Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering

Journal of Clinical Investigation

Volumn 97, Issue 2, 1996, Pages 396-402

  Fratzl, P ^a,b   Paris, O ^b   Klaushofer, K ^a   Landis, W J ^c  

^a HANUSCH HOSPITAL   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

bone biomechanics; bone mineral; collagen; osteogenesis imperfecta; x ray scattering

Indexed keywords

COLLAGEN TYPE 1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE MINERAL; BONE MINERALIZATION; BONE STRENGTH; CONTROLLED STUDY; CORTICAL BONE; ELECTRON MICROSCOPY; FEMUR; HOMOZYGOTE; MOUSE MUTANT; NONHUMAN; OSTEOGENESIS IMPERFECTA; PRIORITY JOURNAL; RADIATION SCATTERING; TIBIA;

EID: 0030033534     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118428     Document Type: Article

References (23)

1. Kuivaniemi, H., G Tromp, and D. J. Prockop. 1991. Mutations in collagen genes: causes of rare and some common diseases in humans. FASEB J. 5: 2052-2060.
2. Byers, P. H., G. A. Wallis, and M. C. Willing. 1991. Osteogenesis imperfecta: translation of mutation to phenotype. J Med. Genet. 28:433-442.
3. Cole, W. G. 1994. Osteogenesis imperfecta as a consequence of naturally occurring and induced mutations of type I collagen. Bone Miner. Res. 8:167-204.
4. Traub, W.,T. Arad.U Vetter, and S. Weiner 1994. Ultrastructural studies of bone from patients with Osteogenesis imperfecta Matrix. 14:337-345
5. Vetter, U , M A. Weis, M. Mörike, E. D. Eanes, and D. R. Eyre. 1993. Collagen crosslinks and mineral crystallinity of patients with Osteogenesis imperfecta J Bone Miner. Res. 8:133-137.
6. Cassella, J. P., and S. Y. Ali 1992. Abnormal collagen and mineral formation in Osteogenesis imperfecta. Bone Miner. 17:123-128.
7. Stoss, H., and P. Freisinger. 1993. Collagen fibrils of osteoid in osteogenesis imperfecta: morphometrical analysis of the fibril diameter. Am. J. Med. Gen. 45.257.
8. Chipman, S. D., H. O. Sweet, D. J. McBride. Jr, M. T. Davisson, S. C. Marks, Jr., A. R. Shuldmer, R. J. Wenstrup, D. W. Rowe, and J. R. Shapiro. 1993. Defective proα2(I) collagen synthesis in a new recessive mutation of mice: A model of human Osteogenesis imperfecta Proc. Natl Acad Sci. USA. 90:1701-1705.
9. Deleted in proof.
10. Landis, W. J. 1995. Tomographic imaging of collagen-mineral interaction: Implications for Osteogenesis imperfecta. Connect. Tissue Res. In press.
11. Landis, W. J. 1995. The strength of calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix. Bone 16:533-544.
12. Fratzl, P., N. Fratzl-Zelman, K. Klaushofer, G. Vogl, and K. Koller. 1991. Nucleation and growth of mineral crystals in bone studied by SAXS. Calcif. Tissue Int. 48:407-413.
13. Fratzl. P., M. Groschner, Cr. Vogl, H. Plenk, J. Eschberger, N. Fratzl-Zelman, K Koller, and K. Klaushofer. 1992. Mineral crystals in calcified tissues: a comparative study by small-angle x-ray scattering. J. Bone Miner. Res. 7: 329-334.
14. Fratzl, P., P. Roschger. J Eschberger, B Abendroth, and K. Klaushofer. 1994. Abnormal bone mineralization after fluoride treatment in osteoporosis: a small-angle x-ray scattering study. J. Bone Miner. Res. 9:1541-1549.
15. Fratzl, P. 1994. Statistical model for the habit and arrangement of mineral crystals in the collagen of bone J. Stat. Phys 77:125-143.
16. Wagner, H. D., and S. Weiner. 1992. On the relationship between the microstructure of bone and its mechanical stiffness. J. Biomech. 25:1311-1320.
17. Landis, W. J, M. C. Paine, and M. J. Glimcher. 1977. Electron microscopic observations of bone tissue prepared anhydrously in organic solvents. J Ultrasiruct Res 59:1-30.
18. Perret, R., and W. Ruland. 1969 Single and multiple x-ray small-angle scattering of carbon fibres. J. Appl. Cryst. 2:209-218.
19. Matsushima, N., M. Akiyama. and Y. Terayama. 1982. Quantitative analysis of the orientation of mineral in bone from small-angle x-ray scattering patterns. Jap. J. Appl. Phys. 21:186-189.
20. Landis, W. J., M. J. Song, A. Leith, L. McEwen, and B. McEwen. 1993 Mineral and organic matrix interaction in normally calcifying tendon visualized in three dimensions by high-voltage electron microscopic tomography and graphic image reconstruction. J. Struct. Biol. 110:39-54.
21. Vetter, U., E. D. Eanes, J. B. Kopp, J. D. Termine, and P. Gehron Robey. 1991. Changes in apatite crystal size in bones of patients with osteogenesis imperfecta. Calcif. Tissue Int. 49:248-250.
22. Dunn, M. G., D. J. McBride, and J. R. Shapiro. 1995. Absence of the collagen α2(I) chain diminishes the mechanical properties of bone. Trans. Orthop. Res. Soc. 20:153.
23. Hulmes, D. J. S., T. J. Wess. D. J. Prockop, and P. Fratzl. 1995. Radial packing, order and disorder in collagen fibrils. Biophys. J. 68:1661-1670.