The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and is a strong predictor of bone strength

Bone

Volumn 41, Issue 5, 2007, Pages 804-812

  Yao, Wei ^a   Cheng, Zhiqiang ^a   Koester, Kurt J ^b   Ager, Joel W ^b   Balooch, Mehdi ^b   Pham, Aaron ^a   Chefo, Solomon ^a   Busse, Cheryl ^a   Ritchie, Robert O ^b   Lane, Nancy E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Bone mineralization; Compression strength; Intravenous bisphosphonates; OVX; Rat

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; RALOXIFENE; RISEDRONIC ACID; ZOLEDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; BONE STRENGTH; BONE TURNOVER; COMPRESSIVE STRENGTH; CONTROLLED STUDY; CRYSTALLIZATION; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; ESTROGEN DEFICIENCY; FEMALE; HIGH RESOLUTION COMPUTER TOMOGRAPHY; LUMBAR VERTEBRA; MORPHOMETRICS; NONHUMAN; OVARIECTOMY; RAT; SINGLE DRUG DOSE; TRABECULAR BONE; X RAY CRYSTALLOGRAPHY;

AGE FACTORS; ANIMALS; BONE AND BONES; BONE RESORPTION; CALCIFICATION, PHYSIOLOGIC; DIPHOSPHONATES; ESTROGENS; FEMALE; INFUSIONS, INTRAVENOUS; RATS; RATS, INBRED F344;

EID: 35348820573     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.06.021     Document Type: Article

References (30)

1. Boivin G., Lips P., Ott S.M., Harper K.D., Sarkar S., Pinette K.V., et al. Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J Clin Endocrinol Metab 88 (2003) 4199-4205
2. Borah B., Dufresne T.E., Ritman E.L., Jorgensen S.M., Liu S., Chmielewski P.A., et al. Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: Sequential triple biopsy studies with micro-computed tomography. Bone 39 (2006) 345-352
3. Borah B., Ritman E.L., Dufresne T.E., Jorgensen S.M., Liu S., Sacha J., et al. The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnover. Bone 37 (2005) 1-9
4. Follet H., Boivin G., Rumelhart C., and Meunier P.J. The degree of mineralization is a determinant of bone strength: a study on human calcanei. Bone 34 (2004) 783-789
5. Liberman U.A., Weiss S.R., Broll J., Minne H.W., Quan H., Bell N.H., et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. N Engl J Med 333 (1995) 1437-1443
6. Harris S.T., Watts N.B., Genant H.K., McKeever C.D., Hangartner T., Keller M., et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. JAMA 282 (1999) 1344-1352
7. Riggs B.L., and Melton III L.J. Bone turnover matters: the raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone density. J Bone Miner Res 17 (2002) 11-14
8. Reid S.A., and Boyde A. Changes in the mineral density distribution in human bone with age: image analysis using backscattered electrons in the SEM. J Bone Miner Res 2 (1987) 13-22
9. Boivin G.Y., Chavassieux P.M., Santora A.C., Yates J., and Meunier P.J. Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone 27 (2000) 687-694
10. Boskey A.L., DiCarlo E., Paschalis E., West P., and Mendelsohn R. Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation. Osteoporos Int 16 (2005) 2031-2038
11. Roschger P., Rinnerthaler S., Yates J., Rodan G.A., Fratzl P., and Klaushofer K. Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29 (2001) 185-191
12. Russell R.G., and Rogers M.J. Bisphosphonates: from the laboratory to the clinic and back again. Bone 25 (1999) 97-106
13. Durchschlag E., Paschalis E.P., Zoehrer R., Roschger P., Fratzl P., Recker R., et al. Bone material properties in trabecular bone from human iliac crest biopsies after 3- and 5-year treatment with risedronate. J Bone Miner Res 21 (2006) 1581-1590
14. Lane N.E., Kumer J., Yao W., Breunig T., Wronski T., Modin G., et al. Basic fibroblast growth factor forms new trabeculae that physically connect with pre-existing trabeculae, and this new bone is maintained with an anti-resorptive agent and enhanced with an anabolic agent in an osteopenic rat model. Osteoporos Int 14 (2003) 374-382
15. Lane N.E., Yao W., Kinney J.H., Modin G., Balooch M., and Wronski T.J. Both hPTH(1-34) and bFGF increase trabecular bone mass in osteopenic rats but they have different effects on trabecular bone architecture. J Bone Miner Res 18 (2003) 2105-2115
16. Yao W., Hadi T., Jiang Y., Lotz J., Wronski T.J., and Lane N.E. Basic fibroblast growth factor improves trabecular bone connectivity and bone strength in the lumbar vertebral body of osteopenic rats. Osteoporos Int 16 (2005) 1939-1947
17. Parfitt A.M. Bone histomorphometry: standardization of nomenclature, symbols and units (summary of proposed system). Bone 9 (1988) 67-69
18. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2 (1987) 595-610
19. Yao W., Balooch G., Balooch M., Jiang Y., Nalla R.K., Kinney J., et al. Sequential treatment of ovariectomized mice with bFGF and risedronate restored trabecular bone microarchitecture and mineralization. Bone 39 (2006) 460-469
20. Kinney J.H., Haupt D.L., Balooch M., Ladd A.J., Ryaby J.T., and Lane N.E. Three-dimensional morphometry of the L6 vertebra in the ovariectomized rat model of osteoporosis: biomechanical implications. J Bone Miner Res 15 (2000) 1981-1991
21. Fratzl P., Schreiber S., and Klaushofer K. Bone mineralization as studied by small-angle X-ray scattering. Connect Tissue Res 34 (1996) 247-254
22. Fratzl P., Paris O., Klaushofer K., and Landis W.J. Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle X-ray scattering. J Clin Invest 97 (1996) 396-402
23. Balooch G., Marshall G.W., Marshall S.J., Warren O.L., Asif S.A., and Balooch M. Evaluation of a new modulus mapping technique to investigate microstructural features of human teeth. J Biomech 37 (2004) 1223-1232
24. Lane N.E., Yao W., Balooch M., Nalla R.K., Balooch G., Habelitz S., et al. Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res 21 (2006) 466-476
25. Wronski T.J., Cintron M., and Dann L.M. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Int 43 (1988) 179-183
26. Currey J.D. Effects of differences in mineralization on the mechanical properties of bone. Philos Trans R Soc Lond B Biol Sci 304 (1984) 509-518
27. Zoehrer R., Roschger P., Paschalis E.P., Hofstaetter J.G., Durchschlag E., Fratzl P., et al. Effects of 3- and 5-year treatment with risedronate on bone mineralization density distribution in triple biopsies of the iliac crest in postmenopausal women. J Bone Miner Res 21 (2006) 1106-1112
28. Hernandez C.J., and Keaveny T.M. A biomechanical perspective on bone quality. Bone 39 (2006) 1173-1181
29. Goldman H.M., Bromage T.G., Boyde A., Thomas C.D., and Clement J.G. Intrapopulation variability in mineralization density at the human femoral mid-shaft. J Anat 203 (2003) 243-255
30. Yerramshetty J.S., Lind C., and Akkus O. The compositional and physicochemical homogeneity of male femoral cortex increases after the sixth decade. Bone 39 (2006) 1236-1243