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Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: Contrasting effects of HLA-DR3 and the shared epitope alleles
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Excellent genetic study of relationships between ACPA, RF, and HLA genes
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Irigoyen P, Lee AT, Wener MH, et al.: Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. Arthritis Rheum 2005, 52:3813-3818. Excellent genetic study of relationships between ACPA, RF, and HLA genes.
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Klareskog L, Stolt P, Lundberg K, et al.: A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006, 54:38-46. Provides a compelling mechanism whereby smoking leads to increased citrullination in the lung, which triggers an immune response primarily in individuals who express the HLA shared epitope. This is an intriguing model that should be explored further.
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