Citrullination: A small change for a protein with great consequences for rheumatoid arthritis

Arthritis Research

Volumn 2, Issue 4, 2000, Pages 249-251

  van Venrooij, W J ^a   Pruijn, G J M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Autoantibody; Autoantigen; Citrullination; Deimination; Rheumatoid arthritis

Indexed keywords

ANTICITRULLINATED PROTEIN ANTIBODY; ARGININE; AUTOANTIBODY; AUTOANTIGEN; CITRULLINE; EPITOPE; FILAGGRIN; MYELIN BASIC PROTEIN; PROTEIN ANTIBODY; PROTEIN ARGININE DEIMINASE; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL CELL; APOPTOSIS; B LYMPHOCYTE; ENZYME ACTIVITY; HORMONAL REGULATION; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; NOTE; PROTEIN PROCESSING; RHEUMATOID ARTHRITIS;

ANIMALS; APOPTOSIS; ARGININE; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; CITRULLINE; HUMANS;

EID: 0034467062     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar95     Document Type: Note

References (20)

1. Antinuclear antibodies: Diagnostic markers for autoimmune disease and probes for cell biology
2. Death, autoantigen modifications, and tolerance
3. A new serum factor in patients with rheumatoid arthritis. The antiperinuclear factor
4. The cytokeratin filament-aggregating protein filaggrin is the target of the so-called 'antikeratin antibodies', autoantibodies specific for rheumatoid arthritis
5. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies
6. The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies
7. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are post-translationally generated on various sites of (pro)filaggrin by deimination of arginine residues
8. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide
9. In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum
10. Synovial target antigens of antifilaggrin autoantibodies are deiminated forms of fibrin alpha and beta chains
11. Protein unfolding by peptidy-larginine deiminase
12. Expression of peptidy-larginine deiminase in the epithelial cells of mouse uterine is dependent on estrogen
13. Peptidylarginine deiminase in rat pituitary: Sex difference, estrous cycle-related changes and estrogen dependence
14. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
15. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages
16. Deimination of 70-kD nuclear protein during epidermal apoptotic events in vitro
17. 2+-dependent deimination-induced disassembly of intermediate filaments involves specific modifications of the amino-terminal head domain
18. Apoptosis in rheumatoid arthritis