A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis

Arthritis Research and Therapy

Volumn 6, Issue 4, 2004, Pages

  Berglin, Ewa ^a   Padyukov, Leonid ^b   Sundin, Ulf ^b   Hallmans, Göran ^a   Stenlund, Hans ^a   van Venrooij, Walther J ^c   Klareskog, Lars ^b   Dahlqvist, Solbritt Rantapää ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

anti CCP antibodies; rheumatoid arthritis; rheumatoid factor; shared epitope

Indexed keywords

AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE; HLA DR ANTIGEN; HLA-DRB1 ANTIGEN; RHEUMATOID FACTOR;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; BLOOD; CASE CONTROL STUDY; COHORT ANALYSIS; FEMALE; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; RHEUMATOID ARTHRITIS;

ADULT; AGED; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; PEPTIDES, CYCLIC; RHEUMATOID FACTOR;

EID: 7044269900     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar1187     Document Type: Article

References (16)

1. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324. DOI: 10.1002/art.1780310302
2. Aho K, Palosuo T, Raunio V, Puska P, Aromaa A, Salonen JT: When does rheumatoid disease start?. Arthritis Rheum. 1985, 28: 485-489. DOI: 10.1002/art.1780280503
3. Rantapää-Dahlqvist S, de Jong BAW, Berglin E, Hallmans G, Wadell G, Stenlund H, Sundin U, van Venrooij WJ: Antibodies against cyclic citrullinated peptide (CCP) and immunoglobulin-A rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003, 10: 2741-2749. 10.1002/art.11223. DOI: 10.1002/art.11223
4. Jawaheer D, Gregersen PK: Rheumatoid arthritis. The genetic components. Rheum Dis Clin North Am. 2002, 28: 1-15. 10.1016/S0889-857X(03)00066-8. DOI: 10.1016/S0889-857X(03)00066-8
5. Rantapää Dahlqvist S: Genetic markers in rheumatoid arthritis. Scand J Rheumatol. 1986, Suppl 58: 1-29.
6. Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E: Cutting edge: The conversion of ariginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC classII molecule. J Immunol. 2003, 171: 538-541. DOI: 10.4049/jimmunol.171.2.538
7. Goldbach-Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen JS, Steiner G, Rosen A, Zhang C, Menard HA, Zhou ZJ, Palosuo T, Van Venrooij WJ, Wilder RL, Klippel JH, Schumacher HR, El-Gabalawy HS: Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res. 2000, 2: 236-243. 10.1186/ar93. DOI: 10.1186/ar93
8. Bas S, Genevay S, Meyer O, Gabay C: Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis. Rheumatology. 2003, 42: 677-680. 10.1093/rheumatology/keg184. DOI: 10.1093/rheumatology/keg184
9. Zanelli E, Breedveld FC, Vries de RRP: HLA association with autoimmune disease: a failure to protect?. Rheumatology. 2000, 39: 1060-1066. 10.1093/rheumatology/39.10.1060. DOI: 10.1093/rheumatology/39.10.1060
10. Wernhoff P, Olofsson P, Holmdahl R: The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis. Arthritis Rheum. 2003, 48: 3584-3596. 10.1002/art.11342. DOI: 10.1002/art.11342
11. Gorman JD, Criswell LA: The shared epitope and severity of rheumatoid arthritis. Rheum Dis Clin North Am. 2002, 28: 59-78. 10.1016/S0889-857X(03)00069-3. DOI: 10.1016/S0889-857X(03)00069-3
12. Deighton CM, Walker DJ, Griffiths ID, Roberts DF: The contribution of HLA to rheumatoid arthritis. Clin Genet. 1989, 36: 178-182. DOI: 10.1111/j.1399-0004.1989.tb03185.x
13. Rigby AS, Silman AJ, Voelm L, Gregory JC, Ollier WE, Khan MA, Nepom GT, Thomson G: Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred. Genet Epidemiol. 1991, 8: 153-175. DOI: 10.1002/gepi.1370080303
14. Rigby AS, Voelm L, Silman AJ: Epistatic modeling in rheumatoid arthritis: an application of the Risch theory. Genet Epidemiol. 1993, 10: 311-320. DOI: 10.1002/gepi.1370100504
15. Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M, Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, Ohtsuki M, Furukawa H, Yoshino S, Yukioka M, Tohma S, Matsubara T, Wakitani S, Teshima R, Nishioka Y, Sekine A, Iida A, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet. 2003, 34: 395-402. 10.1038/ng1206. DOI: 10.1038/ng1206
16. Caponi L, Petit-Teixeira E, Sebbag M, Bongiorni F, Moscato S, Pratesi F, Osorio J, Guerrin-Weber M, Cornelis F, Serre G, Migliorini P: Analysis of the peptidylarginine deiminase V gene in rheumatoid arthritis [abstract]. Arthritis Res. 2003, Suppl 5: 1-