Pyruvate protects against kainate-induced epileptic brain damage in rats

Experimental Neurology

Volumn 208, Issue 1, 2007, Pages 159-167

  Kim, Tae Youn ^a   Yi, Jung Sun ^a   Chung, Sun Ju ^a   Kim, Dong Kyu ^a   Byun, Hyae Ran ^a   Lee, Joo Yong ^a   Koh, Jae Young ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Antiepileptic drug; Epilepsy; Glycolysis; Heat shock protein; Kainate induced seizure; Neuroprotection; Pyruvate; TFL Zn; TUNEL; Zinc

Indexed keywords

HEAT SHOCK PROTEIN 70; KAINIC ACID; PYRUVATE SODIUM; SODIUM CHLORIDE; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; EPILEPTIC STATE; GLUCOSE METABOLISM; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; NEOCORTEX; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OSMOLARITY; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEIZURE; SPRAGUE DAWLEY RAT; THALAMUS;

ANIMALS; BRAIN DAMAGE, CHRONIC; CELL DEATH; EPILEPSY; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; HSP70 HEAT-SHOCK PROTEINS; KAINIC ACID; MALE; NEOCORTEX; NEURONS; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; THALAMUS; ZINC;

EID: 35348985927     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2007.08.013     Document Type: Article

References (55)

1. 2+ from brain tissue during activity. Nature 308 (1984) 734-736
2. Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14 (1985) 375-403
3. Chapman A.G., Westerberg E., Premachandra M., and Meldrum B.S. Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by l-allyl-glycine, bicuculline, and kainic acid. J. Neurochem. 43 (1984) 62-70
4. Choi D.W., and Koh J.Y. Zinc and brain injury. Annu. Rev. Neurosci. 21 (1998) 347-375
5. Courtney M.J., Enkvist M.O., and Akerman K.E. The calcium response to the excitotoxin kainate is amplified by subsequent reduction of extracellular sodium. Neuroscience 68 (1995) 1051-1057
6. Desagher S., Glowinski J., and Premont J. Pyruvate protects neurons against hydrogen-induced toxicity. J. Neurosci. 17 (1997) 9060-9067
7. Du F., Eid T., Lothman E.W., Kohler C., and Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. J. Neurosci. 15 (1995) 6301-6313
8. Dutcher S.A., Underwood B.D., Walker P.D., Diaz F.G., and Michael D.B. Patterns of heat-shock protein 70 biosynthesis following human traumatic brain injury. J. Neurotrauma 15 (1998) 411-420
9. Fisher R.S. Animal models of the epilepsies. Brain Res. Brain Res. Rev. 14 (1989) 245-278
10. Frederickson C.J., Hernandez M.D., and McGinty J.F. Translocation of zinc may contribute to seizure-induced death of neurons. Brain Res. 480 (1989) 317-321
11. Frederickson C.J., Suh S.W., Silva D., Frederickson C.J., and Thompson R.B. Importance of zinc in the central nervous system: the zinc-containing neuron. J. Nutr. 130 (2000) 1471S-1483S
12. Gaspary H., Graham S.H., Sagar S.M., and Sharp F.R. HSP70 heat shock protein induction following global ischemia in the rat. Brain Res. Mol. Brain Res. 34 (1995) 327-332
13. Gruenthal M., Armstrong D.R., Ault B., and Nadler J.V. Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide. Exp. Neurol. 93 (1986) 621-630
14. Hidalgo J., Aschner M., Zatta P., and Vasak M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res. Bull. 55 (2001) 133-145
15. Howell G.A., Welch M.G., and Frederickson C.J. Stimulation-induced uptake and release of zinc in hippocampal slices. Nature 308 (1984) 736-738
16. Jiang D., Sullivan P.G., Sensi S.L., Steward O., and Weiss J.H. Zn (2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. J. Biol. Chem. 276 (2001) 47524-47529
17. Kato K., Puttfarcken P.S., Lyons W.E., and Coyle J.T. Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures. J. Pharmacol. Exp. Ther. 256 (1991) 402-411
18. Kim Y.H., and Koh J.Y. The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture. Exp. Neurol. 177 (2002) 407-418
19. 2+ entry produces oxidative neuronal necrosis in cortical cell cultures. Eur. J. Neurosci. 11 (1999) 327-334
20. Kim Y.H., Kim E.Y., Gwag B.J., Sohn S., and Koh J.Y. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience 89 (1999) 175-182
21. Koh J.Y., Suh S.W., Gwag B.J., He Y.Y., Hsu C.Y., and Choi D.W. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272 (1996) 1013-1016
22. Lee J.Y., Cole T.B., Palmiter R.D., and Koh J.Y. Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin. J. Neurosci. 20 (2000) RC79
23. Lee J.Y., Park J.H., Kim Y.H., Kim D.H., Kim C.G., and Koh J.Y. Induction by synaptic zinc of heat shock protein-70 in hippocampus after kainate seizures. Exp. Neurol. 161 (2000) 433-441
24. Lee J.Y., Kim Y.H., and Koh J.Y. Protection by pyruvate against transient forebrain ischemia in rats. J. Neurosci. 21 (2001) RC171
25. Lee J.Y., Kim J.H., Palmiter R.D., and Koh J.Y. Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury. Exp. Neurol. 184 (2003) 337-347
26. Lothman E.W., and Collins R.C. Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates. Brain Res. 218 (1981) 299-318
27. Lowenstein D.H., Bleck T., and Macdonald R.L. It's time to reverse the definition of status epilepticus. Epilepsia 40 (1999) 120-122
28. Nadler J.V. Minireview; Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci. 29 (1981) 2031-2042
29. Nadler J.V., Perry B.W., and Cotman C.W. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature 271 (1978) 676-677
30. Nadler J.V., Perry B.W., Gentry C., and Cotman C.W. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J. Comp. Neurol. 192 (1980) 333-359
31. Noh K.M., and Koh J.Y. Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J. Neurosci. 20 (2000) RC111
32. O'Donnell-Tormey J., Nathan C.F., Lanks K., DeBoer C.J., and de la Harpe J. Secretion of pyruvate. An antioxidant of mammalian cell. J. Exp. Med. 165 (1987) 500-514
33. Olney J.W., Rhee V., and Ho O.L. Kainic acid: a powerful neurotoxic analogue of glutamate. Brain Res. 77 (1974) 507-512
34. Palumaa P., Eriste E., Njunkova O., Pokras L., Jornvall H., and Sillard R. Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively. Biochemistry 41 (2002) 6158-6163
35. Pearce L.L., Gandley R.E., Han W., Wasserloos K., Stitt M., Kanai A.J., McLaughlin M.K., Pitt B.R., and Levitan E.S. Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 477-482
36. Phelps S., Mitchell J., and Wheal H.V. Changes to synaptic ultrastructure in field CA1 of the rat hippocampus following intracerebroventricular injection of kainic acid. Neuroscience 40 (1991) 687-699
37. Pitkanen A., and Sutula T.P. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol. 1 (2002) 173-181
38. Planas A.M., Soriano M.A., Estrada A., Sanz O., Marin F., and Ferrer I. The heat shock stress response after brain lesions: induction of 72 kDa heat shock protein (cell types involved, axonal transport, transcriptional regulation) and protein synthesis inhibition. Prog. Neurobiol. 51 (1997) 607-636
39. Schwob J.E., Fuller T., Price J.L., and Olney J.W. Widespread patterns of neuronal damage following systemic or intracerebral injection of kainic acid: a histological study. Neuroscience 5 (1980) 991-1014
40. 2+ permeable AMPA channels and consequent ROS production. Neuroreport 10 (1999) 1723-1727
41. 2+ uptake and persistent mitochondrial dysfunction. Eur. J. Neurosci. 12 (2000) 3813-3818
42. Sheline C.T., Behrens M.M., and Choi D.W. Zinc-induced cortical neuronal death: Contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis. J. Neurosci. 20 (2000) 3139-3146
43. Sperk G. Kainic acid seizures in the rat. Prog. Neurobiol. 42 (1994) 1-32
44. Sperk G., Lassmann H., Baran H., Kish S.H., Seitelberger F., and Hornykiewicz O. Kainic acid induced seizures: neurochemical and histopathological changes. Neuroscience 10 (1983) 1301-1315
45. Suh S.W., Chen J.W., Motamedi M., Bell B., Listiak K., Pons N.F., Danscher G., and Frederickson C.J. Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury. Brain Res. 852 (2000) 268-273
46. Suh S.W., Aoyama K., Matsumori Y., Liu J., and Swanson R.A. Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment. Diabetes 54 (2005) 1452-1458
47. Sutula T.P., and Pitkanen A. More evidence for seizure-induced neuron loss: is hippocampal sclerosis both cause and effect of epilepsy?. Neurology 57 (2001) 169-170
48. Sutula, T.P., Hagen, J., Pitkanen, A., 2003. Do epileptic seizures damage the brain? Curr. Opin. Neurol. 16, 189-195.
49. Tauck D.L., and Nadler J.V. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 5 (1985) 1016-1022
50. Truong-Tran A.Q., Ruffin R.E., and Zalewski P.D. Visualization of labile zinc and its role in apoptosis of primary airway epithelial cells and cell lines. Am. J. Physiol., Lung Cell. Mol. Physiol. 279 (2000) L1172-L1183
51. 2+: a novel ionic mediator of neural injury in brain disease. Trends Pharmacol. Sci. 21 (2000) 395-401
52. Yi J.S., Lee S.K., Sato T.A., and Koh J.Y. Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat. Neurosci. Lett. 347 (2003) 126-130
53. Yi J.S., Kim T.Y., Kim D.K., and Koh J.Y. Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia. Neurobiol. Dis. 26 (2007) 94-104
54. Zalewski P.D., Forbes I.J., Seamark R.F., Borlinghaus R., Betts W.H., Lincoln S.F., and Ward A.D. Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin. Chem. Biol. 1 (1994) 153-161
55. Zhang X., Gelowitz D.L., Lai C.T., Boulton A.A., and Yu P.H. Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70. Eur. J. Neurosci. 9 (1997) 760-769