Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer

Journal of Pathology

Volumn 213, Issue 2, 2007, Pages 131-139

  Taniguchi, H ^a   Yamamoto, H ^a   Akutsu, N ^a   Nosho, K ^a   Adachi, Y ^a   Imai, K ^a   Shinomura, Y ^a  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

Chromatic structure; Chromatin immunoprecipitation assay; Gastrointestinal cancer; Hedgehog signalling; Hedgehog interacting protein; Methylation specific PCR; Promoter hypermethylation; Small interfering RNA

Indexed keywords

HEDGEHOG INTERACTING PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DEMETHYLATION; EPIGENETICS; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SILENCER ELEMENT;

ADULT; AGED; CARRIER PROTEINS; CELL DIVISION; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; EPIGENESIS, GENETIC; ESOPHAGEAL NEOPLASMS; FEMALE; GASTROINTESTINAL NEOPLASMS; GENE EXPRESSION; GENE SILENCING; HEDGEHOG PROTEINS; HISTONES; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; RNA, SMALL INTERFERING; STOMACH NEOPLASMS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 35349020543     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2216     Document Type: Article

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