A fold-back single-chain diabody format enhances the bioactivity of an anti-monkey CD3 recombinant diphtheria toxin-based immunotoxin

Protein Engineering, Design and Selection

Volumn 20, Issue 9, 2007, Pages 425-432

  Kim, Geun Bae ^a,c   Wang, Zhirui ^a   Liu, Yuan Yi ^a   Stavrou, Scott ^a   Mathias, Askale ^a   Goodwin, K Jeanine ^b   Thomas, Judith M ^b   Neville, David M ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Chung Ang University   (South Korea)

Author keywords

CD3; Diabody; FN18; Immunotoxin; Monkey

Indexed keywords

AUTOIMMUNE DISEASE THERAPY; DIABODY; IMMUNOTOXIN; MONKEY;

ANTIBODIES; DISEASES; GENES; IMMUNOLOGY; MAMMALS; TOXICITY;

BIOACTIVITY;

C207 ANTIBODY; CD3 ANTIBODY; DIPHTHERIA TOXIN; IMMUNOTOXIN; MONOMER; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; COVALENT BOND; IN VIVO STUDY; MOLECULAR INTERACTION; MUTANT; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; STEREOSPECIFICITY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD3; DIMERIZATION; DIPHTHERIA TOXIN; HAPLORHINI; IMMUNOGLOBULIN FRAGMENTS; IMMUNOTOXINS; PICHIA; PLASMIDS; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TIME FACTORS;

PICHIA PASTORIS; PRIMATES;

EID: 35348914372     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzm040     Document Type: Article

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