Basic fibroblast growth factor improves trabecular bone connectivity and bone strength in the lumbar vertebral body of osteopenic rats

Osteoporosis International

Volumn 16, Issue 12, 2005, Pages 1939-1947

  Yao, Wei ^a,b   Hadi, Tamer ^a,b   Jiang, Yebin ^a   Lotz, Jeff ^a   Wronski, Thomas J ^c   Lane, Nancy E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Center for Aging   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

bFGF; Biomechanical properties; Bone structure; Lumber vertebrae; Ovariectomy; Rat

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; PARATHYROID HORMONE[1-34];

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE STRENGTH; BONE TURNOVER; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; FORCE; KRUSKAL WALLIS TEST; MORPHOMETRICS; NONHUMAN; OSTEOPENIA; OVARIECTOMY; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TRABECULAR BONE; VERTEBRA BODY;

ANIMALS; BIOMECHANICS; BONE DISEASES, METABOLIC; ELASTICITY; FEMALE; FIBROBLAST GROWTH FACTOR 2; INJECTIONS, SUBCUTANEOUS; LUMBAR VERTEBRAE; OSTEOCLASTS; OVARIECTOMY; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; TOMOGRAPHY, X-RAY COMPUTED;

EID: 29044446044     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-005-1969-2     Document Type: Article

References (41)

1. Lane NE, Haupt D, Kinney JH (1997) Estrogen replacement therapy restores trabecular bone volume by altering microarchitecture in the ovariectomized rat. Transactions of the Orthopeadic Research Society, S211
2. Heaney RP (2003) Remodeling and skeletal fragility. Osteoporos Int 14 [Suppl 5]:12-15
3. Chavassieux PM, Arlot ME, Reda C, Wei L, Yates J, Menuier PJ (1997) Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis. J Clin Invest 100:1475-1480
4. Borah B, Dufresne TE, Chmielewski PA, Gross GJ, Prenger MC, Phipps RJ (2002) Risedronate preserves trabecular architecture and increases bone strength in the vertebrae of ovariectomized minipigs measured by 3-dimensional microcomputered tomorgraph. J Bone Miner Res 17:1139-1147
5. Wronski TJ, Cintron M, Doherty AL, Dann LM (1988) Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123:681-686
6. Lane NE, Thompson JM, Strewler GJ, Kinney JH (1995) Intermittent treatment with human parathyroid hormone (hPTH[1-34]) increased trabecular bone volume but not connectivity in osteopenic rats. J Bone Miner Res 10:1470-1477
7. Wronski TJ, Yen CF, Qi H, Dann LM (1993) Parathyroid hormone is more effective than estrogen for restoration of lost bone mass in ovariectomized rats. Endocrinology 132:823-831
8. Dempster DW, Cosman F, Kurland ES, Zhou H, Nieves J, Woelfert L, Shane E, Placetic K, Muller R, Bilizekian J, Lindsay R (2001) Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis. A paired biopsy study. J Bone Miner Res 16:1846-1853
9. Paschalis EP, Burr DB, Mendelsohn R, Hock JM, Boskey AL (2003) Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH (1-34) for 18 months. J Bone Miner Res 18:769-775
10. Lane NE, Sanchez S, Modin G, Genant HK, Pierini E, Arnaud CD (1998) Parathyroid hormone treatment can reverse steroid osteoporosis: results of a randomized clinical trial. J Clin Invest 102:1627-1633
11. Liang H, Pun S, Wronski TJ (1999) Bone anabolic effects of basic fibroblast growth factor in ovariectomized rats. Endocrinology 140:5780-5788
12. Pun S, Florio CL, Wronski TJ (2000) Anabolic effects of basic fibroblast growth factor in the tibial diaphysis of ovariectomized rats. Bone 27:197-202
13. Pun S, Dearden RL, Ratkus AM, Liang H, Wronski TJ (2001) Decreased bone anabolic effects of basic fibroblast growth factor at fatty marrow sites in ovariectomized rats. Bone 28:220-226
14. Wronski TJ, Ratkus AM, Thomsen JS, Vulcan Q, Mosekilde L (2001) Sequential treatment with basic fibroblast growth factor and parathyroid hormone restores lost cancellous bone mass and strength in the proximal tibia of aged ovariectomized rats. J Bone Miner Res 16:1399-1407
15. Iwaniec UT, Mosekilde L, Mitova-Caneva NG, Thomsen JS, Wronski TJ (2002) Sequential treatment with basic fibroblast growth factor and PTH is more efficacious than treatment with PTH alone for increasing vertebral bone mass and strength in osteopenic ovariectomized rats. Endocrinology 143:2515-2526
16. Lane, NE, Yao W, Kinney JH, Modin G, Balooch M, Wronski T (2003) Both hPTH (1-34) and bFGF increase trabecular bone mass in osteopenic rats, however they have different effects on trabecular bone architecture. J Bone Miner Res 18:2105-2115
17. Jiang Y, Zhao J, Mitlak BH, Wang O, Genant HK, Eriksen EF (2003) Recombinant human parathyroid hormone (1-34) (teriparatide) improves both cortical and cancellous bone structure. J Bone Miner Res 18:1932-194
18. Laib A, Kumer JL, Majumdar S, Lane N (2001) The temporal changes in trabecular architecture in ovariectomized rats assessed by microCT. Osteoporos Int 12:936-941
19. Lane NE, Kumer JL, Majumdar S, Khan M, Lotz J, Steven RE, Klein R, Phelps KV (2002) The effects of synthetic conjugated estrogens, A (Cenestin) on trabecular bone structure and strength in the ovariectomized rat model. Osteoporosis Int 13:816-823
20. Hildebrand T, Rüegsegger P (1997) A new method for the model independent assessment of thickness in three-dimensional images. J Microsc 85:67-75
21. Maeda H, Kimmel DB, Raab D, Lane NE (1993) The musculoskeletal response to immobilization and recovery. Bone 14:153-159
22. Parfitt AM, Drezner MK, Glorieux FH, Janis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nomenclature, symbols and units. Report of the ASBMR Histomorphometry Committee. J Bone Miner Res 2:595-610
23. Parfitt AM, Matthews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS (1983) Relationships between surface, area, and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 72:1396-1409
24. Linde F, Gothgen DB, Hvid I, Pongsoipetch B (1988) Mechanical properties of trabecular bone by nondestructive compression testing approach. Eng Med 17:23-29
25. Lotz JC, Kroeber MW, Heilmann K, Pericherla K, Kimmel D, Kinney JH, Lane NE (2000) Tibial plateau fracture as a measure of early estrogen-dependent bone fragility in rats. J Orthopaed Res 18:326-332
26. Lane NE, Yao W, Kumer J, Breuning T, Wronski T, Modin G, Kinney JH (2002) Basic fibroblast growth factor partially restores trabecular bone architecture in osteopenic ovariectomized rats. Osteoporosis Int 14:374-382
27. Faulkner KG, McClung M, Cumming SR (1994) Automated evaluation of hip axis length for predicting hip fracture. J Bone Miner Res 9:1065-1070
28. Duan Y, Parfitt M, Seeman E (1999) Vertebral bone mass, size and volumetric density in women with spinal fracture. J Bone Miner Res 14:1796-1802
29. Ito M, Nishida A, Koga A, Ikeda S, Shiraishi A, Uetani M, Hayashi K, Nakamura T (2002) Contribution of trabecular and cortical components to the mechanical properties of bone and their regulating parameters. Bone 31:351-358
30. Van der Meulen MCH, Jepsen KJ, Mikic B (2001) Understanding bone strength: size isn't everything. Bone 29:101-104
31. Bell GH, Dunbar O, Beck JR, Gibb A (1967) Variations in strength of vertebrae with age and their relation to osteoporosis. Calcif Tissue Int 1:75-86
32. Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS (1983) Relationship between surface, volume, and thickness of iliac trabecular bone in aging and osteoporosis. J Clin Invest 72:277-282
33. Lane NE, Haupt D, Modin G, Kinney JH (1998) The acute changes in trabecular bone connectivity and osteoclast activity in a rat model of estrogen deficiency. J Bone Miner Res 13:229-236
34. Qi H, Li M, Wronski TJ (1995) A comparison of the anabolic effects of parathyroid hormone at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats. J Bone Miner Res 10:948-952
35. Recker RR (1993) Architecture and vertebral fracture. Calcif Tissue Inc 53:s139-s142
36. Ito M, Nishida A, Koga A, Ikeda S, Shiraishi A, Uetani M, Hayashi K, Nakamura T (2002) Contribution of trabecular and cortical components to the mechanical properties of bone and their regulating parameters. Bone 31:351-358
37. Pothuaud L, Rietbergen BV, Mosekilde L, Beuf O, Levitz P, Benhamou CL, Majumdar S (2002) Combination of topological parameters and bone volume fraction better predicts the mechanical properties of trabecular bone. Bone 35:1091-1099
38. Ulrich D, Rietbergen BV, Laib A, Rüegsegger P (1999) The ability of three-dimensional structure indices to reflect mechanical aspects of trabecular bone. Bone 25:55-60
39. Wachter NJ, Augat P, Mentzel M, Sarkar MR, Krischak GD, Kinzi L, Claes LE (2001) Predictive value of bone mineral density and morphology determined by peripheral quantitative computed tomography for cancellous bone strength of the proximal femur. Bone 28:133-139
40. Thomsen JS, Ebbesen EN, Mosekilde L (2002) Predicting human veterbral bone strength by vertebral static histomorphometry. Bone 30:502-508
41. Ikeda S, Tsurukami H, Ito M, Sakai A, Sakata T, Nishida S, Takeda S (2001) Effects of trabecular bone turnover contour on ultimate strength of lumbar vertebra after bilateral ovariectomy in rats. Bone 28:625-633