Reductive iron uptake by Candida albicans: Role of copper, iron and the TUP1 regulator

Microbiology

Volumn 148, Issue 1, 2002, Pages 29-40

  Knight, Simon A B ^a   Lesuisse, Emmanuel ^a   Stearman, Robert ^a   Klausner, Richard D ^a   Dancis, Andrew ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Ferric reductase; Ferrous permease; Iron regulation; Multicopper oxidase; Siderophores

Indexed keywords

COPPER; FERROUS ION; FLAVOPROTEIN; IRON; OXIDOREDUCTASE; PERMEASE; PHENYLENEDIAMINE DERIVATIVE; REPRESSOR PROTEIN; SIDEROPHORE;

ARTICLE; BINDING AFFINITY; CANDIDA ALBICANS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPRESSION; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE LIBRARY; GENE REPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC COMPLEMENTATION; GENETIC TRANSCRIPTION; HOMEOSTASIS; IRON TRANSPORT; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; REGULATOR GENE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; VIRULENCE;

CANDIDA; CANDIDA ALBICANS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036146553     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-148-1-29     Document Type: Article

References (47)

1. Transformation of Saccharomyces cerevisiae by the lithium acetate/single-stranded carrier DNA/polyethylene glycol (LiAc/ss-DNA/PEG) protocol
2. Identification of a Candida albicans ferrichrome transporter and its characterization by expression in Saccharomyces cerevisiae
3. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake
4. Molecular biology of iron acquisition by Saccharomyces cerevisiae
5. High-efficiency transformation of yeast by electroporation
6. Homology modeling of the multicopper oxidase Fet3 gives new insights in the mechanism of iron transport in yeast
7. Control of filament formation in Candida albicans by the transcriptional repressor TUP1
8. TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans
9. Identification and characterization of TUP1-regulated genes in Candida albicans
10. Regulatory networks controlling Candida albicans morphogenesis
11. Reduction and mobilization of iron by a NAD(P)H:flavin oxidoreductase from Escherichia coli
12. Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae
13. Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport
14. The pH of the host niche controls gene expression in and virulence of Candida albicans
15. A multicopper oxidase gene from Candida albicans: Cloning, characterization and disruption
16. Transcription factors in Candida albicans - Environmental control of morphogenesis
17. Iron uptake by the yeast Pichia guilliermondii. Flavinogenesis and reductive iron assimilation are co-regulated processes
18. Intramembrane bis-heme motif for transmembrane electron transport conserved in a yeast iron reductase and the human NADPH oxidase
19. Isogenic strain construction and gene mapping in Candida albicans
20. Epidemiology of nosocomial fungal infections
21. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
22. Candida albicans CFL1 encodes a functional ferric reductase activity that can rescue a Saccharomyces cerevisiae fre1 mutant
23. Siderophore production by the pathogenic yeast, Candida albicans
24. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development
25. Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169
26. Siderophore-mediated iron uptake in Saccharomyces cerevisiae: The SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily
27. Siderophore uptake and use by the yeast Saccharomyces cerevisiae
28. Siderophore uptake by Candida albicans: Relationship to the dimorphic transition and comparison with Saccharomyces cerevisiae
29. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog
30. Nonfilamentous C. albicans mutants are avirulent
31. The glyoxylate cycle is required for fungal virulence
32. Production of a hemolytic factor by Candida albicans
33. The chemical and biological versatility of riboflavin
34. Dimorphism and virulence in Candida albicans
35. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
36. A high-affinity iron permease essential for Candida albicans virulence
37. Iron metabolism in pathogenic bacteria
38. The FRE1 ferric reductase of Saccharomyces cerevisiae is a cytochrome b similar to that of NADPH oxidase
39. Turning genes off by Ssn6-Tup1: A conserved system of transcriptional repression in eukaryotes
40. The yeast FET5 gene encodes a FET3-related multicopper oxidase implicated in iron transport
41. YIpDCE1 - An integrating plasmid for dual constitutive expression in yeast
42. A permease-oxidase complex involved in high-affinity iron uptake in yeast
43. Riboflavin 3′ - and 5′-sulfate, two novel flavins accumulating in the roots of iron-deficient sugar beet (Beta vulgaris)
44. Macrophages in resistance to candidiasis
45. Fungal infections in neutropenia: Current problems and chemotherapeutic control
46. Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast
47. The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake