTATION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 3543071067     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.05.005     Document Type: Article

References (38)

1. Benjamin L.E., Golijanin D., Itin A., Pode D., Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal [see comments]. J Clin Invest. 103:1999;159-165
2. Bergers G., Brekken R., McMahon G., et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol. 2:2000;737-744
3. Boggio K., Di Carlo E., Rovero S., et al. Ability of systemic interleukin-12 to hamper progressive stages of mammary carcinogenesis in HER2/neu transgenic mice. Cancer Res. 60:2000;359-364
4. Bruns C.J., Liu W., Davis D.W., et al. Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases. Cancer. 89:2000;488-499
5. Bruns C.J., Shrader M., Harbison M.T., et al. Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice. Int J Cancer. 102:2002;101-108
6. Fenton B.M., Lord E.M., Paoni S.F. Effects of radiation on tumor intravascular oxygenation, vascular configuration, hypoxic development, and survival. Radiat Res. 155:2001;360-368
7. Fenton B.M., Paoni S.F., Beauchamp B.K., Ding I. Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis. Br J Cancer. 86:2002;1831-1836
8. Fenton B.M., Paoni S.F., Grimwood B.G., Ding I. Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas. Int J Radiat Oncol Biol Phys. 57:2003;1038-1046
9. 2 saturation measurements. Br J Cancer. 79:1999;464-471
10. Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat Med. 9:2003;669-676
11. Folkman J., Ingber D. Inhibition of angiogenesis [Review]. Semin Cancer Biol. 3:1992;89-96
12. Gee M.S., Procopio W.N., Makonnen S., Feldman M.D., Yeilding N.M., Lee W.M. Tumor vessel development and maturation impose limits on the effectiveness of anti-vascular therapy. Am J Pathol. 162:2003;183-193
13. Gerber H.P., Dixit V., Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem. 273:1998;13313-13316
14. Gong H., Pottgen C., Stuben G., Havers W., Stuschke M., Schweigerer L. Arginine deiminase and other antiangiogenic agents inhibit unfavorable neuroblastoma growth: potentiation by irradiation. Int J Cancer. 106:2003;723-728
15. Gorski D.H., Beckett M.A., Jaskowiak N.T., et al. Blockade of vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 59:1999;3374-3378
16. Gorski D.H., Mauceri H.J., Salloum R.M., Halpern A., Seetharam S., Weichselbaum R.R. Prolonged treatment with angiostatin reduces metastatic burden during radiation therapy. Cancer Res. 63:2003;308-311
17. Griffin R.J., Williams B.W., Wild R., Cherrington J.M., Park H., Song C.W. Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response. Cancer Res. 62:2002;1702-1706
18. Gupta V.K., Jaskowiak N.T., Beckett M.A., et al. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J. 8:2002;47-54
19. Hansen-Algenstaedt N., Stoll B.R., Padera T.P., et al. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res. 60:2000;4556-4560
20. Hlatky L., Hahnfeldt P., Folkman J. Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us. J Natl Cancer Inst. 94:2002;883-893
21. Izumi Y., di Tomaso E., Hooper A., et al. Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts. Cancer Res. 63:2003;747-751
22. Jain R.K. Tumor angiogenesis and accessibility: role of vascular endothelial growth factor. Semin Oncol. 29:2002;3-9
23. Kozin S.V., Boucher Y., Hicklin D.J., Bohlen P., Jain R.K., Suit H.D. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res. 61:2001;39-44
24. Lala P.K., Al-Mutter N., Orucevic A. Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HeJ mice. Int J Cancer. 73:1997;371-380
25. Lee C.G., Heijn M., di Tomaso E., et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 60:2000;5565-5570
26. Lee J.C., Kim D.C., Gee M.S., et al. Interleukin-12 inhibits angiogenesis and growth of transplanted but not in situ mouse mammary tumor virus-induced mammary carcinomas. Cancer Res. 62:2002;747-755
27. Lord E.M., Harwell L., Koch C.J. Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res. 53:1993;5721-5726
28. Morikawa S., Baluk P., Kaidoh T., Haskell A., Jain R.K., McDonald D.M. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol. 160:2002;985-1000
29. Ning S., Laird D., Cherrington J.M., Knox S.J. The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Radiat Res. 157:2002;45-51
30. Shaheen R.M., Ahmad S.A., Liu W., et al. Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. Br J Cancer. 85:2001;584-589
31. Shaheen R.M., Tseng W.W., Vellagas R., et al. Effects of an antibody to vascular endothelial growth factor receptor-2 on survival, tumor vascularity, and apoptosis in a murine model of colon carcinomatosis. Int J Oncol. 18:2001;221-226
32. Sonveaux P., Brouet A., Havaux X., et al. Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy. Cancer Res. 63:2003;1012-1019
33. Teicher B.A., Holden S.A., Ara G., et al. Influence of an anti-angiogenic treatment on 9L gliosarcoma: oxygenation and response to cytotoxic therapy. Int J Cancer. 61:1995;732-737
34. Trotter M.J., Chaplin D.J., Olive P.L. Use of a carbocyanine dye as a marker of functional vasculature in murine tumours. Br J Cancer. 59:1989;706-709
35. Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 49:1989;6449-6465
36. Vaupel P., Kelleher D.K., Thews O. Modulation of tumor oxygenation. Int J Radiat Oncol Biol Phys. 42:1998;843-848
37. Witte L., Hicklin D.J., Zhu Z.P., et al. Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/kdr) As an anti-angiogenic therapeutic strategy [Review]. Cancer Metastasis Rev. 17:1998;155-161
38. Yokoyama Y., Green J.E., Sukhatme V.P., Ramakrishnan S. Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinomas in a transgenic mouse model. Cancer Res. 60:2000;4362-4365