Basic fibroblast growth factor forms new trabeculae that physically connect with pre-existing trabeculae, and this new bone is maintained with an anti-resorptive agent and enhanced with an anabolic agent in an osteopenic rat model

Osteoporosis International

Volumn 14, Issue 5, 2003, Pages 374-382

  Lane, N E ^a   Kumer, J ^a   Yao, W ^a   Breunig, T ^b   Wronski, T ^c   Modin, G ^a   Kinney, J H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of Florida College of Veterinary Medicine   (United States)

Author keywords

bFGF; Bone formation; Osteoporosis

Indexed keywords

ANABOLIC AGENT; BASIC FIBROBLAST GROWTH FACTOR; CREATININE; DEOXYPYRIDINOLINE; ESTRADIOL; ESTROGEN; OSTEOCALCIN; PARATHYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE FRAGILITY; BONE MASS; BONE TURNOVER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTROGEN DEFICIENCY; FEMALE; NONHUMAN; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; TIBIA; TOMOGRAPHY; TRABECULAR BONE;

ANIMALS; BONE RESORPTION; DISEASE MODELS, ANIMAL; ESTRADIOL; FEMALE; FIBROBLAST GROWTH FACTOR 2; OSTEOGENESIS; OSTEOPOROSIS; OVARIECTOMY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TERIPARATIDE;

EID: 0041705932     PISSN: 0937941X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00198-003-1374-7     Document Type: Article

References (45)

1. Bouillon R, Burkhardt P, Christiansen C, Fleisch HA, Fujita T, Gennari C, Martin TJ, Mazzuoli G, Melton LJ, Ringe JD, et al. (1991) Consensus Development Conference: Prophylaxis and treatment of osteoporosis. Osteoporosis Int 1:114-117
2. Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ (1985) Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 7:178-208
3. Lindsay R, Hart DM, Clark DM (1984) The minimal effective dose of estrogen for prevention of postmenopausal bone loss. Obstet Gynecol 63:759-764
4. Chow J, Tobias H, Coston KW, Chambers TJ (1992) Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation. J Clin Invest 89:74-78
5. Lane NE, Haupt D, Kimmel DB, Modin G, Kinney JH (1999) Early estrogen replacement therapy reverses the rapid loss of trabecular bone volume and prevents further deterioration of connectivity in the rat. J Bone Miner Res 282:637-645
6. Black DB, Cummings SR, Karpt DB, Cauley JA, Thompson DE, Nevitt MC, Bauer DC, Genant HK, Haskett WJ, Marcus M, Ott SM, Torner JC, Quandt SA, Reiss TF, Ensrud KE (1996) Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet 348:1535-1541
7. Chesnut CH, Silverman S, Andriano K, Genant HK, Gimona A, Harris S, Kiel D, LeBoff M, Maricic M, Miller P, Moniz C, Peacock M, Richardson P, Watts N, Baylink D for PROOF Study Investigators (2000) A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: 'The prevent recurrence of osteoporotic fracture studies'. Amer J Med 109:267-276
8. Delmas PD, Bjarnason NH, Mitlak BH, et al. (1996) Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 337:1641-1647
9. Chavassieux PM, Arlot ME, Reda C, Wei L, Yates J, Menuier PJ (1997) Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis. J Clin Invest 100(6):1475-1480
10. Lane NE, Thompson JM, Strewler GJ, Kinney JH (1995) Intermittent treatment with human parathyroid hormone (hPTH[1-34]) increased trabecular bone volume but not connectivity in osteopenic rats. J Bone Miner Res 10 (10):1470-1477
11. Mosekilde L, Danielson CC, Gasser J (1994) The effect on vertebral bone mass and strength of long-term treatment with anti-resorptive agents (estrogen and calcitonin), human parathyroid hormone-(hPTH[1-38]), and combination therapy, assessed in aged ovariectomized rats. Endocrinology 134(5):2126-2134
12. Wronski TJ, Yen C-F, Qi H, Dann LM (1993) Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats. Endocrinology 132:823-831
13. Lindsay R, Nieves J, Formica C, et al. (1997) Randomized controlled study of the effect of PTH on vertebral bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet 350:550-555
14. Recker RR (1993) Architecture and vertebral fracture. Calcif Tiss Int 53 (Suppl. 1):139-142
15. Liang H, Pun S, Wronski TJ (1999) Bone anabolic effects of basic fibroblast growth factor in ovariectomized rat. Endocrinology 140 (12):5780-5788
16. Pun S, Floria CL, Wronski TJ (2000) Anabolic effects of basic fibroblast growth factor in the tibial diaphysis of ovariectomized rats. Bone 27(2):197-202
17. Canalis E, Centrella M, McCarthy T (1988) Effects of fibroblast growth factor on bone formation in vitro. J Clin Invest 81:1572-1577
18. Dunstan CR, Boyce R, Boyce BF, Garrett IR, Izbicka E, Burgess WH, Mundy GR (1999) Systemic administration of acidic fibroblast growth factor (FGF-1) prevents bone loss and increases new bone formation in ovariectomized rats. J Bone Miner Res 14:953-959
19. Noff D, Pitaru S, Savion N (1989) Basic fibroblast growth factor enhances the capacity of bone marrow cells to form bone-like nodules in vitro. FEBS Letter 250:619-621
20. Rodan SB, Wesolowski G, Thomas KA, Yoon K, Rodan GA (1989) Effects of acidic and basic fibroblast growth factors on osteoblastic cells. Connect Tissue Res 20:283-288
21. Pitaru S, Kotev-Emeth S, Noff D, Kaffuler S, Savion N (1988) Effect of basic fibroblast growth factor on the growth and differentiation of adult stromal bone marrow cells: enhanced development of mineralized bone-like cells in culture. Bone 23:111-117
22. Hanada K, Dennis JE, Caplan AI (1997) Stimulatory effects of basic fibroblast growth factor and bone morphogenic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. J Bone Miner Res 12:1606-1614
23. Waynforth HB (1980) Experimental and surgical techniques in the rat. Academic Press, New York
24. Kalu KN (1991) The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175-192
25. Kinney JH, Lane NE, Haupt D (1995) Three dimensional in vivo microscopy of sequential changes in trabecular architecture following estrogen depletion in female rats. J Bone Miner Res 10:264-270
26. Lane NE, Thompson JM, Haupt D, Kimmel DB, Modin G, Kinney JH (1998) Acute changes in trabecular bone connectivity and osteoclast activity in the ovariectomized rat in vivo. J Bone Min Res 13(2):229-236
27. Kinney JH, Haupt DL, Balooch M, Ladd AJC, Ryaby JT, Lane NE (2000) Three-dimensional morphometry of the L6 vertebrae in the ovariectomized rat model in osteoporosis: biomechanical implications. J Bone Min Res 15(10):1981-1991
28. Nuzzo S, Peyrin F, Cloetens P, Baruchel J, Bolvin G (2002) Quantification of the degree of mineralization of bone in three dimensions using synchrotron radiation microtomography. Medical Physics 29:2672-2681
29. Parfitt AM (1983) The physiologic and clinical significance of bone histomorphometric data. In: Recker RR (ed) Bone histomorphometry: techniques and interpretation. CRC Press, Boca Raton, FL, pp 143-224
30. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, et al. (1987) Bone histomorphometry: standardization of nomenclature, symbols, and units. J Bone Miner Res 2:595-610
31. Odgaard A, Gundersen HJG (1993) Quantification of connectivity in cancellous bone with special emphasis on 3-D reconstructions. Bone 14:173-182
32. Seyedin SM, Kung VT, Daniloff YN, Hesley RP, Gomez B, Nielsen LA, Rosen HN, Zuk RF (1993) Immunoassay for urinary pyridinoline: the new marker of bone resorption. J Bone Miner Res 8:635-641
33. Delmas PJ, Schlemmer A, Gineyts E, Riis B, Christiansen C (1991) Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with osteoporosis. J Bone Miner Res 6:639-644
34. Sokal R, Rohlf FJ (1969) Biometry, Freeman, San Francisco, CA
35. Mundy GR, Boyce B, Hughes D, Wright K, Bonewald L, Dallas S, Harris S, Ghosh-Choudhury N, Chen D, Dunstand C, Izbicka E, Yoneda T (1995) The effects of cytokines and growth factors on osteoblastic cells. Bone 17:71S-75S
36. Hurley MM, Abreu C, Harrison JR, Lichtler AC, Raisz LG, Kream BE (1993) Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-E1 cells. J Biol Chem 268:5588-5593
37. Globus RK, Plouet J, Gospodarowicz D (1989) Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix. Endocrinology 124:1539-1547
38. Leboy PS, Beresford JN, Devlin C, Owen ME (1991) Dexamethasone induction of osteoblast mRNA in rat marrow stromal cell cultures. J Cell Physiol 146:370-378
39. Scutt A, Bertram P (1999) Basic fibroblast growth factor in the presence of dexamethasone stimulates colony formation, expansion, and osteoblastic differentiation by rat bone marrow stromal cells. Calcif Tissue Int 64:69-77
40. Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME (1992) Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 102:341-351
41. Hurley MM, Lee SK, Riasz LG, Benecker P, Lorenzo J (1998) Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures. Bone 22(4):309-316
42. Noda M, Camilliere JJ (1989) In vivo stimulation of bone formation by transforming growth factor beta. Endocrinology 124:2991-2994
43. Nakamura K, Kurokawa T, Aoyama I, Hanada K, Tamura M, Kawaguchi H (1998) Stimulation of bone formation by intraosseous injection of basic fibroblast growth factor in ovariectomized rats. Int Ortho 22:49-54
44. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL (2000) The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 15(1):2-12
45. Wronski TJ, Ratkus AM, Thomsen JS, Vulcan TQ, Mosekilde L (2001) Sequential treatment with basic fibroblast growth factor and parathyroid hormone restores lost cancellous bone mass and strength in the proximal tibia of aged ovariectomized rats. J Bone Miner Res 16(8):1399-1407