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Volumn 7, Issue 10, 2007, Pages 1487-1498

The future of cell therapies in the treatment of Parkinson's disease

Author keywords

A9 neurons; Carotid bodies; Cell therapy; Embryonic stem cells; Fetal ventral mesencephalon tissue; Graft induced dyskinesia; Levodopa induced dyskinesia; Mesenchymal stem cells; Parkinson's disease

Indexed keywords

CELL REGENERATION; CELL SURVIVAL; CELL THERAPY; CLINICAL TRIAL; DYSKINESIA; EMBRYONIC STEM CELL; HUMAN; IN VITRO STUDY; MESENCEPHALON; MESENCHYMAL STEM CELL; NERVE CELL; NONHUMAN; PARKINSON DISEASE; REVIEW; ALLOTRANSPLANTATION; ANIMAL; BRAIN TRANSPLANTATION; DISEASE MODEL; FETAL TISSUE TRANSPLANTATION; MESENCHYMAL STEM CELL TRANSPLANTATION; NERVE REGENERATION; PATHOPHYSIOLOGY; PRENATAL DEVELOPMENT; TRANSPLANTATION; TREATMENT OUTCOME;

EID: 35348920028     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.7.10.1487     Document Type: Review
Times cited : (20)

References (88)
  • 1
    • 0042922748 scopus 로고    scopus 로고
    • Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson disease
    • KLEINER-FISMAN G, FISMAN DN, SIME E, SAINT-CYR JA, LOZANO AM, LANG AE: Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson disease. J Neurosurg. (2003) 99(3):489-495.
    • (2003) J Neurosurg , vol.99 , Issue.3 , pp. 489-495
    • KLEINER-FISMAN, G.1    FISMAN, D.N.2    SIME, E.3    SAINT-CYR, J.A.4    LOZANO, A.M.5    LANG, A.E.6
  • 2
    • 13144282676 scopus 로고    scopus 로고
    • Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: A two-year outcome study
    • PATEL NK, BUNNAGE M, PLAHA P, SVENDSEN CN, HEYWOOD P, GILL SS: Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Ann. Neurol. (2005) 57(2):298-302.
    • (2005) Ann. Neurol , vol.57 , Issue.2 , pp. 298-302
    • PATEL, N.K.1    BUNNAGE, M.2    PLAHA, P.3    SVENDSEN, C.N.4    HEYWOOD, P.5    GILL, S.S.6
  • 3
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • GILL SS, PATEL NK, HOTTON GR et al.: Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat. Med. (2003) 9(5):589-595.
    • (2003) Nat. Med , vol.9 , Issue.5 , pp. 589-595
    • GILL, S.S.1    PATEL, N.K.2    HOTTON, G.R.3
  • 4
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson's disease
    • LANG AE, GILL S, PATEL NK et al.: Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson's disease. Ann. Neurol. (2006) 59(3):459-466.
    • (2006) Ann. Neurol , vol.59 , Issue.3 , pp. 459-466
    • LANG, A.E.1    GILL, S.2    PATEL, N.K.3
  • 5
    • 0018778418 scopus 로고
    • Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system
    • PERLOW MJ, FREED WJ, HOFFER BJ, SEIGER A, OLSON L, WYATT RJ: Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science (1979) 204(4393):643-647.
    • (1979) Science , vol.204 , Issue.4393 , pp. 643-647
    • PERLOW, M.J.1    FREED, W.J.2    HOFFER, B.J.3    SEIGER, A.4    OLSON, L.5    WYATT, R.J.6
  • 6
    • 0018695489 scopus 로고
    • Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants
    • BJÖRKLUND A, STENEVI U: Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. (1979) 177(3):555-560.
    • (1979) Brain Res , vol.177 , Issue.3 , pp. 555-560
    • BJÖRKLUND, A.1    STENEVI, U.2
  • 7
    • 0018825573 scopus 로고
    • Reinnervation of the denervated striatum by substantia nigra transplants: Functional consequences as revealed by pharmacological and sensorimotor testing
    • BJÖRKLUND A, DUNNETT SB, STENEVI U, LEWIS ME, IVERSEN SD: Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res. (1980) 199(2):307-333.
    • (1980) Brain Res , vol.199 , Issue.2 , pp. 307-333
    • BJÖRKLUND, A.1    DUNNETT, S.B.2    STENEVI, U.3    LEWIS, M.E.4    IVERSEN, S.D.5
  • 8
    • 0023117623 scopus 로고
    • Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease
    • BRUNDIN P, NILSSON OG, STRECKER RE, LINDVALL O, ASTEDT B, BJÖRKLUND A: Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease. Exp. Brain Res. (1986) 65(1):235-240.
    • (1986) Exp. Brain Res , vol.65 , Issue.1 , pp. 235-240
    • BRUNDIN, P.1    NILSSON, O.G.2    STRECKER, R.E.3    LINDVALL, O.4    ASTEDT, B.5    BJÖRKLUND, A.6
  • 9
    • 0026701417 scopus 로고
    • Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats
    • WICTORIN K, BRUNDIN P, SAUER H, LINDVALL O, BJÖRKLUND A: Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats. J. Comp. Neurol (1992) 323(4):475-494.
    • (1992) J. Comp. Neurol , vol.323 , Issue.4 , pp. 475-494
    • WICTORIN, K.1    BRUNDIN, P.2    SAUER, H.3    LINDVALL, O.4    BJÖRKLUND, A.5
  • 10
    • 0026443974 scopus 로고
    • Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease
    • FREED CR, BREEZE RE, ROSENBERG NL et al.: Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. N. Engl. J. Med (1992) 327(22):1549-1555.
    • (1992) N. Engl. J. Med , vol.327 , Issue.22 , pp. 1549-1555
    • FREED, C.R.1    BREEZE, R.E.2    ROSENBERG, N.L.3
  • 11
    • 0032692348 scopus 로고    scopus 로고
    • Sequential bilateral transplantation in Parkinson's disease: Effects of the second graft
    • HAGELL P, SCHRAG A, PICCINI P et al.: Sequential bilateral transplantation in Parkinson's disease: effects of the second graft. Brain (1999) 122:1121-1132.
    • (1999) Brain , vol.122 , pp. 1121-1132
    • HAGELL, P.1    SCHRAG, A.2    PICCINI, P.3
  • 12
    • 0033053030 scopus 로고    scopus 로고
    • Long-term evaluation of bilateral fetal nigral transplantation in Parkinson's disease
    • HAUSER RA, FREEMAN TB, SNOW BJ et al.: Long-term evaluation of bilateral fetal nigral transplantation in Parkinson's disease. Arch. Neurol. (1999) 56:179-187.
    • (1999) Arch. Neurol , vol.56 , pp. 179-187
    • HAUSER, R.A.1    FREEMAN, T.B.2    SNOW, B.J.3
  • 13
    • 0033934144 scopus 로고    scopus 로고
    • Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease
    • BRUNDIN P, POGARELL O, HAGELL P et al.: Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease. Brain (2000) 123(Part 7):1380-1390.
    • (2000) Brain , vol.123 , Issue.PART 7 , pp. 1380-1390
    • BRUNDIN, P.1    POGARELL, O.2    HAGELL, P.3
  • 14
    • 0035826089 scopus 로고    scopus 로고
    • FREED CR, GREENE PE, BREEZE RE et al.: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Eng. J. Med. (2001) 344(10):710-719. • First double-blind, placebo-controlled clinical trial published using human fetal VM in PD patients, showing significant clinical recovery only in patients aged > 60 years compared to the control group.
    • FREED CR, GREENE PE, BREEZE RE et al.: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Eng. J. Med. (2001) 344(10):710-719. • First double-blind, placebo-controlled clinical trial published using human fetal VM in PD patients, showing significant clinical recovery only in patients aged > 60 years compared to the control group.
  • 15
    • 0042837887 scopus 로고    scopus 로고
    • OLANOW CW, GOETZ CG, KORDOWER JH et al.: A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann. Neurol. (2003) 54(3):403-414. • Second double-blind, placebo-controlled clinical trial using human fetal VM in PD patients, with no significant overall recovery reported, although suggesting that less severe patients did better after grafting.
    • OLANOW CW, GOETZ CG, KORDOWER JH et al.: A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann. Neurol. (2003) 54(3):403-414. • Second double-blind, placebo-controlled clinical trial using human fetal VM in PD patients, with no significant overall recovery reported, although suggesting that less severe patients did better after grafting.
  • 16
    • 28544441892 scopus 로고    scopus 로고
    • PICCINI P, PAVESE N, HAGELL P et al.: Factors affecting the clinical outcome after neural transplantation in Parkinson's disease. Brain (2005) 128(Part 12):2977-2986. • An article investigating what factors may influence the success of VM allografting using flurodopa PET scanning. The results suggested that dopamine changes outside the dorsal striatum may be associated with worse outcomes following grafting.
    • PICCINI P, PAVESE N, HAGELL P et al.: Factors affecting the clinical outcome after neural transplantation in Parkinson's disease. Brain (2005) 128(Part 12):2977-2986. • An article investigating what factors may influence the success of VM allografting using flurodopa PET scanning. The results suggested that dopamine changes outside the dorsal striatum may be associated with worse outcomes following grafting.
  • 17
    • 21944436225 scopus 로고    scopus 로고
    • Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease
    • MENDEZ I, SANCHEZ-PERNAUTE R, COOPER O et al.: Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain (2005) 128(Part 7):1498-1510.
    • (2005) Brain , vol.128 , Issue.PART 7 , pp. 1498-1510
    • MENDEZ, I.1    SANCHEZ-PERNAUTE, R.2    COOPER, O.3
  • 18
    • 0029944565 scopus 로고    scopus 로고
    • Functional and anatomical reconstruction of the 6-hydroxydopamine lesioned nigrostriatal system of the adult rat
    • BRECKNELL JE, HAQUE NS, DU JS et al.: Functional and anatomical reconstruction of the 6-hydroxydopamine lesioned nigrostriatal system of the adult rat. Neuroscience (1996a) 71(4):913-925.
    • (1996) Neuroscience , vol.71 , Issue.4 , pp. 913-925
    • BRECKNELL, J.E.1    HAQUE, N.S.2    DU, J.S.3
  • 19
    • 0035914209 scopus 로고    scopus 로고
    • GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DAergic neurons
    • NAKAJIMA K, HIDA H, SHIMANO Y et al.: GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DAergic neurons. Brain Res. (2001) 916(1-2):76-84.
    • (2001) Brain Res , vol.916 , Issue.1-2 , pp. 76-84
    • NAKAJIMA, K.1    HIDA, H.2    SHIMANO, Y.3
  • 20
    • 0025006731 scopus 로고
    • Enhanced survival of cultured dopamine neurons by treatment with soluble extracts from chemically deafferentiated striatum of adult rat brain
    • NIIJIMA K, ARAKI M, OGAWA M et al.: Enhanced survival of cultured dopamine neurons by treatment with soluble extracts from chemically deafferentiated striatum of adult rat brain. Brain Res. (1990) 528(1):151-154.
    • (1990) Brain Res , vol.528 , Issue.1 , pp. 151-154
    • NIIJIMA, K.1    ARAKI, M.2    OGAWA, M.3
  • 21
    • 0034730862 scopus 로고    scopus 로고
    • Striatal extracts promote the survival and phenotypic expression of rat fetal dopaminergic neurons in vitro
    • ZHOU J, SHEN Y, TANG Z, XU L, BRADFORD HF, YU Y: Striatal extracts promote the survival and phenotypic expression of rat fetal dopaminergic neurons in vitro. Neurosci. Lett. (2000) 292(1):5-8.
    • (2000) Neurosci. Lett , vol.292 , Issue.1 , pp. 5-8
    • ZHOU, J.1    SHEN, Y.2    TANG, Z.3    XU, L.4    BRADFORD, H.F.5    YU, Y.6
  • 22
    • 0028912424 scopus 로고
    • Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat
    • CHOI-LUNDBERG DL, BOHN MC: Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Brain Res. Dev. Brain Res. (1995) 85(1):80-88.
    • (1995) Brain Res. Dev. Brain Res , vol.85 , Issue.1 , pp. 80-88
    • CHOI-LUNDBERG, D.L.1    BOHN, M.C.2
  • 23
    • 0034959811 scopus 로고    scopus 로고
    • Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain
    • CHAUHAN NB, SIEGEL GJ, LEE JM: Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain. J. Chem. Neuroanat. (2001) 21(4):277-288.
    • (2001) J. Chem. Neuroanat , vol.21 , Issue.4 , pp. 277-288
    • CHAUHAN, N.B.1    SIEGEL, G.J.2    LEE, J.M.3
  • 24
    • 0033962594 scopus 로고    scopus 로고
    • Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons
    • SAWADA H, IBI M, KIHARA T et al.: Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons. J. Neurochem. (2000) 74(3):1175-1184.
    • (2000) J. Neurochem , vol.74 , Issue.3 , pp. 1175-1184
    • SAWADA, H.1    IBI, M.2    KIHARA, T.3
  • 25
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • KORDOWER JH, EMBORG ME, BLOCH J et al.: Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (2000) 290(5492):767-773.
    • (2000) Science , vol.290 , Issue.5492 , pp. 767-773
    • KORDOWER, J.H.1    EMBORG, M.E.2    BLOCH, J.3
  • 26
    • 0343517507 scopus 로고    scopus 로고
    • Lentiviral vectors as a gene delivery system in the mouse midbrain: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF
    • BENSADOUN JC, DÉGLON N, TSENG JL, RIDET JL, ZURN AD, AEBISCHER P: Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF. Exp. Neurol. (2000) 164(1):15-24.
    • (2000) Exp. Neurol , vol.164 , Issue.1 , pp. 15-24
    • BENSADOUN, J.C.1    DÉGLON, N.2    TSENG, J.L.3    RIDET, J.L.4    ZURN, A.D.5    AEBISCHER, P.6
  • 27
    • 13844280470 scopus 로고    scopus 로고
    • Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson's disease
    • YASUHARA T, SHINGO T, MURAOKA K et al.: Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson's disease. J. Neurosurg. (2005) 102:80-89.
    • (2005) J. Neurosurg , vol.102 , pp. 80-89
    • YASUHARA, T.1    SHINGO, T.2    MURAOKA, K.3
  • 28
    • 0031905828 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells
    • APOSTOLIDES C, SANFORD E, HONG M, MENDEZ I: Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells. Neuroscience (1998) 83(2):363-372.
    • (1998) Neuroscience , vol.83 , Issue.2 , pp. 363-372
    • APOSTOLIDES, C.1    SANFORD, E.2    HONG, M.3    MENDEZ, I.4
  • 29
    • 0037405705 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor-supplemented hibernation of fetal ventral mesencephalic neurons for transplantation in Parkinson disease: Long-term storage
    • HEBB AO, HEBB K, RAMACHANDRAN AC, MENDEZ I: Glial cell line-derived neurotrophic factor-supplemented hibernation of fetal ventral mesencephalic neurons for transplantation in Parkinson disease: long-term storage. J. Neurosurg. (2003) 98(5):1078-1083.
    • (2003) J. Neurosurg , vol.98 , Issue.5 , pp. 1078-1083
    • HEBB, A.O.1    HEBB, K.2    RAMACHANDRAN, A.C.3    MENDEZ, I.4
  • 30
    • 0036435612 scopus 로고    scopus 로고
    • Lipid-mediated glial cell line-derived neurotrophic factor gene transfer to cultured porcine ventral mesencephalic tissue
    • BAUER M, MEYER M, BREVIG T et al.: Lipid-mediated glial cell line-derived neurotrophic factor gene transfer to cultured porcine ventral mesencephalic tissue. Exp. Neurol. (2002) 177(1):40-49.
    • (2002) Exp. Neurol , vol.177 , Issue.1 , pp. 40-49
    • BAUER, M.1    MEYER, M.2    BREVIG, T.3
  • 31
    • 0037106156 scopus 로고    scopus 로고
    • Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF-producing cells in a rat model of Parkinson's disease
    • SHINGO T, DATE I, YOSHIDA H, OHMOTO T: Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF-producing cells in a rat model of Parkinson's disease. J. Neurosci. Res. (2002) 69(6):946-954.
    • (2002) J. Neurosci. Res , vol.69 , Issue.6 , pp. 946-954
    • SHINGO, T.1    DATE, I.2    YOSHIDA, H.3    OHMOTO, T.4
  • 32
    • 0037435511 scopus 로고    scopus 로고
    • ICV GDNF STUDY GROUP: Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor, randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    • NUTT JG, BURCHIEL KJ, COMELLA CL et al.; ICV GDNF STUDY GROUP: Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor, randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology (2003) 60(1):69-73.
    • (2003) Neurology , vol.60 , Issue.1 , pp. 69-73
    • NUTT, J.G.1    BURCHIEL, K.J.2    COMELLA, C.L.3
  • 33
    • 0032850453 scopus 로고    scopus 로고
    • Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
    • KORDOWER JH, PALFI S, CHEN EY et al.: Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann. Neurol. (1999) 46:419-424.
    • (1999) Ann. Neurol , vol.46 , pp. 419-424
    • KORDOWER, J.H.1    PALFI, S.2    CHEN, E.Y.3
  • 34
    • 0028942936 scopus 로고
    • Repulsive and inhibitory signals
    • KEYNES RJ, COOK GM: Repulsive and inhibitory signals. Curr. Opin. Neurobiol. (1995) 5(1):75-82.
    • (1995) Curr. Opin. Neurobiol , vol.5 , Issue.1 , pp. 75-82
    • KEYNES, R.J.1    COOK, G.M.2
  • 35
    • 0030248550 scopus 로고    scopus 로고
    • The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum
    • BARKER RA, DUNNETT SB, FAISSNER A, FAWCETT JW: The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum. Exp. Neurol. (1996) 141(1):79-93.
    • (1996) Exp. Neurol , vol.141 , Issue.1 , pp. 79-93
    • BARKER, R.A.1    DUNNETT, S.B.2    FAISSNER, A.3    FAWCETT, J.W.4
  • 36
    • 0033559401 scopus 로고    scopus 로고
    • A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra
    • WILBY MJ, SINCLAIR SR, MUIR EM et al.: A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra. J. Neurosci. (1999) 19(6):2301-2312.
    • (1999) J. Neurosci , vol.19 , Issue.6 , pp. 2301-2312
    • WILBY, M.J.1    SINCLAIR, S.R.2    MUIR, E.M.3
  • 37
    • 0029910963 scopus 로고    scopus 로고
    • Constructing a new nigrostriatal pathway in the Parkinsonian model with bridged neural transplantation in substantia nigra
    • ZHOU FC, CHIANG YH, WANG Y: Constructing a new nigrostriatal pathway in the Parkinsonian model with bridged neural transplantation in substantia nigra. J. Neurosci. (1996) 16(21):6965-6974.
    • (1996) J. Neurosci , vol.16 , Issue.21 , pp. 6965-6974
    • ZHOU, F.C.1    CHIANG, Y.H.2    WANG, Y.3
  • 38
    • 0033054208 scopus 로고    scopus 로고
    • Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants
    • WINKLER C, BENTLAGE C, NIKKHAH G, SAMII M, BJÖRKLUND A: Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants. Exp. Neurol. (1999) 155(2):165-186.
    • (1999) Exp. Neurol , vol.155 , Issue.2 , pp. 165-186
    • WINKLER, C.1    BENTLAGE, C.2    NIKKHAH, G.3    SAMII, M.4    BJÖRKLUND, A.5
  • 39
    • 0030564948 scopus 로고    scopus 로고
    • Bridge grafts of fibroblast growth factor-4-secreting schwannoma cells promote functional axonal regeneration in the nigrostriatal pathway of the adult rat
    • BRECKNELL JE, DU JS, MUIR E et al.: Bridge grafts of fibroblast growth factor-4-secreting schwannoma cells promote functional axonal regeneration in the nigrostriatal pathway of the adult rat. Neuroscience (1996b) 74(3):775-784.
    • (1996) Neuroscience , vol.74 , Issue.3 , pp. 775-784
    • BRECKNELL, J.E.1    DU JS, M.E.2
  • 40
    • 0001989283 scopus 로고
    • Evidence for the existence of monoamine-containing neurons in the central nervous system: Demonstration of monoamines in cell bodies of brainstem neurons
    • DAHLSTROM A, FUXE K: Evidence for the existence of monoamine-containing neurons in the central nervous system: demonstration of monoamines in cell bodies of brainstem neurons. Acta Physiol. Scand. (1964) (Suppl. 232):1-55.
    • (1964) Acta Physiol. Scand , Issue.SUPPL. 232 , pp. 1-55
    • DAHLSTROM, A.1    FUXE, K.2
  • 41
    • 0026036920 scopus 로고
    • The human substantia nigra and ventral tegmental area. A neuroanatomical study with notes on aging and aging disease
    • VAN DOMBURG PH, TEN DONKELAAR HJ: The human substantia nigra and ventral tegmental area. A neuroanatomical study with notes on aging and aging disease. Adv. Anatomy Embryol. Cell Biol. (1991) 121:1-132.
    • (1991) Adv. Anatomy Embryol. Cell Biol , vol.121 , pp. 1-132
    • VAN DOMBURG PH, T.E.N.1    DONKELAAR, H.J.2
  • 43
    • 0038614833 scopus 로고    scopus 로고
    • Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
    • VAN DEN MUNCKHOF P, LUK KC, STE-MARIE L et al.: Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development (2003) 130:2535-2542.
    • (2003) Development , vol.130 , pp. 2535-2542
    • VAN DEN MUNCKHOF, P.1    LUK, K.C.2    STE-MARIE, L.3
  • 44
    • 1642534464 scopus 로고    scopus 로고
    • Making connections: The development of mesencephalic dopaminergic neurons
    • RIDDLE R, POLLOCK JD: Making connections: the development of mesencephalic dopaminergic neurons. Dev. Brain Res. (2003) 147:3-21.
    • (2003) Dev. Brain Res , vol.147 , pp. 3-21
    • RIDDLE, R.1    POLLOCK, J.D.2
  • 45
    • 13444256259 scopus 로고    scopus 로고
    • The homeodomain transcription factor Pitx3 facilitates differentation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons
    • CHUNG S, HEDLUND E, HWANG M et al.: The homeodomain transcription factor Pitx3 facilitates differentation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons. Mol. Cell. Neurosci. (2005) 28:241-252.
    • (2005) Mol. Cell. Neurosci , vol.28 , pp. 241-252
    • CHUNG, S.1    HEDLUND, E.2    HWANG, M.3
  • 46
    • 21844454972 scopus 로고    scopus 로고
    • THOMPSON L, BARRAUD P, ANDERSSON E, KIRIK D, BJÖRKLUND A: Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. J. Neurosci. (2005) 25(27):6467-6477. • The first paper that clearly addressed the distinctive morphology and reinnervation pattern of A9 dopaminergic neurons in VM transplants in rats.
    • THOMPSON L, BARRAUD P, ANDERSSON E, KIRIK D, BJÖRKLUND A: Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. J. Neurosci. (2005) 25(27):6467-6477. • The first paper that clearly addressed the distinctive morphology and reinnervation pattern of A9 dopaminergic neurons in VM transplants in rats.
  • 47
    • 33847265379 scopus 로고    scopus 로고
    • The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias
    • KUAN WL, LIN R, TYERS P, BARKER RA: The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias. Neurobiol Dis. (2007) 25(3):594-608.
    • (2007) Neurobiol Dis , vol.25 , Issue.3 , pp. 594-608
    • KUAN, W.L.1    LIN, R.2    TYERS, P.3    BARKER, R.A.4
  • 48
    • 0035692955 scopus 로고    scopus 로고
    • Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat
    • MOORE AE, CICCHETTI F, HENNEN J, ISACSON O: Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat. Exp. Neurol. (2001) 172:363-376.
    • (2001) Exp. Neurol , vol.172 , pp. 363-376
    • MOORE, A.E.1    CICCHETTI, F.2    HENNEN, J.3    ISACSON, O.4
  • 49
    • 0025298139 scopus 로고
    • Primate models of movement disorders of basal ganglia origin
    • DELONG MR: Primate models of movement disorders of basal ganglia origin. Trends Neurosci. (1990) 13:281-285.
    • (1990) Trends Neurosci , vol.13 , pp. 281-285
    • DELONG, M.R.1
  • 50
    • 0035104574 scopus 로고    scopus 로고
    • Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alteration of pallidal neurons in the MPTP-treated monkey
    • BORAUD T, BEZARD E, BIOULAC B, GROSS CE: Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alteration of pallidal neurons in the MPTP-treated monkey. Brain (2001) 124:546-557.
    • (2001) Brain , vol.124 , pp. 546-557
    • BORAUD, T.1    BEZARD, E.2    BIOULAC, B.3    GROSS, C.E.4
  • 51
    • 0038579160 scopus 로고    scopus 로고
    • Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function
    • BEZARD E, FERRY S, MACH U et al.: Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. Nat. Med. (2003) 9(6):762-767.
    • (2003) Nat. Med , vol.9 , Issue.6 , pp. 762-767
    • BEZARD, E.1    FERRY, S.2    MACH, U.3
  • 52
    • 0036307190 scopus 로고    scopus 로고
    • HAGELL P, PICCINI P, BJÖRKLUND A et al.: Dyskinesia following neural transplantation in Parkinson's disease. Nat. Neurosci. (2002) 5(7):627-628. • This short paper undertakes a retrospective analysis of VM allografting in patients with PD and LID development.
    • HAGELL P, PICCINI P, BJÖRKLUND A et al.: Dyskinesia following neural transplantation in Parkinson's disease. Nat. Neurosci. (2002) 5(7):627-628. • This short paper undertakes a retrospective analysis of VM allografting in patients with PD and LID development.
  • 53
    • 0036830588 scopus 로고    scopus 로고
    • Dyskinesia after fetal cell transplantation for parkinsonism: A PET study
    • MA Y, FEIGIN A, DHAWAN V et al.: Dyskinesia after fetal cell transplantation for parkinsonism: a PET study. Ann. Neurol. (2002) 52:628-634.
    • (2002) Ann. Neurol , vol.52 , pp. 628-634
    • MA, Y.1    FEIGIN, A.2    DHAWAN, V.3
  • 54
    • 0033428178 scopus 로고    scopus 로고
    • Striatal FosB expression is casually linked with 1-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease
    • ANDERSSON M, HILBERTSON A, CENCI MA: Striatal FosB expression is casually linked with 1-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease. Neurobiol. Dis. (1999) 6:461-474.
    • (1999) Neurobiol. Dis , vol.6 , pp. 461-474
    • ANDERSSON, M.1    HILBERTSON, A.2    CENCI, M.A.3
  • 55
    • 33244459813 scopus 로고    scopus 로고
    • Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia
    • CARLSSON T, WINKLER C, LUNDBLAD M, CENCI MA, BJÖRKLUND A, KIRIK D: Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia. Neurobiol. Dis. (2006) 21(3):657-668.
    • (2006) Neurobiol. Dis , vol.21 , Issue.3 , pp. 657-668
    • CARLSSON, T.1    WINKLER, C.2    LUNDBLAD, M.3    CENCI, M.A.4    BJÖRKLUND, A.5    KIRIK, D.6
  • 56
    • 33646140789 scopus 로고    scopus 로고
    • The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat
    • LANE EL, WINKLER C, BRUNDIN P, CENCI MA: The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat. Neurobiol. Dis. (2006) 22(2):334-345.
    • (2006) Neurobiol. Dis , vol.22 , Issue.2 , pp. 334-345
    • LANE, E.L.1    WINKLER, C.2    BRUNDIN, P.3    CENCI, M.A.4
  • 57
    • 33748181034 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Properties and role in clinical bone marrow transplantation
    • LE BLANC K, RINGDEN O: Mesenchymal stem cells: properties and role in clinical bone marrow transplantation. Curr. Opin. Immunol. (2006) 18(5):586-591.
    • (2006) Curr. Opin. Immunol , vol.18 , Issue.5 , pp. 586-591
    • LE BLANC, K.1    RINGDEN, O.2
  • 58
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • PITTENGER MF, MACKAY AM, BECK SC et al.: Multilineage potential of adult human mesenchymal stem cells. Science (1999) 284(5411):143- 147.
    • (1999) Science , vol.284 , Issue.5411 , pp. 143-147
    • PITTENGER, M.F.1    MACKAY, A.M.2    BECK, S.C.3
  • 59
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • JIANG Y, JAHAGIRDAR BN, REINHARDT RL et al.: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 418(6893):41-49.
    • (2002) Nature , vol.418 , Issue.6893 , pp. 41-49
    • JIANG, Y.1    JAHAGIRDAR, B.N.2    REINHARDT, R.L.3
  • 60
    • 33747773671 scopus 로고    scopus 로고
    • Adult hippocampus derived soluble factors induce a neuronal-like phenotype in mesenchymal stem cells
    • RIVERA FJ, SIERRALTA WD, MINGUELL JJ, AIGNER L: Adult hippocampus derived soluble factors induce a neuronal-like phenotype in mesenchymal stem cells. Neurosci. Lett. (2006) 406(1-2):49-54.
    • (2006) Neurosci. Lett , vol.406 , Issue.1-2 , pp. 49-54
    • RIVERA, F.J.1    SIERRALTA, W.D.2    MINGUELL, J.J.3    AIGNER, L.4
  • 61
    • 33751197034 scopus 로고    scopus 로고
    • Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cells
    • KIM S, HONMOU O, KATO K et al.: Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cells. Brain Res. (2006) 1123(1):27-33.
    • (2006) Brain Res , vol.1123 , Issue.1 , pp. 27-33
    • KIM, S.1    HONMOU, O.2    KATO, K.3
  • 62
    • 3042769428 scopus 로고    scopus 로고
    • DEZAWA M, KANNO H, HOSHINO M et al.: Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J. Clin. Investig. (2004) 113(12):1701-1710. • One of the first papers showing that bone marrow stromal cell-derived neuronal cells may be a promising source for PD neural autotransplantation.
    • DEZAWA M, KANNO H, HOSHINO M et al.: Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J. Clin. Investig. (2004) 113(12):1701-1710. • One of the first papers showing that bone marrow stromal cell-derived neuronal cells may be a promising source for PD neural autotransplantation.
  • 63
    • 0242584006 scopus 로고    scopus 로고
    • Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    • ALVAREZ-DOLADO M, GARCIA-VERDUGO JM, FIKE JR et al.: Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature (2003) 425(6961):968-973.
    • (2003) Nature , vol.425 , Issue.6961 , pp. 968-973
    • ALVAREZ-DOLADO, M.1    GARCIA-VERDUGO, J.M.2    FIKE, J.R.3
  • 64
    • 33845885144 scopus 로고    scopus 로고
    • Immune regulation by mesenchymal stem cells: Two sides to the coin
    • STAGG J: Immune regulation by mesenchymal stem cells: two sides to the coin. Tissue Antigens (2007) 69(1):1-9.
    • (2007) Tissue Antigens , vol.69 , Issue.1 , pp. 1-9
    • STAGG, J.1
  • 65
    • 0037183512 scopus 로고    scopus 로고
    • Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery
    • LI Y, CHEN J, CHEN XG et al.: Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology (2002) 59(4):514-523.
    • (2002) Neurology , vol.59 , Issue.4 , pp. 514-523
    • LI, Y.1    CHEN, J.2    CHEN, X.G.3
  • 66
    • 0021751184 scopus 로고
    • A morphometric study of the carotid body in chronically hypoxic rats
    • MCGREGOR KH, GIL J, LAHIRI S: A morphometric study of the carotid body in chronically hypoxic rats. J. Appl. Physiol. (1984) 57:1430-1438.
    • (1984) J. Appl. Physiol , vol.57 , pp. 1430-1438
    • MCGREGOR, K.H.1    GIL, J.2    LAHIRI, S.3
  • 67
    • 0032005461 scopus 로고    scopus 로고
    • Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates
    • ESPEJO EF, MONTORO RJ, ARMENGOL JA, LÓPEZ-BARNEO J: Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates. Neuron (1998) 20(2):197-206.
    • (1998) Neuron , vol.20 , Issue.2 , pp. 197-206
    • ESPEJO, E.F.1    MONTORO, R.J.2    ARMENGOL, J.A.3    LÓPEZ-BARNEO, J.4
  • 68
    • 0037221429 scopus 로고    scopus 로고
    • Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted Parkinsonian rats
    • TOLEDO-ARAL JJ, MÉNDEZ-FERRER S, PARDAL R, ECHEVARRÍA M, LÓPEZ-BARNEO J: Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted Parkinsonian rats. J. Neurosci. (2003) 23(1):141-148.
    • (2003) J. Neurosci , vol.23 , Issue.1 , pp. 141-148
    • TOLEDO-ARAL, J.J.1    MÉNDEZ-FERRER, S.2    PARDAL, R.3    ECHEVARRÍA, M.4    LÓPEZ-BARNEO, J.5
  • 69
    • 0342308802 scopus 로고    scopus 로고
    • Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen
    • LUQUIN MR, MONTORO RJ, GUILLEN J et al.: Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen. Neuron (1999) 22(4):743-750.
    • (1999) Neuron , vol.22 , Issue.4 , pp. 743-750
    • LUQUIN, M.R.1    MONTORO, R.J.2    GUILLEN, J.3
  • 71
    • 33747355985 scopus 로고    scopus 로고
    • Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: Results from an in vitro model system
    • MCKAY BS, GOODMAN B, FALK T, SHERMAN SJ: Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system. Exp. Neurol. (2006) 201(1):234-243.
    • (2006) Exp. Neurol , vol.201 , Issue.1 , pp. 234-243
    • MCKAY, B.S.1    GOODMAN, B.2    FALK, T.3    SHERMAN, S.J.4
  • 72
    • 0035998724 scopus 로고    scopus 로고
    • Striatal xenotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response
    • SUBRAMANIAN T, MARCHIONINI D, POTTER EM, CORNFELDT ML: Striatal xenotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response. Cell Transplant. (2002) 11(3):207-214.
    • (2002) Cell Transplant , vol.11 , Issue.3 , pp. 207-214
    • SUBRAMANIAN, T.1    MARCHIONINI, D.2    POTTER, E.M.3    CORNFELDT, M.L.4
  • 73
    • 4544226149 scopus 로고    scopus 로고
    • PET imaging of implanted human retinal pigment epithelial cells in the MPTP-induced primate model of Parkinson's disease
    • DOUDET DJ, CORNFELDT ML, HONEY CR, SCHWEIKERT AW, ALLEN RC: PET imaging of implanted human retinal pigment epithelial cells in the MPTP-induced primate model of Parkinson's disease. Exp. Neurol. (2004) 189(2):361-368.
    • (2004) Exp. Neurol , vol.189 , Issue.2 , pp. 361-368
    • DOUDET, D.J.1    CORNFELDT, M.L.2    HONEY, C.R.3    SCHWEIKERT, A.W.4    ALLEN, R.C.5
  • 74
    • 28944447738 scopus 로고    scopus 로고
    • Intrastriatal implantation of human retinal pigment epithelial cells attached to microcarriers in advanced Parkinson disease
    • STOVER NP, BAKAY RA, SUBRAMANIAN T et al.: Intrastriatal implantation of human retinal pigment epithelial cells attached to microcarriers in advanced Parkinson disease. Arch. Neurol. (2005) 62(12):1833- 1837.
    • (2005) Arch. Neurol , vol.62 , Issue.12 , pp. 1833-1837
    • STOVER, N.P.1    BAKAY, R.A.2    SUBRAMANIAN, T.3
  • 75
    • 0033638174 scopus 로고    scopus 로고
    • Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
    • KAWASAKI H, MIZUSEKI K, NISHIKAWA S et al.: Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron (2000) 28(1):31-40.
    • (2000) Neuron , vol.28 , Issue.1 , pp. 31-40
    • KAWASAKI, H.1    MIZUSEKI, K.2    NISHIKAWA, S.3
  • 76
    • 85047689727 scopus 로고    scopus 로고
    • Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model
    • TAKAGI Y, TAKAHASHI J, SAIKI H et al.: Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J. Clin. Invest. (2005) 115(1):102-109.
    • (2005) J. Clin. Invest , vol.115 , Issue.1 , pp. 102-109
    • TAKAGI, Y.1    TAKAHASHI, J.2    SAIKI, H.3
  • 77
    • 0034044317 scopus 로고    scopus 로고
    • Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
    • LEE SH, LUMELSKY N, STUDER L, AUERBACH JM, MCKAY RD: Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotechnol. (2000) 18(6):675-679.
    • (2000) Nat. Biotechnol , vol.18 , Issue.6 , pp. 675-679
    • LEE, S.H.1    LUMELSKY, N.2    STUDER, L.3    AUERBACH, J.M.4    MCKAY, R.D.5
  • 78
    • 0037019332 scopus 로고    scopus 로고
    • Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
    • KIM JH, AUERBACH JM, RODRIGUEZ-GOMEZ JA et al.: Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature (2002) 418(6893):50-56.
    • (2002) Nature , vol.418 , Issue.6893 , pp. 50-56
    • KIM, J.H.1    AUERBACH, J.M.2    RODRIGUEZ-GOMEZ, J.A.3
  • 79
    • 0035203881 scopus 로고    scopus 로고
    • Neural progenitors from human embryonic stem cells
    • REUBINOFF BE, ITSYKSON P, TURETSKY T et al.: Neural progenitors from human embryonic stem cells. Nat. Biotechnol. (2001) 19(12):1134-1140.
    • (2001) Nat. Biotechnol , vol.19 , Issue.12 , pp. 1134-1140
    • REUBINOFF, B.E.1    ITSYKSON, P.2    TURETSKY, T.3
  • 80
    • 0035200623 scopus 로고    scopus 로고
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    • ZHANG SC, WERNIG M, DUNCAN ID, BRÜSTLE O, THOMSON JA: In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat. Biotechnol. (2001) 19(12):1129-1133.
    • (2001) Nat. Biotechnol , vol.19 , Issue.12 , pp. 1129-1133
    • ZHANG, S.C.1    WERNIG, M.2    DUNCAN, I.D.3    BRÜSTLE, O.4    THOMSON, J.A.5
  • 81
    • 4344592974 scopus 로고    scopus 로고
    • Derivation of midbrain dopamine neurons from human embryonic stem cells
    • PERRIER AL, TABAR V, BARBERI T et al.: Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. USA (2004) 101(34):12543-12548.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.34 , pp. 12543-12548
    • PERRIER, A.L.1    TABAR, V.2    BARBERI, T.3
  • 82
    • 33750706917 scopus 로고    scopus 로고
    • ROY NS, CLEREN C, SINGH SK, YANG L, BEAL MF, GOLDMAN SA: Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat. Med. (2006) 12(11):1259-1268. • One of the first papers to demonstrate that A9 dopaminergic neurons can be derived from hESCs in the absence of products of animal origin, and moreover that these cells produce motor recovery after transplantation in a rat model of PD. This paper also highlights the fact that such transplants may contain proliferative neuroepithelial cells, which could have a tumorigenic potential different to that known already with ES cell and teratomas.
    • ROY NS, CLEREN C, SINGH SK, YANG L, BEAL MF, GOLDMAN SA: Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat. Med. (2006) 12(11):1259-1268. • One of the first papers to demonstrate that A9 dopaminergic neurons can be derived from hESCs in the absence of products of animal origin, and moreover that these cells produce motor recovery after transplantation in a rat model of PD. This paper also highlights the fact that such transplants may contain proliferative neuroepithelial cells, which could have a tumorigenic potential different to that known already with ES cell and teratomas.
  • 83
    • 0037133163 scopus 로고    scopus 로고
    • Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    • BJORKLUND LM, SÁNCHEZ-PERNAUTE R, CHUNG S et al.: Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc. Natl. Acad. Sci. USA (2002) 99(4):2344-2349.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.4 , pp. 2344-2349
    • BJORKLUND, L.M.1    SÁNCHEZ-PERNAUTE, R.2    CHUNG, S.3
  • 84
    • 33845277826 scopus 로고    scopus 로고
    • A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo
    • IACOVITTI L, DONALDSON AE, MARSHALL CE, SUON S, YANG M: A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: studies in vitro and in vivo. Brain Res. (2007) 1127(1):19-25.
    • (2007) Brain Res , vol.1127 , Issue.1 , pp. 19-25
    • IACOVITTI, L.1    DONALDSON, A.E.2    MARSHALL, C.E.3    SUON, S.4    YANG, M.5
  • 85
    • 33745001244 scopus 로고    scopus 로고
    • Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation
    • FUKUDA H, TAKAHASHI J, WATANABE K et al.: Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells (2006) 24(3):763-771.
    • (2006) Stem Cells , vol.24 , Issue.3 , pp. 763-771
    • FUKUDA, H.1    TAKAHASHI, J.2    WATANABE, K.3
  • 86
    • 33646576842 scopus 로고    scopus 로고
    • Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation
    • CHUNG S, SHIN BS, HEDLUND E et al.: Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. J. Neurochem. (2006) 97(5):1467-1480.
    • (2006) J. Neurochem , vol.97 , Issue.5 , pp. 1467-1480
    • CHUNG, S.1    SHIN, B.S.2    HEDLUND, E.3
  • 87
    • 0037147762 scopus 로고    scopus 로고
    • Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: Feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    • COLLIER TJ, SORTWELL CE, ELSWORTH JD et al.: Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease. J. Comp. Neurol. (2002) 442(4):320-330.
    • (2002) J. Comp. Neurol , vol.442 , Issue.4 , pp. 320-330
    • COLLIER, T.J.1    SORTWELL, C.E.2    ELSWORTH, J.D.3
  • 88
    • 35348977409 scopus 로고    scopus 로고
    • http://www.titanpharm.com/clinical-spheramine.html


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