Expression of Candida albicans Sfu I in fission yeast complements the loss of the iron-regulatory transcription factor Fep I and requires Tup co-repressors

Yeast

Volumn 24, Issue 10, 2007, Pages 883-900

  Pelletier, Benoit ^a   Mercier, Alexandre ^a   Durand, Mathieu ^a   Peter, Chardeen ^a   Jbel, Mehdi ^a   Beaudoin, Jude ^a   Labbé, Simon ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Candida albicans; Fission yeast; GATA type transcription factor; Iron homeostasis; Tup co repressor

Indexed keywords

CYSTEINE; GREEN FLUORESCENT PROTEIN; IRON; IRON REGULATORY FACTOR; REPRESSOR PROTEIN; SUPPRESSOR OF FERRIC UPTAKE 1 PROTEIN; TRANSCRIPTION FACTOR FE PROTEIN 1; TRANSCRIPTION FACTOR GATA; TUP11 PROTEIN; TUP12 PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ALLELE; AMINO TERMINAL SEQUENCE; ARTICLE; CANDIDA ALBICANS; CELL MUTANT; CELL NUCLEUS; CONTROLLED STUDY; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENE FUSION; IRON TRANSPORT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; REGULATORY MECHANISM; SCHIZOSACCHAROMYCES POMBE; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM;

AMINO ACID SEQUENCE; CANDIDA ALBICANS; FUNGAL PROTEINS; GATA TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, FUNGAL; IRON; MOLECULAR SEQUENCE DATA; REPRESSOR PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

CANDIDA ALBICANS; ESCHERICHIA COLI; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 35348969764     PISSN: 0749503X     EISSN: 10970061     Source Type: Journal    
DOI: 10.1002/yea.1539     Document Type: Article

References (65)

1. Alfa C, Fantes P, Hyams J, McLeod M, Warbrick E. 1993. In Experiments with Fission Yeast: A Laboratory Course Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
2. An Z, Mei B, Yuan WM, Leong SA. 1997a. The distal GATA sequences of the sid1 promoter of Ustilago maydis mediate iron repression of siderophore production and interact directly with Urbs1, a GATA family transcription factor. EMBO J 16: 1742-1750.
3. An Z, Zhao Q, McEvoy J, et al. 1997b. The second finger of Urbs1 is required for iron-mediated repression of sid1 in Ustilago maydis. Proc Natl Acad Sci USA 94: 5882-5887.
4. Ardon O, Bussey H, Philpott C, et al. 2001. Identification of a Candida albicans ferrichrome transporter and its characterization by expression in Saccharomyces cerevisiae. J Biol Chem 276: 43049-43055.
5. Bezanilla M, Forsburg SL, Pollard TD. 1997. Identification of a second myosin-II in Schizosaccharomyces pombe: Myp2p is conditionally required for cytokinesis. Mol Biol Cell 8: 2693-2705.
6. Blaiseau PL, Lesuisse E, Camadro JM. 2001. Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276: 34221-34226.
7. Braun BR, Head WS, Wang MX, Johnson AD. 2000. Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics 156: 31-44.
8. Doring G, Pfestorf M, Botzenhart K, Abdallah MA. 1988. Impact of proteases on iron uptake of Pseudomonas aeruginosa pyoverdin from transferrin and lactoferrin. Infect Immun 56: 291-293.
9. Eck R, Hundt S, Hartl A, Roemer E, Kunkel W. 1999. A multicopper oxidase gene from Candida albicans: cloning, characterization and disruption. Microbiology 145: 2415-2422.
10. Fox KR, Grigg GW, Waring MJ. 1987. Sequence-selective binding of phleomycin to DNA. Biochem J 243: 847-851.
11. Garcia MG, O'Connor JE, Garcia LL, et al. 2001. Isolation of a Candida albicans gene, tightly linked to URA3, coding for a putative transcription factor that suppresses a Saccharomyces cerevisiae aft1 mutation. Yeast 18: 301-311.
12. Gavin IM, Kladde MP, Simpson RT. 2000. Tup1p represses Mcm1p transcriptional activation and chromatin remodeling of an a-cell-specific gene. EMBO J 19: 5875-5883.
13. Haas H. 2003. Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage. Appl Microbiol Biotechnol 62: 316-330.
14. Haas H, Zadra I, Stoffler G, Angermayr K. 1999. The Aspergillus nidulans GATA factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake. J Biol Chem 274: 4613-4619.
15. Halliwell B, Gutteridge JM. 1992. Biologically relevant metal ion-dependent hydroxyl radical generation: an update. FEBS Lett 307: 108-112.
16. Hammacott JE, Williams PH, Cashmore AM. 2000. Candida albicans CFL1 encodes a functional ferric reductase activity that can rescue a Saccharomyces cerevisiae fre1 mutant. Microbiology 146: 869-876.
17. Harrison KA, Marzluf GA. 2002. Characterization of DNA binding and the cysteine rich region of SRE, a GATA factor in Neurospora crassa involved in siderophore synthesis. Biochemistry 41: 15288-15295.
18. Hentze MW, Muckenthaler MU, Andrews NC. 2004. Balancing acts: molecular control of mammalian iron metabolism. Cell 117: 285-297.
19. Heymann P, Gerads M, Schaller M, et al. 2002. The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion. Infect Immun 70: 5246-5255.
20. Hu CJ, Bai C, Zheng XD, Wang YM, Wang Y. 2002. Characterization and functional analysis of the siderophore-iron transporter CaArn1p in Candida albicans. J Biol Chem 277: 30598-30605.
21. Iwaki T, Takegawa K. 2004. A set of loxP marker cassettes for cre-mediated multiple gene disruption in Schizosaccharomyces pombe. Biosci Biotechnol Biochem 68: 545-550.
22. Jung WH, Sham A, White R, Kronstad JW. 2006. Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans. PLoS Biol 4: 2282-2295.
23. Kaplan J, McVey Ward D, Crisp RJ, Philpott CC. 2006. Iron-dependent metabolic remodeling in Saccharomyces cerevisiae. Biochim Biophys Acta 1763: 646-651.
24. Keeney JB, Boeke JD. 1994. Efficient targeted integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe. Genetics 136: 849-856.
25. Kelly KA, Havrilla CM, Brady TC, Abramo KH, Levin ED. 1998. Oxidative stress in toxicology: established mammalian and emerging piscine model systems. Environ Health Perspect 106: 375-384.
26. Kim J, Hirsch JP. 1998. A nucleolar protein that affects mating efficiency in Saccharomyces cerevisiae by altering the morphological response to pheromone. Genetics 149: 795-805.
27. Knight SA, Lesuisse E, Stearman R, Klausner RD, Dancis A. 2002. Reductive iron uptake by Candida albicans: role of copper, iron and the TUP1 regulator. Microbiology 148: 29-40.
28. Knight SA, Vilaire G, Lesuisse E, Dancis A. 2005. Iron acquisition from transferrin by Candida albicans depends on the reductive pathway. Infect Immun 73: 5482-5492.
29. Kohrer K, Domdey H. 1991. Preparation of high molecular weight RNA. Methods Enzymol 194: 398-405.
30. Kosman DJ. 2003. Molecular mechanisms of iron uptake in fungi. Mol Microbiol 47: 1185-1197.
31. Kross J, Henner WD, Hecht SM, Haseltine WA. 1982. Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin. Biochemistry 21: 4310-4318.
32. Labbé S, Pelletier B, Mercier A. 2007. Iron homeostasis in the fission yeast Schizosaccharomyces pombe. Biometals 20: 523-537.
33. Labbé S, Peña MMO, Fernandes AR, Thiele DJ. 1999. A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe. J Biol Chem 274: 36252-36260.
34. Labbé S, Zhu Z, Thiele DJ. 1997. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway. J Biol Chem 272: 15951-15958.
35. Lan CY, Rodarte G, Murillo LA, et al. 2004. Regulatory networks affected by iron availability in Candida albicans. Mol Microbiol 53: 1451-1469.
36. Lesuisse E, Knight SA, Camadro JM, Dancis A. 2002. Siderophore uptake by Candida albicans: effect of serum treatment and comparison with Saccharomyces cerevisiae. Yeast 19: 329-340.
37. Massé E, Arguin M. 2005. Ironing out the problem: new mechanisms of iron homeostasis. Trends Biochem Sci 30: 462-468.
38. Miller JH. 1972. Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY; 352-355.
39. Miranda I, Silva R, Santos MA. 2006. Evolution of the genetic code in yeasts. Yeast 23: 203-213.
40. Murad AM, d'Enfert C, Gaillardin C, et al. 2001. Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1. Mol Microbiol 42: 981-993.
41. Nobile CJ, Mitchell AP. 2006. Genetics and genomics of Candida albicans biofilm formation. Cell Microbiol 8: 1382-1391.
42. Pelletier B, Beaudoin J, Mukai Y, Labbé S. 2002. Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe. J Biol Chem 277: 22950-22958.
43. Pelletier B, Beaudoin J, Philpott CC, Labbé S. 2003. Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Res 31: 4332-4344.
44. Pelletier B, Trott A, Morano KA, Labbé S. 2005. Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. J Biol Chem 280: 25146-25161.
45. Pesole G, Lotti M, Alberghina L, Saccone C. 1995. Evolutionary origin of nonuniversal CUGSer codon in some Candida species as inferred from a molecular phylogeny. Genetics 141: 903-907.
46. Philpott CC. 2006. Iron uptake in fungi: a system for every source. Biochim Biophys Acta 1763: 636-645.
47. Prasad T, Chandra A, Mukhopadhyay CK, Prasad R. 2006. Unexpected link between iron and drug resistance of Candida spp.: iron depletion enhances membrane fluidity and drug diffusion, leading to drug-susceptible cells. Antimicrob Agents Chemother 50: 3597-3606.
48. Ramanan N, Wang Y. 2000. A high-affinity iron permease essential for Candida albicans virulence. Science 288: 1062-1064.
49. Rustici G, van Bakel H, Lackner DH, et al. 2007. Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study. Genome Biol 8(5): R73.1-R73.16.
50. Rutherford JC, Jaron S, Ray E, Brown PO, Winge DR. 2001. A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci USA 98: 14322-14327.
51. Santos R, Buisson N, Knight S, et al. 2003. Haemin uptake and use as an iron source by Candida albicans: role of CaHMX1-encoded haem oxygenase. Microbiology 149: 579-588.
52. Schaible UE, Kaufmann SH. 2004. Iron and microbial infection. Nat Rev Microbiol 2: 946-953.
53. Skaar EP, Humayun M, Bae T, DeBord KL, Schneewind O. 2004. Iron-source preference of Staphylococcus aureus infections. Science 305: 1626-1628.
54. Stearman R, Yuan DS, Yamaguchi-Iwai Y, Klausner RD, Dancis A. 1996. A permease-oxidase complex involved in high-affinity iron uptake in yeast. Science 271: 1552-1557.
55. Thompson JM, Jones HA, Perry RD. 1999. Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization. Infect Immun 67: 3879-3892.
56. Voisard C, Wang J, McEvoy JL, Xu P, Leong SA. 1993. urbs1, a gene regulating siderophore biosynthesis in Ustilago maydis, encodes a protein similar to the erythroid transcription factor GATA-1. Mol Cell Biol 13: 7091-7100.
57. Vojtek AB, Cooper JA, Hollenberg SM. 1997. Searching for interacting proteins with the two-hybrid system II. In The Yeast Two-Hybrid System, Bartel P, Fields S (eds). Oxford University Press: New York, NY; 29-42.
58. Vojtek AB, Hollenberg SM, Cooper JA. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74: 205-214.
59. Weissman Z, Kornitzer D. 2004. A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization. Mol Microbiol 53: 1209-1220.
60. Whiteway M, Oberholzer U. 2004. Candida morphogenesis and host-pathogen interactions. Curr Opin Microbiol 7: 350-357.
61. Yamaguchi-Iwai Y, Dancis A, Klausner RD. 1995. AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae. EMBO J 14: 1231-1239.
62. Yamaguchi-Iwai Y, Stearman R, Dancis A, Klausner RD. 1996. Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J 15: 3377-3384.
63. Zaman Z, Ansari AZ, Koh SS, Young R, Ptashne M. 2001. Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression. Proc Natl Acad Sci USA 98: 2550-2554.
64. Zhou LW, Haas H, Marzluf GA. 1998. Isolation and characterization of a new gene, sre, encodes a GATA-type regulatory protein that controls iron transport in Neurospora crassa. Mol Gen Genet 259: 532-540.
65. Znaidi S, Pelletier B, Mukai Y, Labbé S. 2004. The Schizosaccharomyces pombe co-repressor Tup11 interacts with the iron-responsive transcription factor Fep1. J Biol Chem 279: 9462-9474.