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Volumn 9, Issue 5, 2007, Pages 396-400

Antibodies to citrullinated proteins: Pathogenic and diagnostic significance

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTICITRULLINATED PROTEIN; FILAGGRIN; UNCLASSIFIED DRUG;

EID: 35349005331     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-007-0063-5     Document Type: Review
Times cited : (7)

References (33)
  • 1
    • 0034767917 scopus 로고    scopus 로고
    • The innate immune system in rheumatoid arthritis
    • Arend WP: The innate immune system in rheumatoid arthritis. Arth Rheum 2001, 44:2224-2234.
    • (2001) Arth Rheum , vol.44 , pp. 2224-2234
    • Arend, W.P.1
  • 2
    • 34247101156 scopus 로고    scopus 로고
    • The role of T cells in rheumatoid arthritis: New subsets and new targets
    • Toh ML, Miossec P: The role of T cells in rheumatoid arthritis: new subsets and new targets. Cur Opin Rheum 2007, 19:284-288.
    • (2007) Cur Opin Rheum , vol.19 , pp. 284-288
    • Toh, M.L.1    Miossec, P.2
  • 3
    • 0034044349 scopus 로고    scopus 로고
    • New insights into the pathogenesis of rheumatoid arthritis
    • Weyand CM: New insights into the pathogenesis of rheumatoid arthritis. Rheumatology 2000, 39(Suppl 1):3-8.
    • (2000) Rheumatology , vol.39 , Issue.SUPPL. 1 , pp. 3-8
    • Weyand, C.M.1
  • 4
    • 0035001641 scopus 로고    scopus 로고
    • Pathogenesis of rheumatoid arthritis. Role of B lymphocytes
    • Zhang Z, Bridges SL: Pathogenesis of rheumatoid arthritis. Role of B lymphocytes. Rheum Dis Clin North Am 2001, 27:335-353.
    • (2001) Rheum Dis Clin North Am , vol.27 , pp. 335-353
    • Zhang, Z.1    Bridges, S.L.2
  • 5
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • Edwards JC, Szczepanski L, Szechinski J, et al.: Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Eng J Med 2004, 350:2572-2581.
    • (2004) N Eng J Med , vol.350 , pp. 2572-2581
    • Edwards, J.C.1    Szczepanski, L.2    Szechinski, J.3
  • 7
    • 1142274317 scopus 로고    scopus 로고
    • The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease
    • Comprehensive review of RA models from a leading expert
    • Monach PA, Benoist C, Mathis D: The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease. Adv Immunol 2004, 82:217-248. Comprehensive review of RA models from a leading expert.
    • (2004) Adv Immunol , vol.82 , pp. 217-248
    • Monach, P.A.1    Benoist, C.2    Mathis, D.3
  • 9
    • 0031974911 scopus 로고    scopus 로고
    • Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies
    • Schellekens GA, de Jong BA, van den Hoogen FH, et al.: Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998, 101:273-281.
    • (1998) J Clin Invest , vol.101 , pp. 273-281
    • Schellekens, G.A.1    de Jong, B.A.2    van den Hoogen, F.H.3
  • 10
    • 0035869593 scopus 로고    scopus 로고
    • The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the a- and b-chains of fibrin
    • Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E, et al.: The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the a- and b-chains of fibrin. J Immunol 2001, 166:4177-4184.
    • (2001) J Immunol , vol.166 , pp. 4177-4184
    • Masson-Bessiere, C.1    Sebbag, M.2    Girbal-Neuhauser, E.3
  • 11
    • 0034467062 scopus 로고    scopus 로고
    • Citrullination: A small change for a protein with great consequences for rheumatoid arthritis
    • van Venrooij WJ, Pruijn GJ: Citrullination: a small change for a protein with great consequences for rheumatoid arthritis. Arthritis Res 2000, 2:249-251.
    • (2000) Arthritis Res , vol.2 , pp. 249-251
    • van Venrooij, W.J.1    Pruijn, G.J.2
  • 12
    • 0032960781 scopus 로고    scopus 로고
    • The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues
    • Girbal-Neuhauser E, Durieux JJ, Arnaud M, et al.: The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol 1999, 162:585-594.
    • (1999) J Immunol , vol.162 , pp. 585-594
    • Girbal-Neuhauser, E.1    Durieux, J.J.2    Arnaud, M.3
  • 13
    • 17744377384 scopus 로고    scopus 로고
    • Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset
    • Goldbach-Mansky R, Lee J, McCoy A, et al.: Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arth Res Ther 2000, 2:236-243.
    • (2000) Arth Res Ther , vol.2 , pp. 236-243
    • Goldbach-Mansky, R.1    Lee, J.2    McCoy, A.3
  • 14
    • 0042386360 scopus 로고    scopus 로고
    • Clinical utility of the anti-CCP assay in patients with rheumatic diseases
    • Lee DM, Schur PH: Clinical utility of the anti-CCP assay in patients with rheumatic diseases. Ann Rheum Dis 2003, 62:870-874.
    • (2003) Ann Rheum Dis , vol.62 , pp. 870-874
    • Lee, D.M.1    Schur, P.H.2
  • 15
    • 0034091322 scopus 로고    scopus 로고
    • The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide
    • Schellekens GA, Visser H, de Jong BA, et al.: The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000, 43:155-163.
    • (2000) Arthritis Rheum , vol.43 , pp. 155-163
    • Schellekens, G.A.1    Visser, H.2    de Jong, B.A.3
  • 16
    • 23744476831 scopus 로고    scopus 로고
    • Clinical utility of the anti-CCP assay: Experiences with 700 patients
    • Sauerland U, Becker H, Seidel M, et al.: Clinical utility of the anti-CCP assay: experiences with 700 patients. Ann N Y Acad Sci 2005, 1050:314-318.
    • (2005) Ann N Y Acad Sci , vol.1050 , pp. 314-318
    • Sauerland, U.1    Becker, H.2    Seidel, M.3
  • 17
    • 33947371653 scopus 로고    scopus 로고
    • Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis
    • Coenen D, Verschueren P, Westhovens R, Bossuyt X: Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis. Clin Chem 2007, 53:498-504.
    • (2007) Clin Chem , vol.53 , pp. 498-504
    • Coenen, D.1    Verschueren, P.2    Westhovens, R.3    Bossuyt, X.4
  • 18
    • 33846691023 scopus 로고    scopus 로고
    • Very recent onset rheumatoid arthritis: Clinical and serological patient characteristics associated with radiographic progression over the first years of disease
    • Machold KP, Stamm TA, Nell VP, et al.: Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease. Rheumatology (Oxford) 2007, 46:342-349.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 342-349
    • Machold, K.P.1    Stamm, T.A.2    Nell, V.P.3
  • 19
    • 29144460980 scopus 로고    scopus 로고
    • Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: Contrasting effects of HLA-DR3 and the shared epitope alleles
    • Excellent genetic study of relationships between ACPA, RF, and HLA genes
    • Irigoyen P, Lee AT, Wener MH, et al.: Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. Arthritis Rheum 2005, 52:3813-3818. Excellent genetic study of relationships between ACPA, RF, and HLA genes.
    • (2005) Arthritis Rheum , vol.52 , pp. 3813-3818
    • Irigoyen, P.1    Lee, A.T.2    Wener, M.H.3
  • 20
    • 33745779659 scopus 로고    scopus 로고
    • The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis
    • Russell AS, Devani A, Maksymowych WP: The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. J Rheum 2006, 33:1240-1242.
    • (2006) J Rheum , vol.33 , pp. 1240-1242
    • Russell, A.S.1    Devani, A.2    Maksymowych, W.P.3
  • 21
    • 13444265935 scopus 로고    scopus 로고
    • Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis
    • Raza K, Breese M, Nightingale P, et al.: Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis. J Rheum 2005, 32:203-207.
    • (2005) J Rheum , vol.32 , pp. 203-207
    • Raza, K.1    Breese, M.2    Nightingale, P.3
  • 22
    • 31044445025 scopus 로고    scopus 로고
    • Klareskog L, Stolt P, Lundberg K, et al.: A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006, 54:38-46. Provides a compelling mechanism whereby smoking leads to increased citrullination in the lung, which triggers an immune response primarily in individuals who express the HLA shared epitope. This is an intriguing model that should be explored further.
    • Klareskog L, Stolt P, Lundberg K, et al.: A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006, 54:38-46. Provides a compelling mechanism whereby smoking leads to increased citrullination in the lung, which triggers an immune response primarily in individuals who express the HLA shared epitope. This is an intriguing model that should be explored further.
  • 23
    • 18744430797 scopus 로고    scopus 로고
    • Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    • Rantapaa Dahlqvist S, de Jong BA, Hallmans G, et al.: Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003, 48:2741-2749.
    • (2003) Arthritis Rheum , vol.48 , pp. 2741-2749
    • Rantapaa Dahlqvist, S.1    de Jong, B.A.2    Hallmans, G.3
  • 24
    • 7044269900 scopus 로고    scopus 로고
    • A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with the future onset of rheumatoid arthritis
    • Berglin E, Padyukov L, Sundin U, et al.: A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with the future onset of rheumatoid arthritis. Arth Res Ther 2004, 6:R303-R308.
    • (2004) Arth Res Ther , vol.6
    • Berglin, E.1    Padyukov, L.2    Sundin, U.3
  • 25
    • 1042290337 scopus 로고    scopus 로고
    • Specific autoantibodies precede the symptoms of rheumatoid arthritis: Study of serial measurements in blood donors
    • Nielen MM, van Schaardenburg D, Reesink HW, et al.: Specific autoantibodies precede the symptoms of rheumatoid arthritis: study of serial measurements in blood donors. Arthritis Rheum 2004, 50:380-386.
    • (2004) Arthritis Rheum , vol.50 , pp. 380-386
    • Nielen, M.M.1    van Schaardenburg, D.2    Reesink, H.W.3
  • 26
    • 5644239636 scopus 로고    scopus 로고
    • A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
    • Padyukov L, Silva C, Stolt P, et al.: A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 2004, 50:3085-3092.
    • (2004) Arthritis Rheum , vol.50 , pp. 3085-3092
    • Padyukov, L.1    Silva, C.2    Stolt, P.3
  • 28
    • 33746888249 scopus 로고    scopus 로고
    • Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
    • Kaneko Y, Nimmerjahn F, Ravetch JV: Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science 2006, 313:670-673.
    • (2006) Science , vol.313 , pp. 670-673
    • Kaneko, Y.1    Nimmerjahn, F.2    Ravetch, J.V.3
  • 29
    • 2942625705 scopus 로고    scopus 로고
    • Staging the initiation of autoantibody-induced arthritis: A critical role for immune complexes
    • Wipke BT, Wang Z, Nagengast W, et al.: Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes. J Immunol 2004, 172:7694-7702.
    • (2004) J Immunol , vol.172 , pp. 7694-7702
    • Wipke, B.T.1    Wang, Z.2    Nagengast, W.3
  • 30
    • 33645511657 scopus 로고    scopus 로고
    • Antibodies to citrullinated proteins enhance tissue injury in experimental arthritis
    • Kuhn KA, Kulik L, Tomooka B, et al.: Antibodies to citrullinated proteins enhance tissue injury in experimental arthritis. J Clin Invest 2006, 116:961-973.
    • (2006) J Clin Invest , vol.116 , pp. 961-973
    • Kuhn, K.A.1    Kulik, L.2    Tomooka, B.3
  • 31
    • 0038107566 scopus 로고    scopus 로고
    • The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-BRB1*0401 MHC Class II molecule
    • Hill JA, Southwood S, Sette A, et al.: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-BRB1*0401 MHC Class II molecule. J Immunol 2003, 171:538-541.
    • (2003) J Immunol , vol.171 , pp. 538-541
    • Hill, J.A.1    Southwood, S.2    Sette, A.3
  • 32
    • 33746214870 scopus 로고    scopus 로고
    • Cutting edge: Unique T cells that recognize citrullinated peptides are a feature of protein immunization
    • Ireland J, Herzog J, Unanue ER: Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization. J Immunol 2006, 177:1421-1425.
    • (2006) J Immunol , vol.177 , pp. 1421-1425
    • Ireland, J.1    Herzog, J.2    Unanue, E.R.3
  • 33
    • 43949162155 scopus 로고
    • Defining criteria for autoimmune diseases (Witebsky's postulates revisited)
    • Rose NR, Bona C: Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 1993, 14:426-430.
    • (1993) Immunol Today , vol.14 , pp. 426-430
    • Rose, N.R.1    Bona, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.